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Biomedical subjects

Jacek Pajak

Publications and source records attributed to Jacek Pajak.

At least 19 recordsLinked to original sources

Histopathological diagnosis of microscopic colitis.

A typical symptom of microscopic colitis (MC) is chronic watery diarrhea with normal endoscopic findings and characteristic inflammatory changes in histopathology. Treatment of the disease is mainly empiric. MC has two main subtypes: lymphocytic colitis and collagenous colitis. There are also untypical histopathological forms of MC: MC with giant cells, MC not otherwise specified (NOS) and cryptal lymphocytic coloproctitis. Some other histopathological changes in MC have been observed, especially Paneth cell hyperplasia or epithelial degeneration. Eosinophilic colitis, acute colitis, amyloidosis, ulcerative colitis and Crohn's disease should be taken into consideration in differential diagnosis. The most reliable biopsy material for histopathological examination are samples obtained from transverse colon. Some studies proved that treatment of MC makes it possible to reduce not only clinical, but also histopathological, manifestations.

Colitis, Collagenous↗

Aneurysmal bone cyst of the orbit.

We report the case of an aneurysmal bone cyst of the left orbital roof in a 12-year-old boy who presented proptosis of the left eye and painless swelling of the left orbital rim. A 3-cm-large tumor developed in less than 3 months, with first visible signs about 2 months after a minor head injury. Radiologically, the lesion was osteolytic and multicystic. The cyst, filled with hematic fluid, was surgically removed via left frontal craniotomy and a simple curettage with high-speed bur. The patient recovered well and has been in good health throughout 14 months of follow-up.

Bone Cysts, Aneurysmal↗

Kikuchi-Fujimoto disease: a case report.

Kikuchi-Fujimoto disease is a rare benign cervical lymphadenopathy, which often affects young adult women. Its etiology and pathogenesis are unknown. We present the case of Kikuchi-Fujimoto disease in the Polish population and analyse the difficulties in differentiating this disease from the systemic lupus erythematosus.

Anti-Infective Agents↗

[Sarcoidosis of parotid glands. A case report].

Despite much progress made in terms of understanding sarcoidosis, it still remains an unknown disease entity. The authors present the basic diagnostic measures clinical picture as well as treatment of patients with sarcoidosis. The study presents a case of a 38-year-old man with sarcoidosis of parotid glands treated with encortone which was followed by remission of the disease.

Adult↗

[Cemento-ossifying fibroma--case report and review of the literature].

Authors report two cases of benign, osteogenic neoplasms of the maxilla in children which defined as cemento-ossifying fibroma and juvenile cemento-ossifying fibroma. Difficulty in diagnosis of the tumor is indicated. The importance of clinical data as well as radiology and histopathology examination for a proper diagnosis is indicated. Review of literature is presented.

Cementoma↗

[Primary cardiac malignant fibrous histiocytoma in 47-year-old woman].

A case of pleomorphic malignant fibrous histiocytoma of the right atrium and right ventricle is presented. Primary cardiac malignant fibrous histiocytoma (MFH) is extremely rare and its etiology and clinical course are not precisely known. We treated a 47-year-old female patient with persistent fever and cough, shortness of breath and anasarca. The patient died after eight months with symptoms of cardiac shock. Autopsy revealed a big soft yellow tumor in the right heart. Microscopically, atypical fibroblast-like cells, pleomorphic and multinucleated giant tumor cells with eosinophilic cytoplasm were observed within the myxoid and fibrous stroma. Immunohistochemically, tumor cells were positive for alfa-1-antitrypsin and partially positive for CD68 and vimentin. According to histopathologic and immunohistochemical features we diagnosed pleomorphic MFH.

Female↗

[Distant metastases to the parotid gland--review of the literature and report of own two cases].

