PubMed Health⌕ Search

Biomedical subjects

K Bergmann

Publications and source records attributed to K Bergmann.

At least 37 records · Page 2Linked to original sources

[Fatal complications of otitis 60 years ago].

The temporal bone collection of the ENT Department of the Charité Hospital in Berlin contains 128 cases from 1924 to 1941 of fatal complications of acute otitis media and cholesteatoma. In 1927 alone, one patient died on average every 2 weeks at Charité Hospital from fatal otitic disease. Lesions include labyrinthitis, meningitis, sinus thrombosis and brain abscess. Each case is documented by clinical history, autopsy findings and temporal bone sections. The reasons for the various features of each illness are briefly discussed.

Berlin↗

Human-papillomavirus DNA in cholesteatomas.

Cholesteatoma of the middle ear is a relatively common disorder, often with severe consequences. Histologically, the aggressively growing, bone-destructing form shows papillary growth and koilocytosis, which are characteristic of papillomavirus-induced lesions. A PCR (polymerase chain reaction) method using degenerate primers for the detection of any known or as yet unknown HPV (human papillomavirus) type was applied in screening 51 biopsies from 42 patients. A resulting 36% (16/45) of the cholesteatomas were found to contain papillomavirus DNA, which hybridized under stringent conditions with an HPV-II DNA probe. In 3 cases the presence of HPV-II DNA could be confirmed by sequencing the PCR products. The mere presence of this HPV DNA does not prove an etiological role of this group of viruses in the induction of cholesteatomas. It does, however, identify another group of human proliferative lesions putatively linked to papillomavirus infections.

Adolescent↗

The effect of activation procedures on neuroleptic-induced akathisia.

Two studies have been performed to evaluate the effect of activation tasks on neuroleptic-induced akathisia (NIA). In the first sample (30 patients) we found a consistent increase of symptoms during mental activation while motor activation led to a decrease. In a second study 34 patients with the same diagnosis were evaluated, using slightly different statistical procedures: while the effects of motor activation were corroborated, mental activation did not change NIA. Since mental and motor activation are usually considered to increase tardive dyskinesia and Parkinsonism, these measures might be helpful in differentiating NIA from other antipsychotic-induced movement disorders.

Adult↗

Combination treatment with noradrenalin and serotonin reuptake inhibitors in resistant depression.

Eight cases of resistant recurrent depression were treated with a combination of nortriptyline and a new serotonin reuptake inhibitor, with or without concurrent lithium therapy. Significant improvement was seen in all patients where other drug regimes and ECT had been ineffective. No adverse reactions occurred in any of our patients, seven of whom were elderly. The combination treatment was more effective than individual therapies alone.

1-Naphthylamine↗

Self-neglect and frontal lobe dysfunction.

An elderly lady, of superior verbal intelligence and with no severe psychiatric condition, severely neglected herself, and required prolonged day patient care. Brain scans showed selective frontal atrophy, and both traditional and new computerised neuropsychological testing demonstrated severe frontal dysfunction.

Activities of Daily Living↗