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Biomedical subjects

K Amon

Publications and source records attributed to K Amon.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Distribution of salicylic acid and hydrolysis of acetylsalicylic acid in the human fetus in early pregnancy].

The materno-fetal transfer of salicylic acid and its distribution in the fetal organism was investigated in women of early pregnancy. Acetylsalicylic acid (Acesal) was administered orally in a single dose or in repeated doses at different times before legal interruption. The mean passage rates were about 6-15%. They were independent of the maternal serum concentrations of salicylic acid. The distribution of salicylic acid on the fetal liver, intestine, kidneys, lungs and brain was different. All fetal organs (9th to 15th week of gestation) studied exhibit an acetylsalicylic acid-splitting esterase activity. The esterase activity of the fetal liver was about 30% of the hydrolytic activity of the adult liver. The esterase activity was mainly located in the 105 000 X g-supernatant of cell homogenates.

Aspirin↗
PubMed1983

[Metronidazole in the treatment and prevention of infections in gynecology and obstetrics].

Metronidazole which has been widely used in the treatment of trichomoniasis urogenitalis is the most active agent available against obligate anaerobes.--In this review the present data about antimicrobial activity, mode of action, pharmacokinetic behaviour, dosage, clinical use in gynecology and obstetrics and side effects of metronidazole are outlined.

Bacterial Infections↗
PubMed1982

[Metronidazole for treatment of puerperal mastitis (author's transl)].

Pathogenic anaerobic bacteria may be among the causes of puerperal mastitis which, therefore, was treated by the authors with metronidazole (Vagimid) and with antibiotics, such as penicillin, oxacillin, erythromycin, and oxytetracycline. Best results were obtained by administration of metronidazole to patients in early mastitis. The frequency of incisions was reduced. The therapeutic results obtained from the use of metronidazole on patients with advanced mastitis were identical with those obtained from antibiotics.--Metronidazole concentrations were equal in serum and milk. No side effects were observed.

Anti-Bacterial Agents↗
PubMed1981

Pharmacokinetics of Metronidazole in pregnant women.

Pharmacokinetic characteristics of metronidazole were studied in 19 pregnant women with Trichomoniasis urogenitalis who had been hospitalized for legal abortion. All patients received 250 mg or 1.0 g metronidazole (Vagimid) per os in a single or multiple dose. Peak levels were reached 1-2 h after application. Mean serum levels of metronidazole were somewhat lower in gravidae than those in nonpregnant women. The mean elimination half-life values were 5.7 and 7.7 h after intake of 250 mg and 1.0 g metronidazole, respectively. As suggested by our pharmacokinetic results, the dosage regimen for treatment of anaerobic bacteria infection or parasitic infection in pregnant women can be the same as in nonpregnant patients.

Blood Proteins↗
PubMed1981

[Isolated and combined abdominal traumas (author's transl)].

A group of 89 patients treated for abdominal traumas between 1975 and 1980 is analyzed in respect of type and cause of accident, concomitant traumas and intra-abdominal organ lesion patterns. Isolated abdominal traumas are compared with abdominal traumas within an overall polytrauma. Complications and causes of death among the authors' own patients are reported. The relatively high overall mortality rate of 38% is due to the above-average proportion of multiple traumas amounting to 72%. Multiple intra-abdominal injuries or organs, simultaneous involvement of the thorax and necessary massive transfusions result in particularly unfavourable prognoses.

Abdominal Injuries↗
PubMed1981

[Use of metronidazole in treatment of postoperative obstetric infections (author's transl)].

Thirteen patients with abscess of the abdominal wall, including one case of endomyometritis following caesarean section, received metronidazole treatment (Vagimid), on the first two days of therapeutic action. The dosage was 500 mg twice per days, some of the applications combined with antibiotics. Proper healing was achieved in the majority of the cases. Clinical symptoms improved very soon, and hospitalisation could be shortened. Metronidazole was well tolerated. Microbiological tests were undertaken, and gas chromatography was used to establish from pus anaerobic metabolic products.

Abscess↗
PubMed1978

Pharmacokinetics and therapeutic efficacy of metronidazole at different dosages.

Metronidazole, a drug effective against certain protozoal and anaerobic infections, was given female patients with Trichomoniasis urogenitalis. Group I received twice daily 250 mg of metronidazole (supplied as 250 mg tablets Vagimid). Group II received in a single dose 1.0 g (4 tablets); and group III, 2.0 g (8 tablets). Serum and urine metronidazole levels were measured polarographically. Kinetic parameters were determined from the measured values of the concentration time curve by a computing program. An exact control of the therapeutic result was carried out. In all patients peak serum levels occurred within 1-3 hr and averaged 5.1 +/- 1.7 microgram/ml after 250 mg doses, 19.6 +/- 3.8 microgram/ml after 1.0 g doses and 40.6 +/- 9.3 microgram/ml after 2.0 g doses. About 35% of the administered dose was recovered in the urine in 12 hr and about 50% in 24 hr. Metronidazole shows protein binding of 10-20% equally in vivo and in vitro. Minimum trichomonacidic concentrations of nearly 1 microgram/ml were still present 12 hr after oral application of 250 mg metronidazole, and 24 hr to 36 hr, respectively after 1.0 g and 2.0 g daily doses. The cure rate was 100%. No serious side effects ocurred in any of the patients.

Adolescent↗
PubMed1976

[The transfer of drugs into the amniotic fluid].

On the basis of the present literature and our own results a review will be given about the importance of the physico-chemical properties of drugs and of different factors of biological system "mother, fetus and amniotic fluid" for the passage of drugs into amniotic fluid. The amniotic fluid is relieved as a possible distribution volume for drugs.

Amniotic Fluid↗