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Biomedical subjects

J Teuber

Publications and source records attributed to J Teuber.

At least 37 records · Page 2Linked to original sources
PubMed1987

Transplantation of human endocrine tissues to nude mice: a suitable in vivo model for the study of pathomechanisms involved in autoimmune thyroid diseases.

After transplantation of human tissue to nu/nu mice the human lymphocytes disappear. In this context, interestingly, the DR-expression is not detectable anymore after transplantation of the tissues from patients with autoimmune thyrotoxicosis and cancer. Neopterin release was only demonstrable when T-lymphocytes from patients with autoimmune thyrotoxicosis or PHA-stimulated lymphocytes were added, independently of the presence of DR-expression in the used culture tissues. These results seem to exclude a functional role of DR-expression as a trigger mechanism of autoimmunity. It is supposed that DR-priming on epithelial cells is mediated by kinine production of activated T-lymphocytes or macrophages.

Animals↗
PubMed1986

Response of total and 'free' thyroid hormones and diiodotyrosine to bovine TSH in subclinical hypothyroidism.

Thirty-three patients with Addison's disease were studied. Twenty-two had idiopathic Addison's disease; within this group, 14 patients had clinical or subclinical hypothyroidism, and 16 had increased titres of thyroid autoantibodies. Five patients had tuberculous, and eight had unclassifiable Addison's disease; only one patient in the latter group had evidence of thyroid autoimmunity. A stimulation test with 15 mU bTSH/kg was performed in three patients with Schmidt's syndrome (coexisting Addison's disease and manifest primary hypothyroidism), 15 patients with either subclinical hypothyroidism or increased titres of thyroid autoantibodies, 10 patients without thyroid involvement, and 10 normal controls. There was no detectable increase of 'free' and total thyroid hormones in Schmidt's syndrome. The mean increases after 3-4 h of T4, fT4, T3 and fT3 were 22, 35, 63 and 66%, respectively, in patients without thyroid involvement, and 13, 24, 46 and 45% in patients with subclinical hypothyroidism. 'Free' but not total thyroid hormones rose significantly (P less than 0.01) higher in patients without signs of thyroid involvement than in patients with subclinical hypothyroidism and/or thyroid autoantibodies. Thyroid hormone response to bTSH in Addison's disease with apparently healthy thyroid glands was not different from normal controls. Serum diiodotyrosine rose in all groups except in hypothyroidism; hypothyroid patients had, however, basal levels well within the normal range. Thus, thyroid hormone synthesis appears to be blocked at a point distal to diiodotyrosine formation in this particular situation. These results support the assumption that TSH elevation in idiopathic Addison's disease is due to coexisting thyroid autoimmunity and that it reflects incipient thyroid failure.(ABSTRACT TRUNCATED AT 250 WORDS)

Addison Disease↗
PubMed1983

[Immunohistologic determination of a tumor marker (CEA) in diseases of the gastrointestinal tract].

CEA levels in serum are not reliable markers of tumors. In this paper a method for determination of this antigen for tissue sections is given. Histology, immunohistology and serum levels of CEA were compared. Tissue sections were obtained by surgical and endoscopic techniques. In several cases there was a discrepancy between serological and morphological results. Based on recent investigations elevated CEA levels might be only useful in reflecting a relapse of carcinoma of the colon. Immunohistological determinations were done by IFT and PAP-method. The results of both assay systems were comparable. CEA could be also detected in benign neoplasiogenic tissue, i.e. in tubular type of adenomatose polyps and in ulcerative colitis. Both diseases are known to become malignant at an high degree. By contrast no CEA could be detected in hyperplasiogenic polyps. Detection of CEA in malignant tissue might be useful for final classification of tumors. Occurrence of CEA in non malignant tissue should give rise to control in short regular intervals. Prospective studies might show the reliability of the CEA-bearing cells of non malignant tissue.

Adolescent↗
PubMed1983

[Introduction to the etiology and pathogenesis of autoimmune forms of thyroid diseases].

Graves' disease and Hashimoto's thyroiditis are representing typical endocrine disorders caused by dysfunction of the immune system. In this context the occurrence of thyroid cell-specific autoantibodies is regarded as a characteristic indicator of autoimmunity. HLA-linked, disturbed lymphocytic interactions are discussed as the etiologic factors of these diseases because of their inability to discrime between "self" and "not-self". Hypothetically the underlying mechanism is an error in the immunosuppressive reaction, either by a quantitative or functional diminution of so-called suppressor cells or by a lacking of antigen-specific antiidiotypic antibodies.

Antibody Formation↗
PubMed1982

[Significance of thyroglobulin as a tumor marker in the serum of patients with differentiated thyroid carcinoma: longitudinal and cross-sectional studies (author's transl)].

