Biomedical subjects

Jungyoup Han

Publications and source records attributed to Jungyoup Han.

2 recordsLinked to original sources

PubMed2006

Flexible biosensors on spirally rolled micro tube for cardiovascular in vivo monitoring.

New flexible biosensors on a spirally rolled micro tube have been designed, fabricated and characterized for microcatheter-based cardiovascular in vivo monitoring. With this new microfabrication method, sensors, wires and circuits can be fabricated first on the flexible polymer substrate (Kapton film) and then rolled spirally to make micro tubes with different diameters. This approach provides a unique method for mounting multiple sensors on both the inside and outside the tube. So, the new spirally rolled polymer tube flexibly conceives physical, biomedical and physiological microsensors, elevating most problems arisen from wiring and assembling of microsensors in conventional microcatheters. As a demonstration vehicle, we fabricated glucose biosensors on the 25 microm thick Kapton film first, then the film was spirally rolled to make a polymer micro tube with the glucose sensors on the inside wall of the tube. To verify the performance of the spirally rolled glucose biosensor, we characterized it both in a planar unrolled and rolled conditions and compared their performances. The spirally rolled glucose sensors showed good performance in the typical glucose concentration range in human blood from 60 mg/dL to 120 mg/dL with different rolled diameters at different working temperature.

Biosensing Techniques↗

PubMed2006

A disposable on-chip phosphate sensor with planar cobalt microelectrodes on polymer substrate.

Disposable microsensors on polymer substrates consisting of fully integrated on-chip planar cobalt (Co) microelectrodes, Ag/AgCl reference electrodes, and microfluidic channels have been designed, fabricated, and characterized for phosphate concentration measurement in aqueous solution. The planar Co microelectrode shows phosphate-selective potential response over the range from 10(-5) to 10(-2)M in acidic medium (pH 5.0) for both inorganic (KH(2)PO(4)) and organic (adenosine 5'-triphosphate (ATP) and adenosine 5'-diphosphates (ADP)) phosphate compounds. This microfabricated sensor also demonstrates significant reproducibility with a small repeated sensing deviation (i.e. relative standard deviation (R.S.D.)<1%) on a single chip and a small chip-to-chip deviation (i.e. R.S.D.<2.5%). Specifically, while keeping the high selectivity, sensitivity, and stability of a conventional bulk Co-wire electrode, the proposed phosphate sensor yields advantages such as ease of use, cost effectiveness, reduced analyte consumption, and ease of integrating into disposable polymer lab-on-a-chip devices. The capability to sense both inorganic and organic phosphate compounds makes this sensor applicable in diverse areas such as environmental monitoring, soil extract analysis, and clinical diagnostics.

Biosensing Techniques↗