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Biomedical subjects

J Tomala

Publications and source records attributed to J Tomala.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Actuality of hysterosalpingography in women with infertility].

In 283 women with infertility HSG results have been analyzed. Fallopian tubes have been found to be patent in 196 subjects, whereas in 87 subjects distal or proximal unilateral or bilateral impatency has been observed. In 28 subjects with impatent fallopian tubes uterus malformations were found. 72 women with impatent oviducts were treated by laparoscopy alongside with oviduct chromotubation. On basis of clinical findings as well as cases reported in literature, HSG relevancy in infertility diagnostics has been proved.

Female↗
PubMed1993

[Increase of hemoglobin concentration in blood during the second trimester of pregnancy in relation to later pregnancy complications such as hypertension and intrauterine fetal growth inhibition].

The concentration of haemoglobin was determined during the second trimester of pregnancy in a group of 375 women. The mean haemoglobin concentration was significantly higher in women in whom during the third trimester of pregnancy. pregnancy-induced hypertension developed (p < 0.01). Similarly, the mean haemoglobin concentration during the second trimester of pregnancy was higher in women in whom intrauterine fetal growth inhibition was found during the third trimester. The highest haemoglobin concentration during the second trimester of pregnancy was observed in women in whom pregnancy-induced hypertension developed during the third trimester, together with intrauterine fetal growth inhibition.

Female↗
PubMed1993

Effects of two low-dose oral contraceptives on erythrocyte superoxide dismutase, catalase and glutathione peroxidase activities.

The effect of a triphasic combination of ethinyl estradiol and levonorgestrel upon activities of superoxide dismutase, catalase and glutathione peroxidase in erythrocytes was compared to that of a preparation that contained ethinyl estradiol and desogestrel on the 21st day of a control cycle, of the third cycle of treatment with ethinyl estradiol/levonorgestrel or ethinyl estradiol/desogestrel (14 volunteers each), and of the third cycle of a 3-month washout period. Significant decreases were found in the activities of superoxide dismutase, catalase and glutathione peroxidase in erythrocytes with both preparations. The effect of desogestrel on the activities of the superoxide dismutase, catalase and glutathione peroxidase is similar to that of levonorgestrel. These data suggest that low-dose oral contraceptives, by decreasing the activities of antioxidant enzymes and by enhancing the lipid peroxidation, increase the risk of cardiovascular disease.

Adult↗
PubMed1993

[Unsaturated fatty acids of trans isomers in plasma of pregnant women and birth weight].

Trans unsaturated fatty acid originated from synthetic technology. Human consumption of trans isomers of unsaturated fatty acids increased markedly. The induction of growth failure was observed in animals when trans fatty acids were supplied. We studied whether or not there are indications of untoward effects of trans fatty acids in premature infants. Trans fatty acids were in higher concentrations in plasma of 23 women in pre-term delivery compared with 21 women delivering in normal term. Trans fatty acids in plasma were also inversely correlated to birth weight and with gestational age. These data indicate a impairment of intrauterine growth by trans isomer of unsaturated fatty acids.

Birth Weight↗
PubMed1993

An imbalance between the excretion of thromboxane and prostacyclin metabolites in women after the menopause.

An increase in the incidence of cardiovascular disease has generally been observed in postmenopausal women. Because thromboxane A2 is both vasoconstrictor and a potent stimulus for platelet aggregation, it may be an important mediator of atherosclerosis. Its effects are antagonized by prostacyclin. We tested the hypothesis that there may be an imbalance between the release of thromboxane A2 and prostacyclin in women after menopause. We used radioimmunoassays to measure the 24-hour urinary excretion of two stable metabolites of thromboxane A2 and a metabolite of prostacyclin in 106 postmenopausal women and in 105 premenopausal women, both aged 45 to 55 years. The 24-hour excretion of 11-dehydro-thromboxane B2 (a stable metabolite of thromboxane A2) was increased in postmenopausal women whereas the 24-hour excretion of 2,3-dinor-6-keto-prostaglandin F1 alpha (a stable metabolite of prostacyclin) was decreased. Whether the imbalance in the release of these mediators is a cause or a result of atherosclerosis is unknown, but it may play a part in the development of this disorder.

6-Ketoprostaglandin F1 alpha↗
PubMed1992

[Changes of pituitary hormone concentration during vasomotor disorders, in blood serum of women during the early phase after surgical castration].

The behaviour of the concentration of the selected pituitary hormones during hot flushes at women after a surgical castration was evaluated. The inquiry concerned 42 women 46.7 +/- 3.4 years old, with a regular menstruation till the hysterectomy and the adnexectomy due to sexual organs diseases. The inquiry contained a determination, by means of radioimmunological methods, of the concentration of the hormones: LH, FSH, PRL, HGH, TSH in the blood serum taken at women 48 hours before the operation, on the 8th day after the intervention and 5 min after the hot flushes apparition. At the same time, the finger skin temperature and the pulse rate was taken. The rise in the finger skin temperature by 1.2 degrees C and the mean rise in the pulse rate by 11.3 beats/min during hot flushes were noticed. An important increase of the LH and HGH concentration during hot flushes was also observed.

Adult↗
PubMed1992

[Zinc concentration in human semen of men from childless marriages].

Zinc concentration in human semen was studied on the material of 106 male patients aged 20-35, from childless marriages. Full microscopic examination was performed including number of spermatozoa mobility, flux time, pH, morphological composition, number of leucocytes. Zinc level was measured using spectrophotometric analysis. Trial of relation estimation between zinc concentration and number of live spermatozoa and pH of the semen was taken out. Any significant differences between zinc concentration in the semen from normospermic and oligospermic males were found. There was proved, that semen pH increase was correlated to zinc concentration decrement in the semen fluid.

Adult↗
PubMed1989

Zinc, magnesium and copper in serum of women given a calcium supplement.

Earlier investigators have demonstrated in animal studies interrelationships between mineral elements. Serum zinc, magnesium and copper were monitored over a two year period in 120 women between the ages of 40 and 55 years. One group (65 women) was supplemented with calcium, the other served as a control. We concluded that calcium supplementation at a level of 1,500 mg Ca mainly does not affect serum zinc, magnesium and copper, however, serum copper concentration is elevated in women taking medication for hypertension.

Administration, Oral↗
PubMed1989

Placental phospholipase A2 activities in pre-eclampsia.

Phospholipase A2 activity was significantly increased in placental homogenates from 22 patients with preeclampsia in comparison to placental homogenates from women with uncomplicated pregnancy. Such an abnormality may be responsible for a altered release of free arachidonic acid, thus playing a major role in the pathogenesis of this syndrome.

Adolescent↗
PubMed1989

[Concentration of selenium and vitamin E in the serum of women with malignant genital neoplasms and their family members].

Lower concentrations of selenium and vitamin E were found in the serum of 50 women with malignant neoplasms of the genitals as compared with the concentrations in 55 healthy women family members of the patients living with them in common households. The degree of concentration decrease of these substances in the serum depended on the location of the tumour, and in cases of cervical neoplasms was 28% for selenium and 12% for vitamin E of the values in controls while in cases of ovarian neoplasms it was 34% and 37% respectively and in endometrial tumours it was 40% and 23% respectively. The third studied group comprised 36 healthy subjects not belonging to the families of the patients. The highest concentrations of selenium and vitamin E were found in the serum in the third group of women. The results suggest that various family factors not analysed in this study affect the concentrations of selenium and vitamin E in the serum of women with malignant neoplasms of genitals and in their family members.

Adult↗