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Biomedical subjects

J W Patterson

Publications and source records attributed to J W Patterson.

At least 91 records · Page 5Linked to original sources
PubMed1986

Bowenoid papulosis. A clinicopathologic study with ultrastructural observations.

One hundred eight patients were studied who had anogenital lesions showing microscopic features as seen in bowenoid papulosis (BP), a recently described condition occurring most commonly in young adults. Patients typically show multiple papules, small nodules, or plaques that clinically mimic verrucae or nevocellular nevi. Although the lesions show microscopic cytologic atypia, a distinction from Bowen's disease, erythroplasia of Queyrat, and other forms of carcinoma in situ can usually be made on the basis of histologic and clinical criteria. The disorder responds to conservative treatment, although recurrences are not uncommon. Evolution of the lesions to invasive carcinoma was not observed. Mounting evidence links the development of BP to infection with human papilloma virus, but other viruses, as well as hormonal and immunologic factors, may also play a role.

Adolescent↗
PubMed1986

An extracellular body of plasma cell origin in inflammatory infiltrates within the dermis.

During examination of a biopsy specimen of skin by conventional microscopy, numerous round, basophilic, extracellular bodies suggestive of fungal organisms were seen in the dermis. Further evaluation and special staining suggested that their origin was from the plasma cells. Examination of biopsy material from 48 patients with cutaneous plasma cell infiltrates revealed similar bodies in 20 cases (42%). Sizes of bodies varied, the largest being 5.0 microns in diameter. In every case, staining reactions were identical to those of plasma cell cytoplasm. Immunoperoxidase methods showed that, like plasma cells, the bodies contained either kappa or lambda light chains. In one case of plasmacytoma associated with multiple myeloma, both the bodies and the surrounding neoplastic cells stained for kappa chains only. Electron microscopy revealed rounded structures composed of aggregates of rough endoplasmic reticulum, which contained varying amounts of moderately electron-dense material within the cisternae. Fragmented plasma cells were also seen. The evidence suggests that plasma cell bodies are distinct from Russell bodies. They probably form as a result of trauma during processing of tissue, but could also represent a degenerative process in vivo. They should be distinguished from pathogenic micro-organisms and other extracellular bodies.

Adult↗
PubMed1986

Lymphomatoid papulosis.

In this review, we discuss the clinical and histologic features of lymphomatoid papulosis, a cutaneous disorder characterized by recurrent eruptions of self-healing papules and small nodules with histologic findings suggestive of malignant lymphoma. Possible causes of this peculiar disease are discussed in the light of recent investigation. Recognition is important to avoid misdiagnosis and overly aggressive therapy, but it should be remembered that a small number of cases have been reported to progress to malignant lymphoma.

Adult↗
PubMed1986

Extraskeletal Ewing's sarcoma with cutaneous involvement.

We report the case of a 13-year-old girl with extraskeletal Ewing's sarcoma involving the skin and subcutaneous tissue of the upper back. The patient underwent wide local excision and right axillary node dissection, and received chemotherapy with vincristine, actinomycin D, and cyclophosphamide. There was no evidence of recurrence or metastasis in eight months of follow up. Light and electron microscopic features were typical for this neoplasm. Tumor cells contained abundant glycogen, but failed to stain for desmin, keratin, neuron-specific enolase, or S-100 protein. We discuss the differential diagnosis of extraskeletal Ewing's sarcoma as well as theories of its histogenesis.

Adolescent↗
PubMed1986

Distant skin metastases in a long-term survivor of malignant ameloblastoma.

We report a case of distant cutaneous metastases in a 68-year-old patient with malignant ameloblastoma of the mandible. The metastatic lesions were first noted approximately 31 years after resection of the primary tumor. Metastases to lung, pleura, bone, and brain had also occurred. Histochemical findings differ from those described in adamantinoid basal cell carcinoma. Cutaneous metastasis probably resulted from hematogenous dissemination. To our knowledge, this is the first report of such an occurrence in English language literature.

Aged↗
PubMed1986

Malignant histiocytosis presenting with vasculitis and cutaneous erythrophagocytosis.

