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Biomedical subjects

J Wessel

Publications and source records attributed to J Wessel.

At least 55 records · Page 3Linked to original sources
PubMed1988

Eccentric and concentric torque and power of the knee extensors of females.

The purpose of this study was to compare differences in eccentric and concentric peak torque and power measurements of knee extensors at different velocities. The subjects included 21 females between the ages of 19 and 28, who had no history of knee pain or abnormality. Eccentric and concentric contractions of the knee extensors of the dominant leg of each subject were tested on an isokinetic dynameter at 60 degrees/s, 120 degrees/s and 180 degrees/s. Eccentric peak torque was greater than concentric at each of the three velocities tested, whereas eccentric power was significantly greater only at the two higher velocities. The lack of change in concentric peak torque between 120 degrees/s and 180 degrees/s contrasted with results of other studies, probably owing to methodological differences. Eccentric torque increased from 60 degrees/s to 120 degrees/s, but decreased again at the highest velocity. Both concentric and eccentric power increased with velocity.

Adult↗
PubMed1987

[Ovarian function and recurrence in adjuvant chemotherapy of breast cancer].

The present paper reports the results of a prospective study of the influence of adjuvant chemotherapy (1) on ovarian function and (2) on recurrence and the patient's endocrine function status. Observation criteria were the endocrine status before, during and after chemotherapy. The follow-up period ranged from 12 to 78 months. The patient population comprised 80 women, of whom 39 were treated with AC and 41 with CMF. Of the 80 women, 56 (70.0%) had hypergonadotropic function at the end of treatment; 31 of these had been treated with AC and 25 with CMF. Significantly more women (p less than 0.1) who had undergone AC therapy were hypergonadotropic than among those treated with CMF; 28 of the patients had recurrences during the follow-up period. Among women with undisturbed ovarian function under chemotherapy (eugonadotropinemia), recurrences occurred more frequently (50.0%) than among chemically castrated patients (28.6%). This effect was especially apparent among patients in the AC group with positive receptor status and chemotherapeutically induced ovarian suppression. CMF therapy produced no difference between eugonadotropic and hypergonadotropic patients with regard to frequency of recurrences, not even when there was a correlation with their receptor status.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Experiences with intravenous sulprostone administration in massive postpartal hemorrhage].

Forty-three patients at the University Gynecology Clinic in Charlottenburg were given the prostaglandin E2 derivative sulprostone for severe postpartal hemorrhage. It was administered intravenously in a dose of 1.7 mcg/min (100 mcg/100 ml/h), with short-term increases to three times this amount in isolated cases. The drug proved highly efficacious (rapid onset and lasting effect). In 80% of the cases there were no side effects. Rises in body temperature occurred in six patients and in one patient a venous irritation developed in the arm into which the drug was infused. An RDS occurred, though it was considered that there was not necessarily a causal connection between this and the sulprostone infusion. In the authors' experience this drug has an established place in the treatment of atonic postpartal hemorrhage emergencies.

Adult↗
PubMed1986

[Circumstances at the time of death in drug fatalities].

The circumstances in drug-related deaths were investigated in this study. The basic client sample was composed of 743 drug addicts of the opiate type who had been admitted into the institute's drug-free outpatient program from 1969 to 1982. In this program, 91 clients died during the observation period. In order to be able to judge the various backgrounds adequately, a multiply subdivided classification system was developed for the death cases. Each case was recorded in three main categories: manner of death, cause of death, and phase of addiction. This was a more elaborate procedure than those commonly used since, in general, such death cases are only subdivided into a few groups that differ little from one another. Two manners of death predominated in this sample: accidents caused by poison (62%) and suicide (25%). Within in the various causes of death, poison cases prevailed (80%) and opiate intoxication (single or combined) was predominant (60%). Concerning the phase of addiction two phases were distinguished: the actual drug addiction phase (65%) and the intramural stay in prison or a hospital (25%). There were no significant sex-related differences. Various combinations regarding the mechanism of lethal opiate intoxication of drug addicts were scrutinized, concentrating on three approaches: the lack of opiate tolerance after periods of abstinence, the synergistic effect of simultaneously taking other CNS-depressant drugs, and differences in concentration in the heroin used. Our conclusions are given from the point of view of adequate counseling for drug addicts.

Accidents↗
PubMed1986

Linear growth measurement: a comparison of single arm-lengths and arm-span.

