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Jacek Pajak

Publications and source records attributed to Jacek Pajak.

30 records · Page 2Linked to original sources
PubMed2004

[Myoepithelial carcinoma of the parotid gland--a case report].

The case of parotid gland tumour of the carcinoma myoephitelial histological structure in 55 year old patient was described in the paper. The patient had the surgical treatment of total parotid gland removal with the function of the facial nerve preserved and a complementary radiotherapy. The attention is paid to rarity of this type of tumour and difficulties in a proper patomorphological evaluation requiring special immunohistochemical tests.

Carcinoma↗
PubMed2004

The issue of bioresorption of the Bio-Oss xenogeneic bone substitute in bone defects.

Bone grafts and bone substitute biomaterial implemented in guided tissue regeneration should undergo the process of biological decomposition in the recipient's system. The aim of this work is the presentation of current views concerning the issue of Bio-Oss bovine bone bioresorption and their juxtaposition with the results of the author's own research. The work presents histopathological and immunohistochemical tests of the xenogeneic Bio-Oss preparation from biopsies carried out 30 months after implantation. It was observed that the preparations contained correct bone neighbouring remnant particles of Bio-Oss, intratrabecular fibromatosis around the implant, abundant vascularisation, absence of osteoid and of active inflammatory process. A small number of T and B lymphocytes was detected. The results obtained in the above-described case testify to the descending character of the inflammatory infiltration 30 months after the implementation of Bio-Oss and efficient restoration of the bone. The prevalent view in literature is that Bio-Oss is resorbable biomaterial. However, there are also reports questioning this view as remnants of Bio-Oss have been detected even 44 months after implantation into the bone defect. In the author's own cases, Bio-Oss remnants could be observed 30 months after implanting. It seems that although the creation of new bone structure is indisputable, the process of biological decomposition of Bio-Oss should be described as slow bioresorption.

Biopsy↗
PubMed2003

[A case of primary non-Hodgkin brain lymphoma].

The paper presents a rare case of primary, non-Hodgkin brain lymphoma discovered in 64 years old woman. Non specific symptoms conducted to misdiagnoses of dementia and syderopenic anaemia. The proper identification has been made after 10 months by post-mortem histopathological analysis.

Brain Neoplasms↗
PubMed2003

Decreased red blood cells deformability in acute pancreatitis in the rat. Effect of tirilazad mesylate.

UNLABELLED: The ability of erythrocytes to deform is the key feature in maintain the microcirculation. Both acute pancreatitis and decrease in deformability of erythrocytes are associated with increase in lipid peroxidation as a result of excess production of free radicals. Hence the aim of this study was to investigate the red blood cell (RBC) deformability and lipid peroxidation product content within erythrocytes in acute pancreatitis in rats. MATERIAL AND METHODS: Rats with cerulein induced acute edematous pancreatitis (CR), pancreatitis induced by cerulein and water immersion stress (CR + WIS) and closed duodenal loop pancreatitis (CDL) treated by tirilazad mesylate were sacrificed in 9 th hour of the experiment. Deformability of erythrocytes has been investigated by means of shear stress diffractometry and expressed as elongation index (EI). Histological scoring and serum amylase were used as parameters of acute pancreatitis. Lipid peroxidation products have been assayed in RBC as a malonyldialdehyde. 1. There were no changes in EI of RBC during CR. 2. EI of RBC were impaired at low shear stresses (up to 3.0 Pa) but not in higher shear stresses in CR + WIS. 3. CDL are associated with decreases of elongation indexes in all shear stresses. 4. Tirilazad mesylate prevent decrease in EI of RBC in CR + WIS but not in CDL. 5. A significant increase in MDA content in RBC in CR, CR + WIS, but not in CDL as compared to control rats was observed. 6. Tirilazad mesylate has no effect on MDA content in RBC during experimental acute pancreatitis. CONCLUSIONS: 1. In experimental acute pancreatitis a decrease in erythrocyte's deformability has been observed. 2. Protective effect of tirilazad mesylate on decrease in RBC deformability in acute pancreatitis induced by cerulein and water immersion stress are not depend on inhibition of lipid peroxidation within erythrocytes.

