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Biomedical subjects

J Töwe

Publications and source records attributed to J Töwe.

At least 37 records · Page 2Linked to original sources
PubMed1977

[Occupational and extra-occupational stresses during pregnancy subjectively assessed by the gravida and their significance in relation to other perinatal risks for the newborn infant].

6780 mothers postpartaly were asked how they assess their occupational employment. We made following groups: the work is physically very strain, middle strain or not strain, the work is mentally very exert, middle exert or not exert. We selected 2/3 or all cases to have high risk in pregnancy or neonatal period. We found statistical coherences between the subjective judgement and the social status. The correlations between the subjective judgement of the occupational employment and the risk factors of the perinatal period were loose. The correlations between the perinatal risk factors and the objective social dates (trade, number of children, age of the mother etc.) are better than between perinatal dates and subjective assessment of their occupational employment by the mother.

Adult↗
PubMed1977

[Assessment of liver function using indocyanine green (Ujoviridin) during normal pregnancy, during labor and in puerperium].

Indocyaningreen (ICG) was given for the characterize of the excretion function of the liver during the course of normal pregnancy, sub partu and post partum. Studies were performed in 168 primi- and multigravidas with normal medical and obstetric histories (mean age of 23,5 years). 0,5 mg ICG/kg body mass were injected intravenously as a bolus. 18 healthy nonpregnant women served as controls (mean age of 24,2 years). In the I. and II. trimester of pregnancy the elimination of ICG was not decreased in comparison to the controls (3,64 +/- 0,86). The increased retention of ICG in the 40th week of pregnancy (4,67 +/- 0,41) and during labor (7,02 +/- 2,32) are caused through the physiological alterations of pregnancy. No placental transfer of the dye could be detected by simultaneous measurement of ICG in the maternal and fetal cord blood. During the post partum period the elimination of ICG will be normal. ICG is recommend instead of Bromsulfaleine (BSP) for the estimation of excretion function of the liver during pregnancy and childbed.

Adolescent↗
PubMed1977

[Evaluation of multidimensional screenings within prematurity-dysmaturity-preventive programs].

Evaluation of multidimensional screenings within the prematurity-dysmaturity-preventive-programmes. We estimated the PDP-programmes recommended in literature. The result is discussed together with the analysis of our 6000 investigated cases. We found, that, the published scores, using many factors and basing on multidimensional regression or discriminant analysis, give not a satisfactory result in predicting birth of a newborn with low weight. If you wish predict right 90% of all low birth weight infants, your risk group contains about 50% of all pregnant women. If you wish to have only a trifling risk group of 10% of all pregnant women, you can predict right only about 50% of all infants with low birth weight. We recommend for practice to go an other way. We find it is better for prophylaxis and therapy of the threatened premature labour to diagnose and treat special risks as placenta praevia, multiple pregnancies, hemorrhage during pregnancy, smoking and anamnestic previous prematurity. The summarizing of risk points is to our opinion of minor importance. Only pregnant women with risks, which need expansive apparatus and specialists, should be sended for a perinatal center (Rh-incompatibility, hydramnious, suspicious malformation, severe intern diseases). Especially the diagnosis and therapy of genetic defects must be carried out in a center. About the possibility with genetic diagnostic to diminute the birth of impaired children of low weight is given a particular explanation.

Evaluation Studies as Topic↗
PubMed1976

[Antibody binding bacteria in the urine in chronic pyelonephritis].

Using the direct immunofluorescence technique antibody-coated bacteria were demonstrated in urine samples from 49 of 57 patients with the clinical diagnosis of chronic pyelonephritis, but were not observed in urines from 11 patients with cystitis. A correlation rate was found between the presence of antibody-coated bacteria in the urine seidment and elevated serum antibody titers in the pyelonephritis group as determined by the indirect immunofluorescence technique. Patients with elevated serum antibody titers without antibody-coated bacteria in the urine, and vice versa, were also found. Patients with cystitis did not have elevated serum antibody titers against the homologous strain isolated from the urine. The clinical diagnosis of chronic pyelonephritis could be confirmed in 86.5% of patients taking into account the presence of antibody-coated bacteria and/or elevated serum antibody titers.

