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Biomedical subjects

J W Patterson

Publications and source records attributed to J W Patterson.

At least 109 records · Page 6Linked to original sources
PubMed1984

Extramammary Paget's disease. Arising in knee region in association with sweat gland carcinoma.

We report a case of extramammary Paget's disease (EMPD) arising in the knee region in association with an underlying sweat gland carcinoma. Inguinal lymph node metastases were present initially. Paget's cells, intradermal tumor cells, and metastatic tumor cells showed similar reactions to a variety of histochemical stains and positive results with immunohistochemical staining using carcinoembryonic antigen (CEA). Control sections in cases of Bowen's disease and superficial, spreading malignant melanoma showed a negative staining reaction with CEA, providing further evidence that this technique is useful in distinguishing Paget's disease (PD) from histologically similar conditions. We provide a summary of previous cases of EMPD arising in unusual locations and a brief consideration of possible mechanisms of the origin of PD.

Adenocarcinoma↗
PubMed1984

Presternal ciliated cyst.

We report the case of a presternal ciliated cyst in a 39-year-old man. The location and histologic features of this lesion have led us to favor a primitive foregut origin for this cyst, probably via the process of embryonic sequestration and migration.

Adult↗
PubMed1983

Volume regulation in rat lenses in media with varying concentrations of potassium and sodium.

The concentrations of sodium and potassium, the distribution of 36Cl, the content of water and the 86Rb influx were determined in four sets of rat lenses in 185, 245, 305 and 365 mosmol media. In each set, the potassium content was varied by substituting potassium for sodium in modified TC-199 media. The lenses were incubated in the media for 24 hr in order to approximate steady-state conditions. The results in the low potassium range (less than 21 mM K) are quite different from those in the high potassium range (21-125 mM K). In the high potassium range the lens volume is dependent on the concentration of sodium in the medium and the content of potassium is controlled by the concentration of potassium in the medium. There is no volume regulation in this range and the distribution of potassium approximates levels expected in a Donnan equilibrium. In the low potassium range, the content of electrolyte in the lens is at a higher level than would be expected from an extrapolation of the observations in the high potassium range. The equilibrium constant (EK) for potassium exceeds the estimated membrane potential (PD) so that an active process is probably responsible for the elevation of potassium content in the low potassium range. The Na+-, K+-pump is stimulated by potassium and by sodium in the medium. It is postulated that volume regulation in anisotonic media is the result of the gain or loss of solute as the lens changes from one steady-state to another with the concentration of sodium chloride in the medium acting as a trigger and determining the extent of the effect.

Animals↗
PubMed1983

Subacute myelomonocytic leukemia--an unusual skin manifestation.

This case report concerns a 44-year-old woman with subacute myelomonocytic leukemia who developed an unusual bullous lesion on her leg. Initially treated as a bacterial ecthyma, this lesion proved to be a specific leukemic infiltrate. We will briefly review myelomonocytic leukemia and the skin findings of the myeloid leukemias.

Adult↗
PubMed1983

What's new in dermatopathology?

This review emphasizes the important work in dermatopathology reported in the past 3 years. In reviewing the recent contributions in the field, four areas appear to have received particular attention: (1) new information concerning the histogenesis of cutaneous tumors based on the dual functional capacities of cells; (2) the Langerhans cell and its role in inflammatory and neoplastic processes; (3) prognostic factors in stage I malignant melanoma; and (4) the use of new immunofluorescent and immunohistochemical technics as diagnostic tools in cutaneous pathology.

Carcinoma↗
PubMed1983

35S-methionine incorporation in rat lenses in media simulating cataractogenic conditions.

Lenses obtained from rats on a galactose diet for six days showed a marked reduction in their capacity to incorporate 35S-methionine into protein even though there was no reduction in the capacity of the lenses to incorporate 3H-thymidine and 3H-uridine into DNA and RNA, respectively. Therefore, lenses were incubated in media in which various putative cataractogenic factors were varied to determine the effects on 35S-methionine incorporation. Methionine incorporation paralleled the size of the AIB pool rather than the chloride ratio or concentration of potassium in the lens. The size of the amino acid pool and the concentration of lens potassium are known to be lowered by lens swelling. When the concentration of potassium in the lens is lowered, along with swelling in hypotonic medium or in medium containing galactose, or when the concentration of potassium is lowered with little swelling by substitution of choline for some of the sodium in the medium. 35S-methionine incorporation is decreased. However, this decrease in 35S-methionine incorporation was prevented in all cases without a significant increase in potassium concentration if the medium was fortified with amino acids. Increasing the level of potassium in the medium increased the concentration in the lens to normal levels. However, 35S-methionine incorporation was not increased in media containing galactose or choline.

Animals↗
PubMed1982

Perforating folliculitis and psoriasis.

A 51-year-old man with a 10-year history of psoriasis presented with coexistent perforating folliculitis. Several perforating lesions were located within psoriatic plaques. This case is instructive from several viewpoints: (1) it is the second case to appear in the literature, to our knowledge, describing the coexistence of these two conditions; (2) several of the larger lesions resolved during topical therapy with retinoic acid; (3) it demonstrates the histologic difficulties encountered in attempting to classify the major perforating diseases. Possible mechanisms for the development of perforating disease in this patient are discussed, as are the reasons for its apparent response to topical therapy.