For evaluating the clinical significance of thyroglobulin measurements for the follow-up of patients with differentiated thyroid carcinoma, thyroglobulin was determined radioimmunologically during the past 2 years (up to 12 times) in 40 patients after withdrawal of thyroid hormone. Thyroglobulin values were compared with whole-body scintigrams after radioiodine. Thyroglobulin antibodies, which may interfere in the radioimmunoassay for thyroglobulin, were also estimated by a radioimmunologic method. In the majority of cases, thyroglobulin levels corresponded to the scintigrams, however, the thyroglobulin level appeared to be a more precise index for changes in tumor tissue mass. In one patient the scintigram was negative, whereas considerable amounts of thyroglobulin were measured in the serum: X-ray tomography revealed a lung metastase in this case. On the other hand, thyroglobulin was undetectable in the sera of patients who exhibited distinct metastases in the scintigram. Thyroglobulin can be regarded as a tumor marker in patients thyroidectomized for differentiated thyroid carcinoma. However, its determination can certainly not replace whole-body scintigraphy as postulated by several authors, although thyroglobulin measurement appears to be superior to scanning in some cases. A combined application of iodine scanning and thyroglobulin radioimmunoassay is thus advisable in the follow-up of patients with differentiated thyroid carcinoma.

Antibodies↗
PubMed1981

[Antinuclear antibodies in diagnosis of rheumatic diseases (author's transl)].

Hundred ana-positive sera--60 sera of SLE-patients and 40 sera of patients suffering from rheumatoid arthritis--were investigated for ana and DNA-antibodies. For these purposes nine different methods including several radioimmunological and immunofluorescence techniques with partially distinct antigen-specificities were tested. While the radioimmunoassays showed only slightly different results, significant differences in sensitivity as well as in antibody specificity existed mainly in the indirect immunofluorescence techniques using different substrates. For clinical use, a combination of various techniques seemed to be useful i.e. indirect immunofluorescence on hemolysed bird erythrocytes and on frozen native rat liver sections. For DNA-antibodies in diagnosis and control during the course of the diseases the radioimmunoassay with simultaneous detection of antibodies to single- and double stranded DNA is most suitable. Antibodies to distinct nuclear antigens are detectable in various amount in the rheumatic diseases. While ds-DNA-antibodies seemed to be most specific for SLE, ss-DNA-antibodies occurred in nearly all ana-positive sera and seemed to be less specific for one disease than all the other ana-fractions.

Animals↗
PubMed1981

[Reimplantation of splenic tissue after neonatal abdominal trauma (author's transl)].

Loss of the spleen in children frequently results in overwhelming infection caused by pneumococci. In order to preserve splenic function the reimplantation of splenic tissue into the abdominal wall and the greater omentum was performed in a newborn child and six other children up to the age of thirteen. Postoperatively the complete absence of Jolly's bodies could be observed, while a continuous increase of IgM was noted. The otherwise mandatory antibiotic prophylaxis over 2 years could be reduced to 5 months in the newborn.

Birth Injuries↗
PubMed1981

[Determination of thyroid hormone antibodies and their clinical relevance (author's transl)].

In 20 out of 94 cases of selected patients suffering from various thyroid diseases antibodies against thyroxine and trijodthyronine were detected. The patients were striking either because of a disturbed thyroid feed back mechanism or by the need of an increased dosage of L-thyroxine (500 microgram) for treatment. Other patients had inappropriate thyroid hormone levels not correlated to the clinical situation. Thyroid hormone-antibodies were detected using a skin test with synthetic hormones leading to an Arthus like reaction. This method turned out to be specific but not as sensitive as antibody determination by a radioimmunological technique. Hormone antibodies were reproducably detected only, when the antibodies were precipitated by anti-Ig. Using PEG or (NH4)2SO4 for antibody precipitation also other proteins such as albumin and prealbumin were found in the sediment. These proteins are able to bind thyroid hormones as well and therefore the measured activity of labelled hormones does not correspond to the selective antibody reaction with the hormone. With regard to the clinical relevance of these hormone autoantibodies it is important, to which sites of the hormones the antibodies combine. Treatment is only necessary, when patients show hypothyroid symptoms. L-thyroxin may be necessary in higher dosage than usually needed. In 4 cases therapy even with corticosteroids had to be used in order to suppress antibody production or action.

Adult↗
PubMed1979

[Diagnosis of trichinellosis and special aspects of a modified immunofluorescence test (author's transl)].

Trichinella spiralis was detected in 1835 by Paget, an English student. Since the introduction of the meat investigation law for trichinosis in 1937 the infection with this parasites became a rare condition. The last endemies in Germany occurred in 1967 and 1977. They restimulated the discussion regarding the efficiency and sensitivity of the routinely used methods for the detection of Tr. spiralis. 69 patients, suffering from infection with Tr. spiralis were investigated using a modified IFT. This method was compared with other serological techniques for the determination of Tr. spiralis and was found very sensitive and specific. Further immunological investigations showed an increased lymphocyte stimulation with Trich. antigen in most patients suffering from trichinellosis. When added autologous serum however the proliferation of lymphocytes was inhibited. The reason for this phenomenon might be a factor with immunosuppressive property produced by the adult worms.

Antigens↗