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Biomedical subjects

K Bergström

Publications and source records attributed to K Bergström.

At least 163 records · Page 9Linked to original sources
PubMed1981

Reliability of computed tomography in assessing histopathological features of malignant supratentorial gliomas.

A new method was developed whereby close comparisons can be made between components of a computed tomography (CT) image and neuropathological findings. This was achieved by a combination of intravital (terminal) CT, postmortem CT, and whole brain sectioning of formalin-fixed tissue. The method was applied in seven cases of malignant supratentorial astrocytic gliomas (Kernohan Grades III and IV) and in one case of thalamic ependymoma. The glioblastoma-like parts of the astrocytic gliomas were usually correctly delineated by postcontrast CT, although there were exceptions to this rule. Tumor components consisting of diffusely growing malignant astrocytoma were difficult or impossible to delineate by CT. Necrotic areas within the tumors were accurately outlined by postcontrast CT. Peritumoral edema was correctly delineated by CT, but growth of diffuse astrocytoma or the presence of astrocytic gliosis within this edematous area seems difficult or impossible to evaluate by current CT techniques.

Adult↗
PubMed1980

An automated turbidimetric immunoassay for plasma proteins.

The automated turbidimetric method presented allows a fast and accurate quantitation of plasma proteins. The analysis requires somewhat more antiserum than the radial immunodiffusion and the electroimmunoassay. However, this is compensated for by more rapid results and lower labour cost. The reference values for albumin, haptoglobin and IgG are the same as obtained by other immunological methods. The correlations with radial immunodiffusion and electroimmunoassay are good within the normal range. At high monoclonal IgG concentrations this method is better correlated to dye binding properties (scanning of electropherograms) than is the electroimmunoassay.

Blood Proteins↗
PubMed1980

Cerebral computed tomography in methanol intoxication.

In four of six patients with methanol intoxication, computed tomography (CT) showed necrotic changes in the area of the putamina. Hemorrhages were also seen in some cases. There was a clear relationship between the severity of the clinical symptoms and the CT findings, indicating the potential of CT for prognosis and possible therapy guidance.

Adult↗
PubMed1980

Effect of long-term treatment with human leukocyte interferon on various laboratory parameters.

Leukocyte interferon was given by i.m. injection as adjuvant therapy to 9 patients with osteosarcoma. The dose was 3 X 10(6) standard units daily for one month, and then 3 times a week for the next 17 months. Blood samples were drawn at intervals for a number of routine tests during the 18-month course of interferon administration and during the subsequent 18 months. On withdrawal of the interferon treatment, the mean Hb concentration rose significantly and the mean ESR fell significantly. There was no significant change in the leukocyte and platelet counts or in the alkaline phosphatase, alanine and aspartate aminotransferase or plasma protein levels.

Adolescent↗
PubMed1980

Cerebrospinal fluid ferritin in patients with cerebral infarction or bleeding.

By the use of a radioimmunoassay, ferritin was detected in the cerebrospinal fluid (CSF) of apparently healthy individuals at a mean concentration of 5.1 arb U/l, i.e. a level about 5% of the mean normal serum-ferritin concentration. Fourteen patients with acute cerebrovascular stroke or transient ischemic attacks (one case) were followed by serial determinations of CSF-ferritin during 2 weeks or more from onset of symptoms. After cerebral stroke all patients exhibited an increase of CSF-ferritin with peak levels between 4 and 6 days from admission. Those three patients in whom computed tomography showed cerebral bleeding had the highest peak CSF-ferritin was 28 +/- 11 arb U/l in the patients who had cerebral infarction without signs of bleeding. In seven patients CSF-ferritin returned to the control range after 2 weeks. The extent of the rise of ferritin in CSF could not be explained by damaged blood-CSF barrier. We suggest that the increment of ferritin in CSF of patients with cerebrovascular lesions may reflect an inflammatory response within the brain possibly mediated by macrophages.

Adolescent↗
PubMed1980

Pituitary adenomas: computed tomography and clinical evaluation in a follow-up after surgical treatment.

A study of the recurrence rate in 41 patients operated and postoperatively treated with irradiation for a pituitary adenoma was performed 10-15 years after operation. 15 of the 41 patients are now deceased among whom 1 had a known recurrence. 25 out of the now 26 living patients were investigated with a clinical examination, perimetry, computed tomography (CT), roentgen examination of the sella turcica and an endocrine evaluation. The outstanding capability of the CT to visualize pituitary adenoma recurrences was clearly demonstrated as this technique revealed recurrences in 6 patients, only 2 of which had progressive visual field defects and none progressive changes on plain sellar films.

