Biomedical subjects

J Visfeldt

Publications and source records attributed to J Visfeldt.

At least 73 records · Page 4Linked to original sources

PubMed1975

Histology of the human corpus luteum of early and late pregnancy.

The aim of this investigation has been to examine which histological parameters are of value in the age determination of the corpus luteum of pregnancy. The material comprises representative ovarian biopsies from 16 women from the 10th through 42nd week of gestation. The following histological parameters have been found useful for the age determination of the corpus luteum: 1) the size of the granulosa cells; 2) the number of K-cells, vacuoles and colloid inclusions in the granulosa cell layer; 3) the size of the theca interna cells; (4) the size of the vessels in the theca interna. Futhermore, the differentiation of the corpus luteum of pregnancy from the corpus luteum of menstruation is described, and some indications for a histological age determination of the corpus luteum of pregnancy are mentioned.

Adolescent↗

PubMed1975

Growth patterns and chromosome constitutions of human malignant tumours after long-term serial transplantation in nude mice.

Five human malignant tumours, heterotransplanted to athymic nude mice, have been re-investigated after long-term serial transplantation, and their growth patterns and chromosomal constitutions compared with their early appearance. After 27-56 passages over 3 1/2--5 1/2 years, all of the tumours--two adenocarcinomas of the colon, two malignant melanomas, and one Burkitt's lymphoma--retained the cytological and histological appearance of the inoculated human material. All the mitoses observed in the chromosome studies were of human karyotype. The fact that no total chromosomal species shift, no interspecies hybridization, and no changes in biological properties appeared--as observed in some other heterotransplantation systems--would indicate that human tumours grafted to nude mice are more suitable models in, e.g., studies concerning cancer chemotherapeutics.

Adenocarcinoma↗

PubMed1975

On thorotrast leucaemia. Evolution of clone of bone marrow cells with radiation-induced chromosome aberrations.

Results are presented of chromosome studies of bone marrow cells from a 62-year-old woman. The patient had been given 40 ml of Thorotrast in connection with a neuro-radiological examination 34 years earlier. Clinically, the patient was now considered to be in an incipient myeloid leucaemic phase. Ninety-seven per cent of the bone marrow cells belonged to a clone with characteristic marker chromosomes induced by radiation. Few data are available on chromosome analysis of bone marrow cells from Thorotrast patients. Therefore, the results of the present study are compared with data from chromosome analyses of 32P-treated patients with polycythaemia vera, in whom large clones were found in the bone marrow. The results of chromosome analysis of bone marrow cells from the Thorotrast patient support previous hypotheses concerning the carcinogenesis in radiation-induced leucaemia in patients with polycythaemia vera, treated with 32P. In the latter patients, the clone cells are pressumed to represent cell populations with selective qualities, originating from radiation-damaged cells, which possibly possess an increased tendency to malignant transformation because of a more pronounced sensitivity to carcinogenic agents. The cells might also be potentially malignant and manifest themselves as leucaemic cells, if the patient's immunological defence mechanism is broken.

Bone Marrow↗

PubMed1974