[Extra-osseous tumor uptake of bone seeking agents].
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Adult↗
Biomedical subjects
K Amoh
Publications and source records attributed to K Amoh.
[Experience of rapid high dose irradiation for superior vena caval syndrome (author's transl)].
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Adolescent↗
Case report of malignant splenic tumor.
Primary angiosarcoma and malignant lymphoma of the spleen are uncommon. We report such tumors in a 44-year-old-woman and a 51-year-old-man. The value of diagnostic imaging by US and CT is emphasized. These techniques can establish the solid nature of the mass and may be the first methods to suggest malignancy.
Adult↗
The disposition and pharmacokinetics of ketoconazole in the rat.
The disposition, biliary excretion, and pharmacokinetics of ketoconazole in Sprague-Dawley rats were determined after intravenous administration. Greater than 80% of the radioactivity after a 5 mg/kg iv dose of 3H-ketoconazole was excreted in the feces. Urinary excretion was essentially complete after 48 hr; however, fecal excretion was prolonged over a 7-day period. Biliary excretion of radioactivity averaged 54.3 +/- 18.0% of the dose over a 7.5-8-hr period in pentobarbital-anesthesized rats. The possibility of enterohepatic recirculation was examined using a linked rat technique. Less than 2% of the radioactivity was found in the recipient bile over 9-12 hr. In eight male rats, the plasma pharmacokinetics of ketoconazole, as determined by an HPLC assay with fluorescence detection, were as follows: VD = 655 +/- 91 ml/kg, Cl = 14.4 +/- 5.1 ml/min/kg, and t 1/2 = 35.0 +/- 12.3 min. Three of the rats were given an additional oral dose to determine absolute bioavailability. The time to peak was 30-60 min, and the bioavailability was 35.8 +/- 3.55%. Previous studies have indicated that ketoconazole is well absorbed in rats; therefore, the poor bioavailability is probably due to first pass metabolism. The prolonged fecal excretion of radioactivity from an intravenous dose was probably caused by slow elimination of ketoconazole metabolites.
Administration, Oral↗
Evaluation of renal and perirenal leiomyoma on US, CT, and angiography.
The findings of US, CT, and angiography were analyzed in five rare cases of renal and perirenal leiomyoma. The margin of the tumors was shown to be regular by each method, and the tumors were found to be heterogeneous by US and CT. US showed hypoechoic (80%) and mixed echoic (20%) echo patterns. CT revealed soft tissue density with contrast enhancement. Angiography disclosed hypovascularity (25%), and slight vascularity (75%), but no arterial encasement, A-V shunt, or vein invasion. Although no findings specific to the differential diagnosis of malignant tumors were found, benign tumors should be considered when the following signs are detected: (1) a large (more than about 5 cm), well-defined, regular abdominal mass with few symptoms, (2) a heterogenous hypoecho on US, (3) enhanced soft tissue density on CT, and (4) angiography without arterial encasement, A-V shunt, or vein invasion.
Diagnostic Imaging↗
MRI appearance of thorotrast-induced cholangiocarcinoma in a case of thorotrastosis.
The case of a 71-year-old man with thorotrastosis and a cholangiocarcinoma detected by MRI is presented, and the radiographic appearance of the cholangiocarcinoma is discussed. We concluded that MR is more useful for detecting Thorotrast-induced liver tumors than US and CT, but CT is more useful for the detection of Thorotrast deposits.
Adenoma, Bile Duct↗
Desmoplastic fibroma of bone.
We present a rare case of benign intraosseous desmoplastic fibroma, occurring in the tibial bone of a 48-year-old woman. The plain film features consist of a lytic, expansile lesion, in the metaphysis and epiphysis of the bone. We present a case involving the long bone in which the correct diagnosis was suggested by CT and MRI. The appearance of the lesion on CT and MR is described.
Angiography↗