Adult↗
PubMed1976

On the influence of prostaglandin F2alpha-induced labor at term on the metabolism and coagulation of mother and fetus.

11 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGF2alpha. The average infusion time was 3 hours 55 minutes, and the average total dose of PGF2alpha amounted to 2.0 mg. Parameters of acid-base changes, carbohydrate and energic state changes, gas metabolism, and changes in coagulation and fibrinolysis in mother and in fetus were analyzed during labor and after birth. Labor activity and fetal cardiac action were monitored cardiotocographically. Checked against 50 uncomplicated spontaneous deliveries, we found no disadvantageous changes in the parameters investigated.

Acid-Base Equilibrium↗
PubMed1976

[Use of discrimination analysis in perinatology].

From 50 normal births blood of mother and child was examined simultaneously at three different times, meant for determination of 13 biochemical parameters. Evaluation of the measured values was done by the multivariate method of discriminance analysis. Basing on the observed data problems of discriminance analysis are dealt with in an introductive way. The perinatal example is used to demonstrate how in the case of a complex problem connections may be better visible by this method, though detailed informations are lost.

Adenosine Triphosphate↗
PubMed1976

[Liver function tests under the influence of sequential treatment using ethinyl estradiol-norethisterone acetate and ethinyl estradiol-chlormadinone acetate].

30 young healthy women were investigated during the first therapy cycle with ethinyl-estradiol-norethisterone acetate and ethinyl-estradiol-chlormadinone acetate as a sequential regime. The following laboratory data were achieved by each of the investigated group of young women: serum aminotransferase (GOT and GPT), serum alkaline phosphatase and alpha-amylase-activity in serum, serum proteins, serum cholesterol, serum bilirubin, serum ZST, serum TTT and the indocyaningreen-clearance of the liver. The serum protein pattern was determined by the paper electrophoretic method. A significant decrease of the aminotransferase GPT was viable during the sequential therapy with ethinyl-estradiol and norethisterone acetate. This viable decrease of the GPT was induced through the application of norethisterone acetate to estrogen. The alkaline phosphatase was significant lightly lower and the beta-globuline lightly elevated at the end of the therapy cycle. The sequential therapy with ethinyl-estradiol and chlormadinone acetate induced only a significant increase of the ZST in serum.

Adolescent↗
PubMed1976

[Use of filter paper to identify antibodies against Myxovirus influenzae].

A total of 165 sera and 142 eluates from filtration papers impreggnated with whole blood were examined in reaction of complement fixation against A/Hong Kong 1/68 (H3N2) and B/Johannesburg 3/56 virus. To perform HIT 152 sera and 155 eluates were used. The results obtained were elaborated statistically. The method of filtration papers does not seem to be suitable for HIT, whereas the CFT was in several cases practicable.

Antibodies, Viral↗
PubMed1976

[Behavior of serum alkaline during pregnancy. II. Pathological pregnancy].

832 estimations of heat stable alkaline phosphatase (HSAP) and of heat alkaline phosphatase (HLAP) were carried out simultaneously in late pregnant women at 25th to the 42nd weeks of pregnancy. 147 of them delivered children with normal birth-weight. All these women suffered from pre-eclampsia, hypertension or any kind of superimposed pre-eclampsia. 110 other pregnant women with or without symptoms of pre-eclampsia gave birth to small for dates babies. In addition, the values of these patients were compared with 372 estimations of the same enzymes carried out in 120 patients with normal pregnancy and outcome of normal weighted children. The site of the values of every group showed no typical correlation to the course and outcome of their pregnancy. Regarding four special criterions it was possible to give a good prediction by serial determinations for the weight of the newborn in 80 per cent of the cases. A correlation between the urinary excretion of total oestrogens as well as HLAP and the values of HSAP was to be found only in some groups of patients.