Metastatic tumors to the parotid gland are very uncommon and it accounts for 8% of all cancers of parotid gland. The parotid gland and its lymph nodes are possible sites of metastases from head and neck cancers. However, metastasis from distant primary neoplasm below clavicle is possible, too. The authors presented the two cases of distant metastases to the parotid gland. The women with breast cancer and metastases to the parotid gland 11 years after surgery, radio- and chemotherapy of breast cancer. She died 7 months after parotid surgery of systemically advanced disease. The man with metastasis of malignant melanoma of unknown primary site. He underwent total parotid surgery with the tumor and lymph nodes. He died 7 months after surgery. In spite of intensive exam the primary location of the melanoma was unknown. The authors described pathophysiology of distant metastases to the parotid gland with special attention to possibilities of treatment and survival.

Adult↗

[Osseous metaplasia in rectal cancer in a 69-year-old man].

The first case of osseous metaplasia in rectal cancer is described. The authors present the diagnostic evaluation based on the transrectal ultrasound examination, determination of neoplastic markers, pathological examination, treatment, and follow-up in a 69-year-old man.

Aged↗

[Primary extranodal non-Hodgkin's malignant orbital lymphomas treated surgically in ENT Department of Medical Academy of Silesia in Katowice in the years 1996-2001].

The authors presented 7 cases of primary extranodal non-l-odgkin's malignant orbital lymphomas in patients treated surgically in the ENT Department of the Medical University of Silesia in the years 1996-2001. In the course of the diagnostic process we examined the patients carefully to be sure that the cancer had not disseminated. We used some imaging techniques such as: ultrasonography (USG), computer tomography (CT) and magnetic resonance imaging (MRI). We also used the needle aspiration biopsy, as an additional examination. However the material was no significant in the most cases and we were unable to make a definitive diagnosis on the basis of this method alone. After prior examinations we performed the radical operations and removed the tumors. In each case the postoperative material was examined using histopatological and immunohistochemical methods. Afterwards the pathomorphological diagnosis was made by the specialists. Next the patients were observed and treated in the Haematological and Radiotherapy Departments.

Academic Medical Centers↗

[A case of aggressive systemic mastocytosis].

The study presents a case of systemic mastocytosis, discovered in 64 years old male, after two years of persistent fever and chest pain with dyspnea. The authors describe differential diagnostics including imaging and laboratory procedures. Presented material contains pictures of histopathological sections and biopsies. Attention was drawn to the importance of histopathology and immunohistochemical assays in differential diagnostics of uncertain cases.

Chest Pain↗

[Oral cavity infantile myofibromatosis in older children].

Infantile myofibromatosis (IM) is a rare condition that usually occurs in newborns and young children under the age of 2 years. Three cases of IM in older children are presented. Clinical, morphological and immunohistochemical features of the lesions are described. The lesions appeared as solitary, fast growing oral tumors. Infantile myofibromatosis rises the oncological concern and requires differentiation with benign and malignant soft tissue tumors as well as juvenile and infantile fibromatosis.

Child↗

[Histologic and clinical assessment of primary extranodal non-Hodgkin malignant lymphomas of the head and neck region].

The authors presented 27 cases of primary extranodal non-Hodgkin's malignant lymphomas of the head and neck area in patients treated surgically in the ENT Department in the years 1996-2001. We observed tumors in the various areas: palatine tonsil, naso-pharynx, eye socket, paranasal sinuses, parapharyngeal space and lingual base. In the course of the diagnostic process we examined the patients carefully to be sure that the cancer had not disseminated. We used some imaging techniques such as: ultrasonography, CT and MRI. We also used the needle aspiration biopsy, as a additional examination. However the material was not significant in the most cases and we were unable to make a definitive diagnosis on the basis of this method alone. After prior examinations we performed the radical operations and removed the tumours. In each case the postoperative material was examined using immunohistochemical methods. Afterwards the pathomorphological diagnosis was made by the specialists. Next the patients were observed and treated in the Haematological Department and Radiotherapy Department. In all cases pathomorphological diagnosis were performed on the base of usage postoperative histochemical examinations. All treated patients were performed as diagnostic preoperative USG, CT, MRI and fine-needle biopsy aspiration exam. All patients for further treatment were observed at Haematological Department.

