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James C Perry

Publications and source records attributed to James C Perry.

8 recordsLinked to original sources
PubMed2006

Malalignment of the septum primum with abnormally positioned left atrial appendage: unusual combination in a Shone's heart.

This case discusses a Shone's variant with small left ventricle and mitral valve, bicuspid aortic valve, coarctation of the aorta, an unusual arrangement of atrial appendages, and partially anomalous pulmonary venous drainage due to a deviated atrial septum. The left atrial appendage could be directly entered from the right atrium at catheterization, but it was positioned behind the great arteries. The right atrial appendage was normal in origin and orientation. The implications of this anatomy in fetal cardiac development are reviewed.

Abnormalities, Multiple↗
PubMed2006

Proximity of coronary arteries to the atrioventricular valve annulus in young patients and implications for ablation procedures.

The distance from the endocardial surface of the atrioventricular valve annulus and adventia of the adjacent coronary artery (CA) has not been delineated and may play an important role in the risk for CA damage during catheter ablation procedures. This distance was measured in 10 normal pediatric heart specimens at 11 locations around the right and left atrioventricular grooves. The endocardium-to-CA distance varied by age and location, with the shortest distances in the region of the os of the coronary sinus and the greatest distances in the right anteroseptal area. Excluding right anteroseptal measurements, in the 5 patients <7 years of age, the endocardium-to-CA distances were <or=4 mm in 76% and <or=5 mm in 96%. Given lesion sizes during ablation procedures, these distances and their potential relation to the risk for CA damage need to be taken into account during catheter ablation procedures in young patients.

Adolescent↗
PubMed2005

Intravenous amiodarone for incessant tachyarrhythmias in children: a randomized, double-blind, antiarrhythmic drug trial.

BACKGROUND: Intravenous (IV) amiodarone has proven efficacy in adults. However, its use in children is based on limited retrospective data. METHODS AND RESULTS: A double-blind, randomized, multicenter, dose-response study of the safety and efficacy of IV amiodarone was conducted in 61 children (30 days to 14.9 years; median, 1.6 years). Children with incessant tachyarrhythmias (supraventricular arrhythmias [n=26], junctional ectopic tachycardia [JET, n=31], or ventricular arrhythmias [n=4]) were randomized to 1 of 3 dosing regimens (low, medium, or high: load plus 47-hour maintenance) with up to 5 open-label rescue doses. The primary efficacy end point was time to success. Of 229 patients screened, 61 were enrolled during 13 months by 27 of 48 centers in 7 countries. Median time to success was significantly related to dose (28.2, 2.6, and 2.1 hours for the low-, medium-, and high-dose groups, respectively; P=0.028). There was no significant association with dose for any arrhythmia subgroup, including JET, but the subgroups were too small for an accurate assessment. Adverse events (AEs) were common (87%), leading to withdrawal of 10 patients. There were 5 deaths in the 30-day follow-up period (2 possibly related to the study drug). Dose-related AEs included hypotension (36%), vomiting (20%), bradycardia (20%), atrioventricular block (15%) and nausea (10%). CONCLUSIONS: In children, the overall efficacy of IV amiodarone, as measured by time to success, was dose related but not significantly for any arrhythmia subgroup. AEs were common and appeared to be dose related. Although efficacious for critically ill patients, the dose-related risks of IV amiodarone should be taken into account when treating children with incessant arrhythmias. Prospective, placebo-controlled trials would be helpful in assessing antiarrhythmic drug efficacy in children, because their results may differ from retrospective series and adult studies.

Adolescent↗
PubMed2003

"Transseptal" technique through atrial baffles for 3-dimensional mapping and ablation of atrial tachycardia in patients with d-transposition of the great arteries.