Alkaline Phosphatase↗
PubMed1976

[Effect of social factors on the relations between working mother and premature birth rate].

Basing on the results of a study of 6780 women we found already at the beginning of the 1970 years in the GDR a premature birth rate for occupied women not more unfavourable than for house-wives; the total rate by then was 5,9%. The present paper deals with the influence of certain social factors--e. g. educational and social status, personal status, number of children within a family - on the frequency of premature births for occupied women and house-wives.

Adult↗
PubMed1975

[Indirect immunofluorescence in the serological diagnosis of chronic pyelonephritis (comparison with indirect haemagglutination and the Widal reaction (author's transl)].

Using indirect immunofluorescence, o-antibodies against the homologous causative organism were determined in 119 adults with chronic pyelonephritis, during a one to two-and-a-half year period. Humoral antibodies were determined in the same group of patients with the Widal reaction and indirect haemagglutination. The results were compared with those in a group of adults without renal disease, using the same serological reactions. In adults with chronic pyelonephritis the antibody titre (by immunofluorescence) was above normal limits (as obtained in the healthy group) in 63.1%. The corresponding results for the Widal reaction and indirect haemagglutination reaction were 16.5% and 12, respectively. Indirect immunofluorescence is thus clearly better than the other two serological methods in the diagnosis of chronic pyelonephritis.

Antibodies↗
PubMed1975

[Liver function tests after a 6-month deposiston therapy].

18 women were treated with Deposition (4th, 11th and 18th cycle day each 1 mg 17alpha-Ethynyl-3isopropylsulfonyloxy-Estradiol, 25th cycle day 10 mg norethisterone acetate). When these medicines were taken the activities of aminotransferases, alkaline phosphatase and alpha-amylase, the contents cholesterol, total bilirubin and proteins of the serum and the paperelectric solution, TTT and indocyanine green half worth time. A little significant decrease of the activity of alaninamino-transferase (GPT) was to be stated. Whereas at the end of the 6th cycle the TTT as well as the contents of total proteins and albumin, showed a little significant decrease and the contents of alpha2-globulin, beta-globulin as well as cholesterol were statistically shown to grow. The indocyanine green elimation was longer at the end of the 6th cycle without any pathological worth from clinical point of view being proved.

Adult↗
PubMed1975

[Behavior of alkaline phosphatase in serum during pregnancy. I. Normal pregnancy].

On 120 patients, during normal pregnancy, from the 17th to the 42nd week of pregnancy, 372 heat labile alkaline phosphatase estimations were carried out by means of the 4-nitrophenol method. In addition to that, after incubation of sera at 65 degrees C for 30 minutes, the activity of the heat stable placental isoenzyme was checked. With progressing pregnancy, the heat stable fraction rises significantly and the heat labile fraction of total alkaline phosphatase increases slightly. There is a correlation between the readings of the two fractions. In 169 cases, the total urinary oestrogen output correlates also with the heat stable alkaline phosphatase.

Alkaline Phosphatase↗
PubMed1975

[Influence of labor induced by prostaglandins on the metabolism and blood coagulation system of the mother and child during labor].

22 pregnancies at term were terminated by dilatation of the uterine cervix, low amniotomy, and by intravenous administration of PGF2alpha or PGE2. The average infusion time was 4 hours 10 minutes, and the average total dose of PGF2alpha amounted to 2,0 mg and of PGE2 0,2 mg. Parameters of acid-base changes, carbohydrate and energic state changes, gas metabolism, and changes in coagulation and fibrinolysis in mother and in fetus were analyzed during labor and after birth. Labor activity and fetal cardiac action were monitored cardiotocographically. Checked against 50, and for the coagulation 12 uncomplicated spontaneous deliveries, we have found no disadvantageous changes in the parameters investigated.

Acid-Base Equilibrium↗