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Biomedical subjects

J Urwin

Publications and source records attributed to J Urwin.

6 recordsLinked to original sources

Current issues in contraception.

This article discusses the currently available methods of contraception and their advantages and disadvantages. It relates to UKCC Professional Development categories Care enhancement and Reducing risk.

Choice Behavior

Particle size stability of intralipid and mixed total parenteral nutrition mixtures.

The determination of the particle size of Intralipid fat emulsions by the non-perturbing method of photon correlation spectroscopy has been extended to include particle size determination using the Coulter counter and optical microscopy. Although little increase in particle size in 3-litre bags containing total parenteral nutrition mixtures was observed with the methods involving large dilutions, creaming was observed and optical microscopy showed aggregation and some coalescence to have taken place. The problem of re-dispersion upon dilution of aggregated (but not coalesced) fat emulsions makes direct optical observation essential in assessing the stability and safety of such fat emulsion mixtures. The effect of electrolytes (NaCl and CaCl2) on creaming, particle size and electrophoretic mobility showed both minimum stability and minimum zeta potential at 3 X 10(-3) mol dm-3 CaCl2 and at 2.5 X 10(-1) mol dm-3 NaCl. Thus, these maximum levels for electrolytes in total parenteral mixtures are indicated.

Adult

Atracurium: conception and inception.

The rationale underlying the design of atracurium, a bis-quaternary ammonium neuromuscular blocking agent which incorporates the Hofmann elimination as a novel biodegradation pathway, is described. Destruction in vivo, of the bis-quaternary structure essential for neuromuscular blocking activity, by the combination of Hofmann elimination and a parallel ester hydrolysis leads to innocuous breakdown products that are without neuromuscular or cardiovascular effects and to a time-course of action which is unaffected by the level of plasma esterase activity, renal or hepatic function.

Animals

Writing the changes for nurses.

Prescribing powers for family planning nurses has been a heated and topical issue for decades and progress has been impossibly slow. Jane Urwin wonders if this extended role for nurses will ever materialise.

Adult