Towards a DNA-like duplex without hydrogen-bonded base pairs.
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Base Pairing↗
Biomedical subjects
Jürg Hunziker
Publications and source records attributed to Jürg Hunziker.
Towards a DNA-like duplex without hydrogen bonds.
The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the base pair P-F5 promotes strong intramolecular stacking interactions in DNA duplexes. The more natural base pairs are replaced by this novel pair the higher the thermodynamic stability of the resulting duplex if they are arranged in an alternating fashion.
Calorimetry↗