We report a case of malignant histiocytosis that presented initially as a cutaneous vasculitis without malignant features. A subsequent biopsy specimen of an erythematous skin lesion showed erythrophagocytosis by normal-appearing histiocytes within the subcutis. The recognition of erythrophagocytosis was followed by systemic symptoms and signs of malignant histiocytosis and a rapidly deteriorating clinical course. Possible mechanisms for erythrophagocytosis are discussed, and other diseases associated with this histologic finding are reviewed briefly.

Adult↗
PubMed1985

Cutaneous involvement in Hodgkin's disease.

Among 465 patients with Hodgkin's disease seen from 1951 through 1980, there were 16 (3.4%) who had histologically verified "specific" cutaneous involvement with Hodgkin's disease. The most common clinical presentation was of single or multiple dermal or subcutaneous nodules. Three patients had skin lesions at first presentation. In all instances, it was possible to classify the cutaneous histologic pattern using the Rye Classification. In addition, one patient was seen in whom disease was confined to a localized area of skin and subcutaneous tissue. This case was difficult to classify, although there were some histologic features suggestive of lymphocyte-depletion Hodgkin's disease. The findings indicate three mechanisms of cutaneous involvement: (1) retrograde lymphatic spread, distal to involved lymph nodes (11 patients); (2) direct extension from an underlying nodal focus (3 patients); and (3) hematogenous dissemination (2 patients). Cutaneous involvement usually represents, or accompanies, Stage IV disease, and carries an ominous prognosis. The problems inherent in the diagnosis of primary cutaneous Hodgkin's disease are discussed.

Adolescent↗
PubMed1985

Bullous pemphigoid. Occurrence in a patient with mycosis fungoides receiving PUVA and topical nitrogen mustard therapy.

A 57-year-old woman with mycosis fungoides developed blisters within cutaneous plaques while receiving PUVA therapy and topical nitrogen mustard. Direct and indirect immunofluorescence studies showed the findings of bullous pemphigoid. Her bullous disease was controlled after cessation of these therapies and institution of prednisone and methotrexate. During the 5 months following completion of a course of electron-beam therapy, she has been free of the cutaneous manifestations of both diseases. Previous instances of PUVA-related pemphigoid have occurred in psoriatics. The role of ultraviolet light in the induction of pemphigoid is discussed, particularly with regard to its possible interaction with the altered skin of psoriasis or mycosis fungoides. Some of the rare cases of bullous mycosis fungoides might actually have represented ultraviolet-unmasked bullous pemphigoid.

Administration, Topical↗
PubMed1985

Localization of potassium and sodium fluxes in the rat lens.

A three chambered Ussing-type apparatus was devised so that a lens could be exposed to test media at the anterior surface, the posterior surface, and the equatorial surface. Potassium and sodium fluxes were estimated with double isotope labeling. 86Rb, which behaves like potassium, or 22Na were used for flux measurements, and 3H-inulin was used to correct for extracellular space and to rule out leakages of medium between compartments. Lenses were paired in media with and without ouabain. In the absence of ouabain, 86Rb influx is greater at the anterior and equatorial surfaces than it is at the posterior surface. In the presence of ouabain, the differences in 86Rb influx are less pronounced. In the absence of ouabain, the net efflux of 86Rb at the anterior and equatorial surfaces, but not at the posterior surface, is less (P less than 0.01) than it is in the presence of ouabain. In the presence of ouabain, 86Rb efflux is the same at each of the surfaces. 86Rb efflux is not altered if the medium is changed every 30 min to decrease the uptake of isotope that is entering the medium while the efflux is being measured. 86Rb efflux is tripled in a Ca-free medium and the increase is limited to the surface that is exposed to the Ca-free medium. 22Na uptake from the posterior or anterior surface is the same in the presence or absence of ouabain. 22Na uptake from the anterior or the posterior surface results in an accumulation of 22Na in the equatorial chamber.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1985

Infundibular and trichilemmal keratinization of a pilar tumor.

