PubMed Health⌕ Search

Biomedical subjects

J Zattoni

Publications and source records attributed to J Zattoni.

At least 19 recordsLinked to original sources
PubMed1999

[Comparison of manual infusion of propofol and target-controlled infusion: effectiveness, safety and acceptability].

BACKGROUND: Diprifusor TCI is a newly developed target-controlled system for the infusion of propofol. Purpose of this study is to evaluate the acceptability, efficacy and safety of Diprifusor TCI in comparison with the manually controlled technique. METHODS: This multicentre, randomised, parallel group study was carried out in 160 patients undergoing surgical procedures of 10 min to 4 h duration in 8 centres. In each centre 20 male or female patients, aged > or = 18 years, ASA I-III were randomised to treatment with either Diprifusor TCI (TCI group--80 patients) or manually controlled infusion (MI group--80 patients). Assessments included hemodynamics; adverse events, including accidents, actual or possible; recovery times; anesthetist ratings of quality of induction and maintenance, and of ease of control and use of technique. Ratings were summed up in a global quality score (study end-point). RESULTS: Induction doses were significantly lower (median values 1.4 vs 1.9 mg/kg) and maintenance infusion rate significantly higher (median values 10.2 vs 8.8 mg/kg/h) in the TCI group; anesthetists ratings obtained maximum scores in most patients of either group, but more frequently in the TCI group, with significant differences for ease of control (good 91.2% TCI vs 74.7% IM; adequate 8.8 vs 21.5%; poor 0 vs 3.8%), and of use of technique (good 91.2% TCI vs 60.8% IM; adequate 8.8 vs 39.2%); the global quality score showed a significant advantage for the TCI system (median value 12 vs 11). CONCLUSIONS: The TCI technique is effective and safe, and has a better acceptability than the manually controlled infusion technique.

Adolescent↗
PubMed1989

[Evaluation of 2 modalities of use of propofol in cerebral angiography].

Fifty eight adult patients suffering from different intracranial lesions and scheduled for cerebral angiography were given propofol. In the first group (38 patients) brief periods of anaesthesia were induced and reinduced by means of 1.5 mg/kg of propofol iv and sometimes extended with boluses of 25-50 mg of this anesthetic. The patients were premedicated with 0.5 mg atropine im 30-40 min before the induction. Fentanyl, droperidol and diazepam in various combinations and doses were injected, im together with the atropine and iv 1-2 min before the induction, to obtain long-lasting sedations. In the second group (20 patients) the induction of the anaesthesia started 20-35 min after 0.5 mg of atropine im and 1 min after 0.1 mg of fentanyl iv. The induction was based on a bolus of 2.5 mg/kg of propofol and it was followed by suxamethonium, tracheal intubation and mechanical ventilation with N2O 70% in O2. An adequate depth of anaesthesia was maintained with supplemental doses of 50 mg of propofol, frequently associated with 25 mg of suxamethonium. Both methods proved to be reliable and safe. Nevertheless, the second method provided a better stability as far as a number of physiologic variables is concerned.

Adult↗
PubMed1987

Subcortical and cortical responses following infraorbital nerve stimulation in man.

Scalp responses following stimulation of the infraorbital nerve have been recorded in awake and anaesthetized subjects from non-cephalic (NCR) and vertex (VR) reference derivations. In awake subjects, after 3 very early potentials (W1, W2 and W3), 4 small components (P4, N5, P6 and N7) with widespread distribution have been constantly recorded from NCR derivations. Sometimes a further component, named N10, could be recorded in VR derivations on the scalp contralateral to the stimulus in the absence of earlier events. Large and inconstant waves were recorded following N7 in NCR and N10 in VR derivations. The muscular origin of these waves was demonstrated by simultaneous records taken from scalp and muscles. Records from NCR derivations in anaesthetized subjects showed that wave N7 was followed by a further event (N10) localized on the scalp contralateral to the stimulus and by a few slow waves. Wave N10 could also be recorded, in the absence of earlier events, from the VR derivation contralateral to the stimulus. All the responses recorded in these patients could be considered of neurogenic origin because curarization abolished any reflex activation of muscles. All the waves following W3 are of postsynaptic nature and, on the basis of their distribution and latency, we suggest that P4, N5, P6, N7 and N10 have their respective origins in the trigeminal nucleus, trigeminal lemniscus, thalamus, thalamic radiation and cortical projection of the stimulated area. It was also demonstrated that stimulation of lips and gums fails to evoke any neural event recordable from the scalp.

Anesthesia↗
PubMed1981

Electromanometric confirmation of needle position in haemopericardium with severe tamponade.

Simultaneous recording of the electrocardiogram and of the pressure transmitted through the drainage needle in patients with haemopericardium provided confirmation that the needle tip was in the pericardial cavity. Proper position was indicated by a positive pressure wave beginning before the QRS complex, reaching its maximum value in the first part of the ST segment and ending with the T wave. In contrast, ventricular penetration was signalled by a positive pressure wave beginning in the first part of the QRS complex, reaching its maximum during the T wave and ending between the T and P waves.

Animals↗
PubMed1981

[Contamination of the operating room by anesthetic gases and vapors. II. Gas chromatographic analysis of nitrous oxide].

The contamination by nitrous oxide of an operating room atmosphere was studied in a number of experiments, in the absence of personnel and using a gaschromatographic method. The evacuating device of the anesthesia machine proved to be ineffective to overcome the hazard of leaks in the breathing system, whereas the air conditioning flow rates (12 outside air changes per hour) minimized waste anesthetic gas concentrations.

Air Pollution↗