PubMed Health⌕ Search

Biomedical subjects

John Frazer

Publications and source records attributed to John Frazer.

2 recordsLinked to original sources

Arson: a growing inferno.

In a series of 34 arsonists, our survey compares the changing trends in arson to an earlier study carried out ten years ago in the same region in the UK by Rix (1994). The survey is based on pre-trial court reports done by the second author only. Fire-setting offending was predominantly seen in the young male (18-32). Fire-setting started as early as age seven and was seen as late as 63 years of age. More than half of the subjects received some form of family support. At least one third had an ICD-10 (WHO, 1992) diagnosable mental disorder and more than half were diagnosed with a psychiatric disorder during the time of reporting. A third of the subjects had a personality disorder diagnosis prior to reporting and another third had disordered personality traits established during the time of reporting. More than half had a psychological motive. Eleven per cent started a fire for excitement with only one for revenge. A third of the subjects were first time arsonists. Sixty-five per cent of arson involved building damage and all the 34 subjects were under the influence of alcohol prior to and during the act of arson. Additionally, there was cannabis use in nearly half of the subjects. Opioids and poly substance abuse were seen in a third of subjects. With the extent of financial and social burden along with risks, attention should be focused on accessing these individuals early to preventing recidivism. More research needs to be undertaken to identify the psychological motives behind fire-setting and to look into the drugs and alcohol problems amongst the younger age groups.

Adolescent↗

Functional assays for screening GPCR targets.

G-protein-coupled receptors (GPCRs) are valuable molecular targets for drug discovery. An important aspect of the early drug discovery process is the design and implementation of high-throughput GPCR functional assays that allow the cost-effective screening of large compound libraries to identify novel drug candidates. Several functional assay kits based on fluorescence and/or chemiluminescence detection are commercially available for convenient screen development, each having advantages and disadvantages. In addition, new GPCR biosensors and high-content imaging technologies have recently been developed that hold promise for the development of functional GPCR screens in living cells.

Animals↗