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Biomedical subjects

J W Shigeoka

Publications and source records attributed to J W Shigeoka.

At least 19 recordsLinked to original sources

Home oxygen therapy under Medicare. A primer.

Medicare recently implemented a new, strict, and complex home oxygen policy and a new oxygen prescription form. Unfortunately, the lack of instructions for the form has led to confusion, frustration, and suboptimal treatment. Long-term oxygen therapy prolongs survival, ameliorates hypoxic organ dysfunction, and improves exercise endurance. Indications for therapy include hypoxemia caused by cardiopulmonary diseases, hypoxemia that occurs with sleep or exercise, and hypoxemic organ dysfunction. Patients should be stable and have an arterial blood oxygen tension (PaO2) of 55 mm of mercury (7.3 kPa) or less or arterial blood oxygen saturation (SaO2) of 88% or less. There should be evidence of hypoxic organ dysfunction when the (PaO2) is 56 to 59 mm of mercury (7.4 to 7.8 kPa) or the SaO2 is 89%. A medical review by the insurance carrier is required if oxygen is to be prescribed when hypoxemia is less severe--if the PaO2 is 60 mm of mercury (8.0 kPa) or more or if the SaO2 is 90% or more. The instructions for oxygen flow, duration, and equipment must be explicit to ensure adequate therapy. An oxygen concentrator with a small oxygen cylinder portable system fulfills most needs. Oxygen cylinders may be used at low flows for patients who require therapy only during sleep or where electrical power is unreliable. A liquid oxygen system may be prescribed for active patients. Portable equipment should be provided in addition to stationary equipment when patients have resting hypoxemia. Portable equipment alone is sufficient when there is exercise-related hypoxemia with normal oxygenation at rest. Newly developed oxygen-conserving devices may offer longer ambulatory times and possibly lower operating costs. When home oxygen therapy is started in the hospital, the Certificate of Medical Necessity should be completed and patients should be trained to use the equipment before discharge.

Centers for Medicare and Medicaid Services, U.S.↗

Aerobic capacity of older adults: a training study.

The effects of a four month aerobic conditioning program on heart rate, blood pressure, maximal oxygen consumption (VO2max), and physical work capacity of 55-70 year old sedentary individuals were evaluated. Twenty-eight men and women participated in either 4 months of supervised fast walking or jogging at a prescribed target heart rate or stretching exercises for one hour, three days per week. Gains in VO2max (ml/kg/min) obtained during a Balke maximal treadmill test in aerobic and exercise control subjects were 27% and 9%, respectively. At posttesting subjects in both groups demonstrated improved maximal work rate, increased treadmill time, and experienced lower resting and recovery heart rates, lower resting systolic blood pressure, and fewer premature ventricular depolarizations during exercise testing. In 67 physician-supervised maximal exercise tests, only one subject did not achieve VO2max due to exercise induced arrhythmias. No events of morbidity or mortality occurred as a result of the exercise testing and training. Subjects were contacted 4 years after study participation to determine if they were adhering to an exercise program. Sixty-four percent reported exercising at least 3 days per week in large muscle activities. We conclude that four months of supervised aerobic and nonaerobic exercise training is sufficient to improve aerobic capacity and other indicators of fitness in older, sedentary men and women, and that these previously sedentary people are likely to continue exercising on an individual basis once they have experienced improved physical capacity.

Aged↗

Cardio-respiratory fitness of young and older active and sedentary men.

Physiological profiles are described for 30 healthy young (20-31 years) and 30 healthy older (50-62 years) men. Half of the individuals in each group reported that during the previous five years they participated frequently in strenuous physical exercises; the other half reported sedentary lifestyles. A treadmill exercise test was used to determine maximal aerobic power (VO2 max). Heart rate and blood pressure were measured during rest, maximal exercise and recovery. The active older men demonstrated significantly lower resting heart rates, lower resting systolic and diastolic blood pressures, higher VO2 max, lower maximal exercise diastolic blood pressure and lower recovery heart rates than the age-matched sedentary men. Compared with the young sedentary men, the older active men had lower resting heart rates and higher VO2 max, walked longer on the treadmill, had lower recovery heart rates and weighed less. Older active men also had higher VO2 max levels than young sedentary men. In summary, physiological profiles of the older active men more closely resembled profiles of active men who were 30 years younger than those of older sedentary men. These results emphasize the range of benefits associated with exercise.

Adult↗

Pulmonary telangiectasia without hypoxemia.

We describe an elderly patient with an unusual presentation of hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease) involving the lung. He had recurrent "pneumonia" caused by massive hemorrhage from endobronchial telangiectases. When stable, he was normoxic, had no evidence of right-to-left shunting, and had mild pulmonary arterial hypertension. His pulmonary telangiectases may be isolated to the bronchial circulation. We report hemodynamic data and show the first photographs of endobronchial telangiectases.