An investigation was done to determine whether the arm-lengths of 44 children with myelomeningocele differed from those of 96 control children; whether the level of the meningocele lesion has any effect on arm-length; and to compare the relationship between arm-length and both stature and age. Mean total arm-lengths did not differ significantly between the two groups of children. However, the mean arm-spans of children with high myelomeningocele lesions differed significantly from those of control children. Within the myelomeningocele group, the height of the lesion had no significant effect on any of the arm-length variables. Very high positive correlations were found between upper-arm and total arm-lengths and stature, and between arm-span and stature in the control children. These results suggest that arm-length may be used as an alternative measure of linear growth in children, and that a single arm-length will be the most accurate indicator of growth of children with myelomeningocele.

Arm↗
PubMed1984

[Risks and perspectives of drug dependence. Catamnestic results in 100 opiate addicts during the access years 1969-1974].

The further development of 100 young drug addicts of the opiate type (72 males, 28 females) who had been medically assessed by court or police order between 1969 and 1974 was evaluated over 10 to 15 years. Until the end of 1983 20 clients had died, 14 males and 6 females. The state of the survivors was separated into 5 categories according to drug dependency, rate of delinquency and assurance of income. 39 clients were free from injectable drugs. The abstinence rate was equal in males and females. The major part of these abstinent clients was fully rehabilitated, drug-independent for years, not delinquent and integrated into work. A minor part depended on external help. Three clients were not able to earn a living. Half of the 80 survivors had to be considered at risk. International comparison shows that the increased mortality among opiate addicts is only slightly different among western industrial nations. Perspectives of survivors are also similar. Despite different treatment and intervention strategies the abstinence ratio approaches 40% after the 30th year of life with an increasing tendency with increase of age. As the now already older clients usually decline in-patient care, however accept out-patient help promoting rehabilitation successfully ("path of rehabilitation"), promotion of ambulatory care decisively involving doctors is urgently required.

Adolescent↗
PubMed1983

[Survival rate of drug addicts. Longitudinal analysis of 530 outpatient clients for the admissions years 1969 to 1977].

The mortality amongst 530 out-patient drug-addicts, dependent mainly on opiates and being first registered between 1969 and 1977, was analysed. This grand total (27% females, median age 19 years, 73% males, median age 20 years) was subdivided into three groups with variable observation follow-up according to the time-shift of consumed main drugs. Until the demarcation day 31 December 1982 81 clients (15%) died. Mortality rates were determined according to the death cases for the three groups. In comparison with the mortality of the age-matched whole population male heroin addicts had a twelve-fold and females a 29-fold death rate. Survival curves of all three groups showed a rather linear course indicating a surprisingly long period of danger. For optimisation of advice methods and for treatment of drug-addicts long-term analyses of larger unselected groups involving further parameters are required.

Adolescent↗
PubMed1980

Failure of naloxone to alter exercise-induced growth hormone and prolactin release in normal men.

Growth hormone and prolactin levels during standardized exercise tests were measured in ten normal male volunteers, with and without previous intravenous administration of 4 mg naloxone. No significant influence of naloxone on hormone release could be observed. The lack of effect indicates that an opioid pathway is not involved in exercise-induced growth hormone and prolactin release in humans, in contrast to that in rats.

Adult↗
PubMedDate not supplied

[Projective identification and denial of pregnancy--considerations of the reasons and background of unrecognized pregnancy also undiagnosed by a physician].

BACKGROUND: In denial of pregnancy, the pregnant woman does not consciously perceive the pregnancy and, in extreme cases, awareness occurs only during delivery. The attending physicians also often fail to recognize the pregnancy, even though the somatic complaints leading to consultation with a physician are typically pregnancy associated. This "iatrogenic participation" was described in the earliest historical publications. Different theories are presented in this paper to elaborate this phenomenon. Elementary deficiencies in perception or incompetence do not explain most cases. PATIENTS AND METHODS: Twenty five women with denial of pregnancy, interviews PSYCHODYNAMIC EXPLANATIONS: Based on the deep-rooted subjective attitude of not being pregnant, the pregnant woman is able to include family, friends, and associates into the denial of pregnancy mindset. In a similar way, she is able to influence her doctor. The woman's autosuggestive wishful notions of not being pregnant receive suggestive confirmation by the physician's misdiagnosis and lead to a continuing denial of pregnancy. PROJECTIVE IDENTIFICATION: In 1946, M. Klein introduced this term to describe a certain defense mechanism relating to fantasies and accompanying object relationships. The self initially successfully disposes of unwanted aspects, splits them off, and transfers them to another person, to finally reclaim them in a modified form. Certain elements of this psychoanalytical concept can characterize the interaction between physician and pregnant woman, which, in the case of denied pregnancies, does not lead to a diagnosis of pregnancy. Through projection, the pregnant woman is capable of manipulating the physician so that he perceives her, according to her wishes, as not being pregnant and misdiagnoses her correspondingly as "service in return". Opportunities for more mature handling of the denied content in terms of psychological development through accurate diagnosis of the pregnancy are indicated.

Adolescent↗