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Biomedical subjects

J Zattoni

Publications and source records attributed to J Zattoni.

At least 37 records · Page 2Linked to original sources
PubMed1980

Effect of single oral dose of phenobarbitone on lymphocyte blastogenic response in man.

A single oral dose of phenobarbitone 1.5 mg kg-1 was given to 18 normal subjects to evaluate the effects on lymphocyte function. Serum barbiturate concentrations and lymphocyte blastogenic response to three mitogens (PHA, Con A, PWM) were tested before and at 2, 12 and 36 h after drug administration. A serum barbiturate plateau of about 2 microgram ml-1 was maintained from 2 to 36 h. Lymphocyte blastogenesis was reduced with barbiturate compared with controls. However, the reduction was significant only at 36 h (P < 0.01).

Adult↗
PubMed1980

[Effects of the intravenous infusion of althesin on intracranial pressure and related functions].

30-60 min after the i.m. administration of 0.5 mg atropine sulphate, 9 adult conscious neurosurgical patients on spontaneous ventilation were given a total of 12 i.v. infusions of Althesin at a rate of 0,25-0,60 ml/kg/h able to induce stable clinical and EEG levels of anaesthesia. PICm, PAm and PVCm respectively decreased in all, in ten and in six administrations. The PAm decreased below 60 mmHg in only one case, in another there was no change and in another still it increased in a stable manner. In all cases PICm, PAm and PVCm decreased by a mean of 3.88 +/- 1.22 (P < 0,05), 20,76 +/- 17,44 (P < 0,05) and 0,90 +/- 1,50 mmHg. The paCO2 generally increased and, in only one case, did it induce an intracranial hypertensive reaction; the paO2 was frequently reduced. The interruption in the infusion was followed by the regression of all effects. This appened for the PICm and PAm without dangerous rebound effects. The clinical use of Althesin in neurosurgical patients is discussed with regards to problems of anaesthesia and intensive care.

Adult↗
PubMed1980

[Aspects of the mechanism of the intracranial hypotensive effect of althesin in man].

40-50 microliters/kg of Althesin were rapidly injected i.v. into 8 conscious neurosurgical patients on spontaneous ventilation (30-40 minutes after 0,5 mg atropine sulphate i.m.) for a total of 11 administrations. Electroencephalogram (EEG), intracranial pressure (PIC), systemic arterial blood pressure (PA) and central venous pressure (PVC) were continuously and simultaneously recorded. In four patients paCO2 was monitored. Slowing of EEG (accepted as an index of the brain metabolic depression) and lowering of the PIC occurred at the same time (P less than or equal to 0,001) and preceded the decrease in PA (P < 0,05) and in PVC (P < 0,05). These pressure changes were associated with both increases and decreases in paCO2. The data agrees with the hypothesis that the intracranial hypotensive effect of Althesin can be due to the induced metabolic brain depression through the secondary autoregulation of the cerebral blood flow (FEC).

Alfaxalone Alfadolone Mixture↗
PubMed1980

[Effects of an intravenous bolus of althesin on intracranial pressure and related functions].

30-40 min after i.m. administration of 0.5 mg atropine sulphate, 8 adult conscious neurosurgical patients on spontaneous ventilation were given a total of 10 rapid i.v. injections of Althesin at a dosage of 40-50 (45.5 +/- 4.33 as a mean) microliter/kg. Method was able to induce clinical and EEG signs of deep anaesthesia. PICm and PAm decreased in all cases by 6.82 +/- 3.91 (P < 0,05) and 20.18 +/- 9.30 mmHg respectively; PVCm decreased in only half of the cases. The intracranial hypotensive effect was positively correlated to the basal PICm (P < 0.05) and resulted proportionately more marked in cases with greater signs of EEG depression. The PAm never decreased below 60 mmHg. The paCO2 was generally increased and the paO2 was always decreased. The intracranial hypotensive effects regressed 12-23 min after the injection without dangerous rebound effects; recovery of the PAm was slower. The use of Althesin in the anaesthesia and in the intensive care of neurosurgical patients is discussed.

Adult↗
PubMed1980

[Changes in intraocular pressure in anesthesia induced with althesin and maintained with methoxyflurane].

Intraocular pressure and arterial blood pressure were studied in 27 patients undergoing anaesthesia induced by 0,6-1 mg/kg of Althesin iv and maintained by methoxyflurane-N2O-O2 on spontaneous ventilation. All patients were scheduled to undergo various types of eye surgery, including open-eye surgery. Patients with glaucoma and cataract were administered 20% mannitol two hours prior to surgery. In all cases premedication was based on meperidine, promethazine and atropine sulphate im. During the entire period of anaesthesia the intraocular pressure and, generally, arterial blood pressure appeared to be lowered.

Adolescent↗
PubMed1979

[Contamination of the operating room with anesthetic gases and vapors. Analytical methods].

An approach for the measurement of the contamination of the operating room air is presented. The measurements were performed in three operating rooms used for general surgery, partly in model experiments and partly while anesthesia was in progress. During anesthesia, the measurements were taken when oxygen 3 l/min containing ethrane 1.0--1.5% was passed into a semi-closed circle and the exhaled gas vented directly to the environmental air with no scavenging system in use. The daily exposure of operating room personnel was determined by adsorption of ethrane on glass tubes containing activated charcoal. The ethrane was subsequently desorbed in toluol and quantified by gas chromatography. The concentration of contaminant was found to be significantly greater in the anesthesiologist's position than in the areas of surgeon and circulating nurse. Some pitfalls in sampling, standardization, and analysis are indicated. Attention is drawn to the numerous factors influencing the extent of contamination.

Air Pollution↗
PubMed1978

Effect of capsule colour and order of administration of hypnotic treatments.

Ninety-six hospitalized insomniac patients were asked to compare by a daily questionnaire the effect on sleep of the colour of the capsules and the order of administration of two treatments--heptabarbital and placebo. A balanced incomplete-block design was used; sleep onset time and sleep duration time were the main criteria of assessment. There was a significant interaction of colour and order of administration with sex. The placebo response was positive in 36% of instances.

Barbiturates↗
PubMed1978

Propranolol in neurosurgical patients with sinus tachycardia. Cardiovascular effects and mode of use.

Cardiac rate (CR) and systolic arterial blood pressure (ABP) response to the intravenous injection of one, two, or three mg propranolol were recorded in 77 patients with traumatic, neoplastic, or haemorrhagic intracranial lesions and sinus tachycardia. In most patients tachycardia occurred with no cause except the intracranial lesion; in the other patients induction of general anaesthesia or surgical procedures on the brain appeared to have an initiating role. A central imbalance, with increased sympathetic cardiotropic influences is suggested and discussed. (I) First administrations of propranolol always reduced CR but had different effects on ABP from case to case; in all the patients 2.05 +/- 0.84 mg of drug lowered CR by 28 +/- 14/min (P less than 0.01), and ABP by 4.7 +/- 11 torr. CR decrease and ABP changes were without relation to the injected dose. Previous digitalization (desacetyllanatoside C) did not modify CR response to propranolol but reduced (P less than 0.05) its arterial hypotensive action. Positive correlations were found between basal CR and CR decrease (P less than 0.01), basal CR and ABP changes (P less than 0.01), CR decrease and ABP changes (P less than 0.05). Halothane appeared to potentiate CR response (P less than 0.01). (II) CR effect was less when the same dose of propranolol was repeated within 90 min (P less than or equal to 0.05). Usefulness and the mode of use of propranolol were critically evaluated.

Adolescent↗