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Towards a DNA-like duplex without hydrogen bonds.

Gérald Mathis·Rolf Schütz·Jürg Hunziker
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Abstract

The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the base pair P-F5 promotes strong intramolecular stacking interactions in DNA duplexes. The more natural base pairs are replaced by this novel pair the higher the thermodynamic stability of the resulting duplex if they are arranged in an alternating fashion.

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CalorimetryDNAHydrogen BondingNucleic Acid ConformationNucleic Acid DenaturationOligodeoxyribonucleotidesThermodynamicsJournal Article

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Gérald Mathis, Rolf Schütz, Jürg Hunziker. Towards a DNA-like duplex without hydrogen bonds.. https://doi.org/10.1081/ncn-120022831

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