Administration, Topical↗
PubMed1982

Treatment of multiple keratoacanthomas with intralesional fluorouracil.

A keratoacanthoma is a benign epithelial growth most often found in sun-exposed skin of the elderly. Two main groups of multiple keratoacanthomas have been described: the Ferguson-Smith type and the Grzybowski type. A patient with multiple keratoacanthomas of the Ferguson Smith type is described and the treatment with intralesional 5-fluorouracil is explained. Intralesional therapy with 5-fluorouracil is a safe treatment and may be the treatment of choice for multiple keratoacanthomas and solitary lesions which are difficult to remove surgically.

Fluorouracil↗
PubMed1982

Treatment of hypopigmented sarcoidosis with 8-methoxypsoralen and long wave ultraviolet light.

A patient with hypopigmented sarcoidosis involving the face was treated with topical 8-methoxypsoralen and long wave ultraviolet light. Satisfactory repigmentation occurred within eight months of tri-weekly therapy. Electron microscopic study of involved, untreated skin showed abnormalities of melanocytes, including cytoplasmic vacuolization and the presence of melanosome complexes. Treated skin showed sparsity of melanosomes within the central portions of some melanocytes and large numbers of melanosomes within melanocytic dendrites. The clinical and ultrastructural findings suggest the possibility of toxic damage to melanocytes, perhaps with abnormalities of melanosome transfer, in lesions of hypopigmented sarcoidosis. These abnormalities appear to be responsive to psoralen-UVA therapy.

Adult↗
PubMed1982

Distribution of potassium in the rat lens.

Rat lenses were incubated for 24 hr in media with various concentrations of potassium and a constant concentration of sodium. The media were prepared by adding potassium chloride to a basic 300 mOsm TC-199 medium. Concentrations of potassium up to 100 mM were produced with a maximum osmolarity of 500 mOsm. The content of lens water remained constant in all media even though the content of potassium doubled and the lens was depolarized. The findings support the view that the content of lens water is determined by the concentration of sodium and that potassium acts like a permeant ion. The loss of potassium in the presence of ouabain during a 24 hr period is about twice as great as it is in a potassium-free medium in the absence of ouabain. This is taken as evidence for the recycling of potassium.

Animals↗
PubMed1981

Mechanism for the oxidative defluorination of flunisolide.

Flunisolide (6 alpha-fluoro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide) was converted to 6 beta,- 11 beta, 16 alpha, 21-pentahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide (6 beta-OH metabolite) by mouse liver microsomes, but no activity was observed with mouse lung, intestine or kidney microsomes. Two additional metabolites of flunisolide also formed by mouse hepatic microsomes were identified by mass spectral analysis to be 11 beta, 16 alpha, 17 alpha,21-tetrahydroxypregna-1,4-diene-3,6,20-trione-16,17-acetonide (6-keto metabolite) and delta 6-flunisolide. The formation of all three metabolites required NADPH, was inhibited by carbon monoxide and was stimulated by pretreating mice with phenobarbital. A time-couse study suggested the 6-keto metabolite was an intermediate in the formation of the 6 beta-OH metabolite. When added to microsomes, the 6-keto metabolite was converted to the 6 beta-OH metabolite by a carbon monoxide-insensitive enzyme. Our results suggest the conversion of flunisolide to the 6 beta-OH metabolite is catalyzed by a multi-enzyme pathway via a stable intermediate, the 6-keto metabolite. The initial reaction which leads to the formation of the 6-keto metabolite is catalyzed by a cytochrome P-450-mediated microsomal monoxygenase(s), but the reduction of the 6-keto metabolite to the 6 beta-OH metabolite is cytochrome P-450-independent.

Animals↗
PubMed1981

The effect of ouabain on volume regulation in the rat lens.

In an anisotonic medium the tendency of the lens to swell or shrink in response to the osmotic gradient is countered by a change in the content of lens solute, so that the change in the volume of lens water is minimal. This phenomenon is known as volume regulation. The rapid phase of volume regulation occurs in less than 1 hr and is followed by a slower phase that may require about 36 hr. In the present study the changes in the content of water, potassium and sodium were measured in the presence and absence of ouabain during 1 hr of incubation in anisotonic media. The effects of the ouabain-insensitive components of fluxes along electrochemical gradients are indicated by changes in the presence of ouabain, and the effects attributable to an active pump by the difference in changes in the presence and absence of ouabain. The results indicate that the volume of the lens after the initial phase of volume regulation is the same in the presence and absence of ouabain, that sodium influx varies with osmotic change, that the degree of sodium change cannot be accounted for by changes in the electrochemical driving force, that the sodium permeability is apparently decreased in hypotonic media and increased in an hypertonic medium, and that the changes in sodium influx can account for other changes associated with volume regulation.

Animals↗
PubMed1979

Localized tick bite reaction.

A woman presented with a localized tick bite reaction. The tick (Amblyomma americanum, the "lone star" tick) was still attached to the erythematous, indurated skin of the upper back. After several unsuccessful attempts at removal, a punch biopsy was performed, and the resultant histologic sections incorporated both tick and involved skin. The various systemic and localized tick bite reactions are discussed, as are the diagnostic dilemmas which may arise when the organism is no longer present. Punch biopsy is suggested as an effective means of removing the organism.

Aged↗