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PubMed · 6688014

Atracurium: conception and inception.

J B Stenlake·R D Waigh·J Urwin·G H Dewar·G G Coker
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Abstract

The rationale underlying the design of atracurium, a bis-quaternary ammonium neuromuscular blocking agent which incorporates the Hofmann elimination as a novel biodegradation pathway, is described. Destruction in vivo, of the bis-quaternary structure essential for neuromuscular blocking activity, by the combination of Hofmann elimination and a parallel ester hydrolysis leads to innocuous breakdown products that are without neuromuscular or cardiovascular effects and to a time-course of action which is unaffected by the level of plasma esterase activity, renal or hepatic function.

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AnimalsAtracuriumBiotransformationHumansIsoquinolinesNeuromuscular Blocking AgentsStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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J B Stenlake, R D Waigh, J Urwin, G H Dewar, G G Coker. 1983. Atracurium: conception and inception.. https://pubmed.ncbi.nlm.nih.gov/6688014/

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