Adolescent↗

Mandible metastasis of hepatocellular carcinoma.

Metastases to oral cavity are very uncommon. We present a case of hepatocellular carcinoma (HCC) metastasis to the jaw. The x-ray examination and clinical picture of the lesion were not characteristic. The gingival metastasis may mimic other benign and malignant conditions which affect jaw and therefore the histopathological examination is necessary to make an ultimate diagnosis.

Adult↗

[Ebstein syndrome--various forms, clinical view and treatment results in children].

UNLABELLED: Ebstein's anomaly is an uncommon lesion of the tricuspid valve characterized by downward displacement of the tricuspid valve. The aim of the study was an analysis of the form, clinical outcome and treatment results in patients (pts) diagnosed with Ebstein anomaly. METHODS: 28 pts were analysed. Material has been divided into 3 groups, depending on clinical symptoms. The group A was formed with mild shape of the defect, group B all pts presenting significant clinical symptoms requiring treatment, and group C made of pts having severe symptoms requiring intensive treatment including surgical intervention. RESULTS: Anomaly had been detected in 13 boys and in 15 girls. Group A consisted of 6 children, including one boy diagnosed with defect prenatally. Described patient currently is followed-up in pulmonology outpatient clinic due to asthma. Other children are doing well and require no treatment. Group B was represented by 8 children requiring treatment of: sepsis, arrhythmia due to WPW syndrome and in one case ASD 2. Group C consisted of 14 patients. In 7 pts Ebstein anomaly was part of a complex congenital heart defect. In 5 cases dominating symptoms were severe heart failure with cyanosis and arrhythmia and in two cases sepsis. 10 pts had been treated surgically (7 pts had Blalock-Taussig shunt, 1 pt artificial valve replacement, 1 pt Fontan op. and 1 pt ASD 2 suture) where 8 died. The causes of death were: right ventricle failure and arrhythmia in 4, sepsis in 2, and pulmonary artery hypoplasia and metabolic acidosis also in 2 cases. CONCLUSIONS: Ebstein anomaly includes wide spectrum of anatomical and clinical findings. The most severe forms require surgical intervention, however it can be a high risk procedure.

Adolescent↗

[Infections as a preoperative problem in patients with tetralogy of Fallot (TOF) associated with complete atrioventricular canal septal defect (AVC)].

UNLABELLED: Tetralogy of Fallot (TOF) coexisting with atrioventricular canal septal defect (AVC) is a rare combination of anomalies. Additionally, in cases with concomitant Down syndrome, recurrent infections can be a serious problem in patients (pts.) waiting for cardiosurgery treatment. The purpose of the study was an analysis of types of infections and other factors complicating the preoperative period in those patients. MATERIAL AND METHODS: The study group consisted of 17 pts. with TOF and AVC aged from 1 day to 9 years (mean 9.4 month). In this group there were 11 pts. with Down syndrome. All of them were subjected to physical examinations, blood analysis, ECG, chest X-ray and echocardiographic study. Additionally, in 8 pts. we performed catheterization. The signs of different types of infection were analyzed and results were compared in two groups: with and without Down syndrome. RESULTS: The differences were observed in the frequency of recurrent or chronic infections (21 v/s 4), time of hospitalization before surgery (17 v/s 9 days), necessity (11 v/s 3) and duration of antibiotic therapy (19 v/s 7 days) in the two studied groups. Elevated body temperature of unknown etiology was noted in 8 cases with Down syndrome, compared to 1 patient without trisomy 21. Also, the children with Down syndrome had to wait 11 days longer (19 v/s 8) for discharge after operation. CONCLUSIONS: Infections in children with TOF, AVC and Down syndrome significantly complicate the natural course of this anomaly. Prolonged preoperation time is characteristic of Down syndrome pts. compared to patients without chromosomal abnormalities.

Bacterial Infections↗