Microscopic examination of a cystic epithelial tumor removed from the elbow of a 52-year-old man showed islands of epithelium undergoing keratinization without formation of a visible granular cell layer, as occurs within the follicular isthmus, in trichilemmal cysts, and in pilar tumors (proliferating trichilemmal cysts). Other areas showed keratinization with the formation of a distinct, even prominent, granular cell layer, as seen within the follicular infundibulum and in epidermal cysts. Possible modes of origin and relationships among these tumors and epidermal cysts are presented.

Epidermal Cyst↗
PubMed1985

Nodular colloid degeneration: distinctive histochemical and ultrastructural features.

We recently evaluated a patient with a unique form of nodular colloid degeneration. Lesions consisted of pruritic, purpuric plaques involving the upper and lower extremities and the neck. Examination of a biopsy specimen revealed large, fissured masses of amorphous material in addition to solar elastosis. The amorphous material showed negative reactions to stains for amyloid, and other histochemical studies showed results similar to those for colloid milium. The amorphous masses demonstrated a marked positive reaction to the Verhoeff-van Gieson stain for elastin. Electron microscopic examination revealed masses of degenerated elastic tissue bordered by fibrillar material that resembled amyloid morphologically. We believe this case represents a nodular form of solar degeneration with clinical and histologic resemblances to both colloid milium and cutaneous amyloidosis.

Amyloidosis↗
PubMed1985

Effects of calcium on the steady outward currents at the equator of the rat lens.

The relationships between calcium and the steady outward currents at the equator of the rat lens were studied using the vibrating probe technique. In a calcium-free medium, the current was greatly increased and it returned to its original level when calcium was restored to the medium. The Ca-free effect was not observed in Na-free medium. Iodoacetate (IAA) inhibited the initial current, but a current then returned which is referred to as a secondary current. The secondary current was not observed in a Ca-free medium and, therefore, it is thought to be a calcium-dependent potassium current. These responses are consistent with effects on potassium efflux measured by others and lend support to the interpretation that the outward currents observed at the equator of the rat lens are potassium currents. The currents are partially inhibited but not abolished in Na-free bathing medium. This is consistent with the view that the inward currents at the optical poles may be related to the influx of sodium.

Animals↗
PubMed1985

Superficial ulcerating rheumatoid necrobiosis: a perforating rheumatoid nodule.

We report a case of superficial ulcerating rheumatoid necrobiosis (SURN), which is a recently described cutaneous manifestation of severe rheumatoid arthritis. As with classic rheumatoid nodule, there is evidence that this lesion may result from a vasculitis. SURN appears to represent a form of "perforating" rheumatoid nodule, and completes a triad of major necrobiotic processes (granuloma annulare, necrobiosis lipoidica, rheumatoid nodule) that have been reported to show epidermal perforation.

Arthritis, Rheumatoid↗
PubMed1984

The perforating disorders.

This article reviews the diseases that may show epidermal perforation as a histologic feature. Many of these represent examples of transepithelial elimination (TEE), a mechanism by which the skin rids itself of abnormal substances. After a review of disorders in which perforation is an occasional finding, four diseases that have been considered essential perforating disorders are discussed: elastosis perforans serpiginosa (EPS), reactive perforating collagenosis (RPC), perforating folliculitis (PF), and Kyrle 's disease (KD). A review of the literature, including recent reports of perforating diseases associated with chronic renal failure, suggests that there may be considerable clinical and histologic overlap among PF, KD, and the adult form of "perforating collagenosis." A working classification for the perforating disorders is suggested.

Collagen Diseases↗
PubMed1984

Keratosis punctata palmaris et plantaris and adenocarcinoma of the colon. A possible familial association of punctate keratoderma and gastrointestinal malignancy.

We report a patient with keratosis punctata palmaris et plantaris who developed adenocarcinoma of the colon. Family history revealed at least seven other individuals with punctate keratoderma. The patient's mother had punctate keratoderma and carcinoma of the colon, and his maternal grandfather had punctate keratoderma and carcinoma of the pancreas. This is the third reported family, to our knowledge, in which hereditary palmar and plantar hyperkeratosis appears to be associated with gastrointestinal carcinomas.

Adenocarcinoma↗