Access to targets for radiofrequency ablation in patients with congenital heart disease may be limited by anatomy and by surgically placed obstacles. In patients with atrial switch anatomy for d-transposition of the great arteries, the critical isthmus for maintenance of intraatrial macroreentry circuits is found often on the pulmonary venous side of the atrial baffle. A retrograde approach is extremely difficult for these arrhythmias. Use of transseptal techniques for diagnostic catheterization in these patients has been reported. We report the use of a transseptal technique in two cases in conjunction with 3-dimensional electroanatomic mapping for the successful ablation of atrial reentry tachycardias in patients with Mustard and Senning anatomy.

Adolescent↗
PubMed2002

Techniques to avoid atrioventricular block during radiofrequency catheter ablation of septal tachycardia substrates in young patients.

UNLABELLED: Radiofrequency catheter ablation (RFCA) has proven safe for most young patients, but the risk of inadvertent atrioventricular (AV) block remains. The purpose of this report is to describe techniques to avoid inadvertent AV block during effective RFCA in young patients with septal tachycardia substrates. METHODS: The techniques included intubation and apnea during RFCA, coronary sinus pacing during RFCA to observe intact AV conduction during junctional ectopy, localizing the optimal His electrogram prior to RFCA, not ablating during tachycardia and titrating power output with temperature monitoring. RESULTS: In the period January 1995-June 2001, RFCA of 424 tachycardia substrates was performed. A total of 217 consecutive septal tachycardia substrates are included in this report. Apnea eliminated a mean catheter tip displacement of 5.4 +/- 2.5 mm seen during respiration. No patient experienced transient or permanent complete AV block after any of the 217 substrate ablation procedures. All of the patients had normal PR intervals following ablation without development of any degree of AV block in 194 patients at latest follow-up. RFCA success for substrates with septal accessory pathways was 87/96 (91%), permanent junctional reciprocating tachycardia (PJRT) 15/16 (94%), typical atrioventricular node reentry tachycardia (AVNRT) 82/85 (96%), atypical AVNRT 6/7 (86%) and intra-atrial reentry tachycardia (IART) 10/13 (77%). Fluoroscopy time averaged 10.8 minutes. For patients with accessory pathway, 8 (7.9%) developed a recurrence. CONCLUSION: Catheter stability is paramount to safe and effective RFCA in septal locations. Use of these techniques resulted in acceptable success rates and low recurrence rate for RFCA of septal tachycardia substrates while avoiding inadvertent AV block in these young patients.

Adolescent↗
PubMed2002

Conversion to digital technology improves efficiency in the pediatric echocardiography laboratory.

BACKGROUND: Although the videotape method (VTM) is commonly used to record and intrepret ecocardiographic images, many pediatric echocardiographers are considering acquiring to, interpreting from, and storing their images to digital disk using the single-beat digital acquisition method (SBM). The paucity of image redundancy using SBM should translate into improved laboratory efficiency compared with VTM, but hard data are lacking. The purpose of this study was to test the hypothesis that the time to acquire images to videotape using VTM and to disk using SBM would be the same for normal hearts and corresponding congenital heart diseases, but interpretation times would be shorter using SBM. METHODS: We measured the times to acquire and interpret 403 echocardiograms using standard VTM from Children's Hospital in Cincinnati, Ohio, and 352 echocardiograms acquired using SBM from Children's Hospital in San Diego, Calif. Diagnostic categories at each site included: (1) normal, (2) simple shunt or isolated valve disease, and (3) multiple-lesion disease. RESULTS: As a group, SBM echocardiograms included more hemodynamic measurements and took more time to acquire (P <.037), but less time to read (P <.001) than corresponding images acquired using VTM. Using SBM, it took more time to acquire normals and isolated valve or shunt lesions, whereas the average time to acquire multiple-lesion disease was the same using both VTM and SBM. With SBM, in contrast, interpretation times were significantly less for all corresponding diagnoses. CONCLUSION: SBM studies took longer to acquire because more hemodynamic measurements were acquired, but they were read in less time than corresponding VTM studies even though all videotapes were replayed in search fast-forward mode. Pediatric echocardiographers can increase their laboratory efficiency by converting from VTM to SBM.

Analog-Digital Conversion↗