Aged↗

Effect of normoxemic and hypoxemic exercise on renin and aldosterone.

Five subjects (group 1) performed progressive treadmill exercise on 2 separate days, once while breathing room air (normoxemic) and the other time while breathing gas with a fractional inspired O2 of 17% (hypoxemic). Five other subjects (group 2) performed two progressive treadmill exercise tests on each of 2 separate days in a crossover design. On 1 day normoxemic exercise was first, followed by hypoxemic exercise, and on the other day the pattern was reversed. Plasma renin activity (PRA) increased to a similar extent with hypoxemic exercise as with normoxemic exercise. Plasma aldosterone concentrations (PAC) rose to a significantly higher level during normoxemic exercise than with hypoxemic exercise. Comparing changes in PRA to PAC with progressive exercise revealed dissociation of PAC from PRA during hypoxemic exercise. The PAC response remained depressed when normoxemic exercise followed hypoxemic exercise. These results indicate that hypoxemia interferes with PRA-mediated aldosterone secretions. The mechanism of this inhibition is unclear.

Adolescent↗

Zeolite exposure and associated pneumoconiosis.

Naturally occurring zeolite minerals are aluminum silicates widespread in the earth's crust. Several of these minerals have fibrous forms and have been implicated as a possible cause of benign and malignant diseases of the lung and pleura in Turkey. This report describes a patient, living in an area of Nevada rich in zeolites, who presented with idiopathic pleural thickening and pulmonary fibrosis associated with extensive pulmonary deposition of zeolites.

Aluminum Silicates↗

Concomitant pulmonary thromboembolism and metallic mercury embolism. A diagnostic dilemma.

The concomitant occurrence of mercury emboli and thromboemboli of the lung has not been previously reported. We describe the case of an intravenous drug abuser with chest pain and newly discovered mercury emboli in the lung who was found to have a thromboembolus in the right pulmonary artery. An echocardiogram showed metallic density in the right ventricle, which has not been demonstrated previously.

Adult↗

Aerobic exercise training and improved neuropsychological function of older individuals.

The effects of a four month aerobic exercise conditioning program on neuropsychological test performance, depression indices, sensory thresholds, and visual acuity of 55-70 year old sedentary individuals were evaluated. Aerobically trained subjects were compared with two age-matched control groups of subjects: those who trained with strength and flexibility exercises and others who were not engaged in a supervised exercise program. The aerobically trained subjects demonstrated significantly greater improvement on the neuropsychological test battery than did either control group. Depression scores, sensory thresholds, and visual acuity were not changed by aerobic exercise. The pattern of results suggests that the effect of aerobic exercise training was on central rather than on peripheral function. We speculate that aerobic exercise promoted increased cerebral metabolic activity with a resultant improvement in neuropsychological test scores.

Aged↗

Disinfection of the flexible fibreoptic bronchoscope against Mycobacterium tuberculosis and M gordonae.

In view of recent reports of contamination of the fibreoptic bronchoscope by tuberculous and non-tuberculous mycobacteria, we evaluated the disinfecting properties of aqueous glutaraldehyde (Cidex) and an iodophor (Prepodyne) against Mycobacterium tuberculosis and M gordonae. We found that a 15 minute disinfection procedure with either agent, coupled with initial vigorous mechanical cleaning of the bronchoscope and its accessories, is a quick and reliable method for preventing the contamination of the bronchoscope with mycobacteria.

Bronchoscopy↗

Factitious methemoglobinemia caused by hyperlipemia.

Hyperlipemia in an acyanotic patient with diabetic ketoacidosis, alcoholism, and pancreatitis produced a falsely elevated concentration of methemoglobin (19 percent) and a lower-than-expected oxygen saturation measured with an automated spectrophotometer (IL-282 CO-Oximeter). In addition, there was a "normal" hemoglobin level despite a low hematocrit reading. In vitro studies showed that hyperlipemia corresponding to triglyceride levels of 500 mg/100 ml and greater produced erroneously high values for methemoglobin and total hemoglobin and "negative" values for carboxyhemoglobin. These abnormalities disappeared when the excessive lipids were removed by washing the erythrocytes in physiologic saline solution.

Adult↗

A demand valve conserves oxygen in subjects with chronic obstructive pulmonary disease.

Demand valves conserve oxygen by limiting delivery to the inspiratory phase of respiration and reducing the waste which occurs during expiration with conventional, constant flow therapy. However, arterial oxygen tensions (PaO2) achieved in past evaluations were frequently higher than recommended for treating chronic hypoxemia. We wondered if excessive amounts of oxygen were used which would exaggerate waste with conventional therapy, and, in turn, apparent savings with demand valves. Oxygen savings were evaluated with a demand valve in ten stable COPD patients who had recommended levels of PaO2 (55 to 65 mm Hg, SaO2 90 percent to 92 percent). The valve reduced oxygen use significantly compared to conventional therapy (average savings 28 percent, range 14 percent to 49 percent). The greatest savings were found in subjects who used the highest conventional flows.