Adenoma↗
PubMed1979

Serum enzymes after hip joint surgery.

The effect of hip joint surgery on routine serum enzyme values was studied. The increase in creatine kinase was most marked and normal levels were restored again after approximately 1 week. Asparatate aminotransferase was slightly elevated throughout the first two postoperative weeks. Alanine aminotransferase was essentially unchanged during the first three postoperative days in contrast to lactate dehydrogenase which reached preoperative values again after only 2--3 days. Alkaline phosphatase showed an increase after 1 week whereas S-amylase was essentially normal throughout the 2 weeks studied.

Adult↗
PubMed1978

Computed tomography of the brain in children with minimal brain damage: a preliminary study of 46 children.

Forty-six children aged 4 to 15 years with minimal brain damage (MBD) underwent computed cranial tomography (CT). The criteria used for a diagnosis of MDB was the presence of clinical features of a developmental disturbance of the central nervous system causing incoordination. CT revealed abnormalities in 15 cases (32.6%), consisting in cerebral atrophy, asymmetry or an anomaly.

Adolescent↗
PubMed1978

Acetylcholine receptor antibody in myasthenia gravis: purification and characterization.

Acetylcholine receptor antibody was measured in serum and IgG fractions from patients with myasthenia gravis using different analyses for antibody interfering with the toxin binding site and for antibody directed against other sites. No correlation was found between the concentration of receptor antibody as measured with the two assays. The different antibody activities also showed different isoelectric spectra. Receptor antibody was purified about 1000 times from IgG by affinity chromatography on a partially purified human skeletal muscle receptor preparation. The purified antibody was homogeneous in SDS-gel electrophroesis and showed a polyclonal pattern in agarose gel electrophoresis and isoelectric focusing. Both kinds of light chains were demonstrated. The results imply that the acetylcholine receptor antibody found in myasthenia gravis is heterogeneous and of multiclonal origin.

Acetylcholine↗
PubMed1978

Determination of acetylcholine receptor antibody in myasthenia gravis: clinical usefulness and pathogenetic implications.

Antibodies to cholinergic receptor structures were found in 75% of 76 Finnish and 93% of 175 Swedish patients with myasthenia gravis. The amount of antibodies showed a positive correlation to the severity of the disease, and was reduced during immunosuppressive treatment, and by thymectomy. Thymoma patients had high values. The antibody was also found in the cerebrospinal fluid. Two healthy newborn babies of myasthenic mothers had antibodies during the first weeks of life, in spite of no clinical symptoms. The occurrence of IgM antibodies before IgM antibodies in two patients during the early stages of myasthenia gravis suggests that the antibody is not a primary cause of the disease.

Adrenocorticotropic Hormone↗
PubMed1978

Studies on assays for plasma prekallikrein and for the monitoring of coumarol therapy.

Chromogenic substrates were used to assay prekallikrein, prothrombin and factor X. Plasma prekallikrein was contact activated and allowed the splitting of HD-Pro-Phe-Arg-PNA which has affinity for plasma kallikrein. Prothrombin was assayed in various ways (immunologically, after activation with Ecarin or in a less specific way). Determination of factor X is considered as a possible specific method in the monitoring of coumarol therapy.

Coumarins↗
PubMed1978

Haemangio-endothelioma of the orbit.

A case of infantile orbital haemangio-endothelioma was successfully treated with corticosteroids. Roentgenological and histological findings before and after treatment are described. It is suggested that an haemangio-endothelioma may be transformed into a cavernous angioma.

Female↗
PubMed1977

Immunoglobulins in myasthenia gravis: effect of human lymph IgG 3 and F (ab')2 fragments on a cholinergic receptor preparation from Torpedo marmorata.

Lymph IgG from patients with myasthenia gravis was shown to inhibit the binding of radio-labelled Naja naja siamensis alpha-neurotoxin to membrane fragments from the electric organ of Torpedo marmorata. This effect could be related to IgG subclass 3 and to the F(ab')2 fragment. These findings confirm the involvement of antibodies of postsynaptic structures in myasthenia gravis.

Animals↗
PubMed1977

Eye lens protection for radiological personnel.

Various radiodiagnostic procedures expose the eye lens of the diagnostic technician to radiations. With the aid of lead glasses with an attenuation of radiation equivalent to 0.25 mm of lead, the dose can be reduced by 90%.

Eye Protective Devices↗