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Biomedical subjects

K Adamovich

Publications and source records attributed to K Adamovich.

29 records · Page 2Linked to original sources
PubMed1991

Effects of NH4Cl metabolic acidosis on proximal and distal tubular sodium reabsorption in newborn infants.

The present study was undertaken to assess the influence of acute metabolic acidosis on proximal and distal tubular sodium reabsorption in a group of 7 one-week-old neonates with a mean birth weight of 2,164 g (range: 1,300-3,750 g) and a mean gestational age of 34 weeks (range: 28-40 weeks) undergoing an NH4Cl loading test. Free water clearance during water diuresis was used to estimate separately the proximal and distal sodium reabsorption. In response to NH4Cl metabolic acidosis urine flow rate (p less than 0.01) and free water clearance (p less than 0.025) increased significantly, and there was a general tendency for creatinine, osmolar and sodium clearance to increase without achieving statistical significance. The absolute amount of sodium delivered to (p less than 0.01) and reabsorbed in the distal nephron (p less than 0.01) increased significantly in spite of the constant fractional distal reabsorption. The enhanced distal sodium reabsorption during acidosis is assumed to be related to the acidosis-induced increase in aldosterone production.

Acidosis↗
PubMed1990

[Survival rate and follow up studies of very low birth weight (less than 1000 g) premature infants].

The Neonatal Intensive Care Unit (NICU) at the Department of Pediatrics, University Medical School Pécs had been established 11 years ago. 219 premature infants who weighed 1000 g or less were admitted to the NICU between Jan. 1978 and Dec. 1988. The authors analysed the hospital records of there patients and found a marked increase in survival rates during the last five year period. The data presented strongly suggest that improvement of obstetric care, development of respiratory and fluid therapy, the increasing experience of hospital staff caring for the infants are the main factors contributing to improved results. At the same time the adverse effects of transportation from the referring institution are well demonstrated. The main causes of death remained the same over the 11 years studied. The number and severity of acute and late complications decreased markedly. The intensive care of very low birth weight infants is becoming increasingly expensive. However the growing expenditures are justified by increasing life expectancy of patients and the expected better quality of life among survivors.

Follow-Up Studies↗
PubMed1990

Cytochrome oxidase deficiency affecting the structure of the myofibre and the shape of mitochondrial cristae membrane.

Cytochrome oxidase deficiency was detected in the skeletal muscle of a newborn floppy child. There was a significant decrease in the quantity of subunit 5 and 6 of cytochrome oxidase as showed in Western blot with cytochrome oxidase antibody. By contrast, the NADH: cytochrome c oxidoreductase activity was normal. Electron microscopic studies revealed serious distortion in the myofibres with broken Z-bands and disorganized fibers. The relative molecular mass of actin in the myopathic muscle was smaller than in control. The diffuse actin band in Western blot suggested a proteolytic degradation of F-actin in the myopathic muscle. There was also a serious distortion in the mitochondrial structure. Cytochrome oxidase has a direct role in the formation of cristae and mutation in its components may be directly responsible for the abnormal structure.

Blotting, Western↗
PubMed1990

[Cytochrome C oxidase deficiency].

Cytochrome c oxydase deficiency, i.e. a mitochondrial myopathy was diagnosed in a patient suffering from generalized muscle hypotonia. The fatal case presented underlines the importance that within the clinical pattern of myopathies the distinct entities should be differentiated.

Adult↗
PubMed1984

Normal physical and mental development of 6-year-old children whose mothers were treated antenatally with prednisolone.

83 prednisolone-treated and 57 control children of a previous study demonstrating benefits of antenatal steroid prophylaxis of IRDS were reexamined at the age of 6 years. The prednisolone children were slightly higher and heavier, but no significant differences between steroid and control groups were noted in any other characteristics including IQ, psychosocial development, EEG, ophthalmology and audiology. THe results confirm the finding that antenatal steroid prophylaxis has no long-term hazards to the fetus.

Child↗
PubMedDate not supplied

Effect of quality of feeding on serum lipoprotein levels in premature infants.

The effect of the quality of feeding on serum lipoprotein levels was studied in 30 premature infants (mean gestational age 31.7 +/- 2.0 weeks, birth weight 1568 +/- 238 g). The neonates were classified into three groups fed with breast milk and two different formulae with low and high lipid contents. No significant differences in the serum triglyceride, total cholesterol, VLDL-, LDL-, and HDL-cholesterol values were found after six week's feeding of various lipid and protein intake.

Dietary Carbohydrates↗
PubMedDate not supplied

Type of feeding does not influence thyroid hormone levels in premature infants.

Thirty premature neonates (mean gestational age 31.8 +/- 3.90 weeks; mean birth weight 1569 +/- 236 g) were divided into three groups receiving breast milk, Robolact and Pre-Aptamil formula feeding. The infants with and without neonatal idiopathic respiratory distress syndrome (IRDS) were separately evaluated. No effect of the type of feeding and of a previously experienced IRDS on the blood T3-, T4-, and THS-levels could be demonstrated at the age of 6 weeks.

Humans↗