Aged↗

Spirometry: what paper speed?

Controversy still exists regarding the paper speed necessary for accurate measurements from records of maneuvers for forced vital capacity. Twenty-four spirometric wave forms of known characteristics were plotted by a computer at 1, 2, and 3 cm/sec and were measured in random order by 12 experienced readers. We found that all readers made a surprisingly large number of major errors. The speed of the paper was found to be an important determinant for accurately measuring the forced expiratory volume in one second and the mean forced expiratory flow during the middle half of the forced vital capacity. A minimum paper speed of at least 3 cm/sec is important if spirograms are to be accurately measured by hand. Human errors in measurement may be minimized by obtaining results from at least three acceptable curves, by making duplicate reading of curves, and by making use of validated computerized measurement systems.

Forced Expiratory Volume↗

Calibration and quality control of spirometer systems.

Spirometry is widely performed by a variety of health professionals in settings outside the traditional pulmonary function laboratory. It is important to very that test results are accurate, because they are used to establish diagnoses and guide therapy. A quality-control program will help verify the accuracy of testing procedures and must be developed based on equipment, personnel, and test application. Calibration is part of quality control and its meaning has evolved to include limited performance-testing. Large syringes and recently available flow calibrators allow determination of spirometer accuracy and make calibration rapid and convenient. They have the additional advantage of being portable and thus can accompany the spirometer on field trips. Calibration techniques may help in other aspects of quality control, such as test methodology and monitoring technician proficiency. Technicians are often evaluated on the ability to prepare, calibrate, and troubleshoot equipment, gain patient cooperation, determine the adequacy of effort, and calculate spirometry results. Calibration techniques may help in many aspects of this evaluation. Finally, advanced techniques may be used to study the methods used in performing clinical spirometry.

Calibration↗

A portable volume/flow calibrating syringe.

Two samples of a manual 3 L calibrating syringe which displays an electronically calculated FEF25-75% were evaluated to determine its suitability as a flow calibrator were evaluated. Room air was discharged into a manual spirometer system known to be accurate. The calibrator-determined values correlated very closely with the spirometer values over an FEF25-75% range of 0.4 to 9 L/sec. The differences between calibrator and spirometer FEF25-75% values were small (mean +/- 1 percent, greatest 3.7 percent) and of little importance clinically. This portable, simple to operate calibrating syringe provides accurate FEF25-75% and volume values. By adding flow calibrating capability to a recommended standard volume calibrating syringe, it will facilitate the routine calibration of spirometers in the laboratory and in the field. Since it uses displaced air, it can be used at altitude and with flow measuring instruments without the correction required for calibrators using CO2 cartridges.

Calibration↗

Venous thromboembolism in decompensated chronic obstructive pulmonary disease. A prospective study.

Largely on the basis of postmortem studies, pulmonary emboli have been implicated as an etiologic factor in the acute and chronic respiratory failure of chronic obstructive pulmonary disease (COPD). The diagnosis of pulmonary embolism clinically or by tests directed at the lungs (except pulmonary angiography) is likely to be inaccurate in the presence of COPD because of the underlying abnormalities. We reasoned that by directing tests at the lower extremities to determine the presence or absence of deep venous thrombosis (DVT), we might obtain an accurate reflection of the presence of pulmonary emboli (PE), since virtually all PE are believed to arise in those deep veins. Accordingly, in a group of 45 patients with decompensated COPD, we performed ascending contrast venography (12 patients), 125I-labeled fibrinogen scanning (6 patients), or both (27 patients). Only 2 patients had proximal DVT, which was probably present on admission (4.4%). Two other patients developed DVT (limited to the calf) while hospitalized, (overall incidence of 8.9%). Another patient developed superficial thrombophlebitis during the study but before venography. Noninvasive tests for DVT (Doppler ultrasound and impedance plethysmography) were performed in 40 subjects. A negative result had a high predictive value (94% for each), but contrary to findings in other settings, a positive test had a poor predictive value (Doppler = 33%, IPG = 25%).

Aged↗

Respiratory disease in Utah coal miners.

Two hundred forty-two Utah underground coal miners volunteered to participate in a respiratory disease study. They were an older group (mean, 56 years of age) and had spent a mean of 29 years in the coal-mining industry. The prevalence of chronic bronchitis was 57%, and that of coal worker's pneumoconiosis, 25%; only one worker had progressive massive fibrosis. Significant impairment of pulmonary function was found among those with a history of cigarette smoking. Chronic bronchitis or coal worker's penumoconiosis among nonsmokers did not impair pulmonary function. There was a significant association among the nonsmokers between increasing exposure to coal dust and coal worker's pneumoconiosis, but not for changes in pulmonary function. Coal mine dust had a significant influence in causing the symptom complex of chronic cough and sputum production, and coal worker's pneumoconiosis.

Bronchitis↗