Acute Disease↗
PubMed2002

Epidural hematomas in a child with Hutchinson-Gilford progeria syndrome.

INTRODUCTION: Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder. It is characterized by severe growth failure, premature aging, and very early atherosclerosis with coronary artery disease and cerebrovascular disease. CASE REPORT: A 10-year-old boy with HGPS was admitted to our department because of progressive deterioration after a mild head injury. The CT scans revealed epidural hematoma in posterior fossa and another one in the temporal region on the left side. On admission the child was given an estimated score of 10 on the GCS. Neurological examination revealed right hemiparesis. The boy was operated on, and both hematomas were evacuated. In a few days the neurological symptoms disappeared, and he was discharged from the hospital with only residual, minimal right hemiparesis. CONCLUSION: Intracranial pathology was certainly caused by the head trauma, but was more severe than would have been expected had the trauma been the sole cause. We suggest that progressive atherosclerosis of intracranial vessels was responsible for formation of the hematomas.

Child↗
PubMed2002

[A case of postmenopausal hyperandrogenism caused by a lipid cell tumor].

Steroid-secreting neoplasms of the ovary and adrenal gland comprise a small group of tumors. A 76-year-old woman presented hair loss, facial hirsutism associated with increased serum total testosterone level. The adrenal glands and the ovaries were normal on radiological and ultrasonographic investigation. The patient was submitted to a pelvic exploratory laparotomy. Hysterectomy and salpingo-oophorectomy were performed. A solid and circumscribed ovarian tumor of 2 cm in diameter was found. The pathological diagnosis was lipid cell tumor with stromal hyperplasia. The purpose of this report is to relate how difficult is to establish the diagnosis and the origin of the hyperandrogenism in a patient with normal image studies.

Aged↗
PubMed2002

[Early postoperative period in children with hypoplastic left heart syndrome in the comparison of classic and modified Norwood procedures].

INTRODUCTION: The Norwood operation in neonates with hypoplastic left heart syndrome is associated with very high mortality. AIM: To compare early postoperative period in children who underwent classic operation to that in patients who underwent a new modification of the Norwood procedure. METHODS: Evaluation of the early postoperative period (72 h after the operation) in patients who underwent classic operation: Group 1 (31 children) and patients in whom modified Norwood procedure was performed: Group 2 (18 children). The surgical technique of the modified Norwood procedure was presented (right ventricle- to = pulmonary artery shunt and neo-aorta reconstruction by direct anastomosis between aortic arch and main pulmonary artery). RESULTS: In Group 1 in 15 (48.4%) children circulatory collapse occurred, requiring resuscitation, which was unsuccessful in 9 (60%) cases. In Group 2 one child died and early postoperative period of the other was uneventful. The mean circulatory arrest time in deep hypothermia was significantly (p = 0.002) shorter in Group 2 (mean: 33.7 +/- 8.7 min, range 25-53 min) than in Group 2 (mean: 54.1 +/- 6.6 min, range 41-76 min) and cardiopulmonary bypass time was not significantly prolonged (Group 1: mean 70.5 +/- 24.2 min, range 48-167 min; Group 2: mean 62.5 +/- 9.6 min, 39-84 min) (p = 0.765). In Group 2 there was significantly higher diastolic pressure 4, 8, 12, 24 and 36 h after the operation (p < 0.001, p = 0.005, p = 0.037, p = 0.017, p = 0.022, respectively). CONCLUSION: The new modification of the Norwood procedure ensures stable conditions in early postoperative period. We believe that short circulatory arrest time without prolongation of cardiopulmonary bypass time and higher diastolic pressure (the location of the proximal shunt end beneath the valve of the systemic circulation) improves the function of the heart.

Heart Bypass, Left↗
PubMed2002

[Mucoepidermoid carcinoma of the larynx].

Mucoepidermoid carcinoma is classified among the salivary gland tumors and is commonly found in the parotid gland. In the larynx it is an uncommon tumor that occurs mostly in men. There have been only about 100 cases of laryngeal mucoepidermoid carcinoma reported in the literature. Three cases of mucoepidermoid carcinoma of the larynx are reported. First case--tumor T1N0 localised on the vocal cord was removed using Kleinsasser method. Second and third case--tumor T3N0 was removed by total laryngectomy. The inherent difficulties in histologic diagnosis are noted and treatment of mucoepidermoid carcinoma is discussed. The available literature is reviewed.

Carcinoma, Mucoepidermoid↗
PubMedDate not supplied

Schwannomalike mixed tumor of the parotid gland: a case report.

BACKGROUND: Schwannomalike mixed tumor is a rare benign tumor of the parotid glands. CASE: A 75-year-old woman presented with a tumor 3 cm in diameter localized in her left parotid gland. Fine needle aspiration (FNA) of the lesion revealed 2 types of cells: 1 with elongated, wavy, hyperchromatic nuclei and a scant cytoplasmic border and 1 with larger, weakly staining nuclei and more abundant cytoplasm. Morphologic examinations were performed. CONCLUSION: FNA cytology was very useful in the diagnosis of this rare tumor of the parotid gland.

Adenoma, Pleomorphic↗
PubMedDate not supplied

[Mediastinal involvement in the course of proliferative diseases in children in the materials of one institution].

UNLABELLED: The mediastinum region may be the primary or secondary localization of neoplasms. The aim of our study was the assessment of clinical symptoms, histopathology and outcome of mediastinal tumours in children. MATERIALS AND METHODS: A group of 27 children, chosen from the group of 128 patients with malignancies, which were treated in the years 2000-2004 in the Oncology and Haematology Unit of the Paediatric Department in Katowice, has been studied. In this group there were 14 boys and 13 girls at the age between 2 and 12 years. We analysed the clinical symptoms prior to the diagnosis and the duration of these symptoms, histologic type of tumours and results of treatment. RESULTS: The primary localization in the mediastinum was diagnosed in 23 patients (85,2%) among them 15 (55,5%) of these children have been diagnosed as having Hodgkin's disease, and in 8 (29,6%) non Hodgkin's lymphoproliferative disease. Four of the children (14,8%) had mediastinal secondary localization of solid tumours (2 - neuroblastoma, 1 - carcinoma suprarenalis, 1 - carcinoma epitheliale of unknown origin). The most frequent symptoms were: fever (70,3%), weakness (66,6%), cough (55,5%), madiastinalpain (33,3%). The duration of these symptoms prior to the diagnosis was between 5 days and 182 clays. CONCLUSIONS: 1. In the group of neoplasms localized in the mediastinum, lymphoproliferative diseases are the most frequently diagnosed disorders. 2. In case of fever of unclear etiology and persistent cough, it is necessary to exclude mediastinal malignancy. 3. There is a need to improve the system of oncological education for medical students and doctors.

Carcinoma↗
PubMedDate not supplied

[Orbital pseudotumour imitating a proliferative process].

INTRODUCTION: Orbital pseudotumour is a non-specific inflammatory process of the orbit of unknown origin. It is a rarely diagnosed disease particularly in children, which imitates a neoplastic process. Typical clinical picture is a tumour localized in the orbit, causing various degree of exophtalmus and a decrease of globe mobility and vision. The extent of intraorbital changes are revealed by imaging studies (USG, TK, MR). Diagnosis is based on histopathology of tumour sample. In treatment steroid therapy, radiotherapy or chemotherapy in resistant cases are used. Relapse and malignant transformation are observed. CASE REPORT: We present a case of a 5-years old girl with orbital pseudotumour. In the histopathological examination there a small lymphoid cells, immunohistochemically there is mixed lymphocytic T and B infiltration (CD 3 (+), CD 20 (+), bcl (+), CD 43 (-)). She was treated with steroid therapy, and achieved complete regression of the tumour. At present she is regularly oncologically examined because of the possibility of malignant transformation. CONCLUSIONS: 1. Orbital pseudotumour should be included in the differential diagnosis of children with an orbital tumour 2. Corticosteroids seem to be the treatment of choice in orbital pseudotumour 3. Children with orbital pseudotumour should be regularly oncologically examined because of the possibility of malignant transformation.

Child↗