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Biomedical subjects

K C Kanwar

Publications and source records attributed to K C Kanwar.

43 records · Page 3Linked to original sources
PubMedDate not supplied

Alterations in the hematological profile in rat following whole body gamma radiation with and without venoruton pretreatment.

The radioprotective effect of venoruton [O-(beta-hydroxyethyl)-rutoside] has been assessed in the hematological profile of Swiss albino male rats subjected to a single dose of 300 rads whole body gamma radiation. The results showed that the severity of the radiation-induced abnormalities in the red and white blood cells is significantly lessened by venoruton administered prior to radiation exposure.

Animals↗
PubMedDate not supplied

Hematological lesions in rat following heavy alcohol ingestion.

Hematological fluctuations following large alcohol oral administration (2 mL per animal per day) in rats were monitored at intervals ranging from 10 to 22 weeks and the findings were compared to those in control animals that were fed sucrose isocalorically. Following alcohol ingestion, there was a significant decrease in the total blood cellularity at all treatment intervals. A fall in the erythrocyte count per millimeter3 was accompanied by decreased hematocrit values and hemoglobin levels in the alcohol-treated animals. On the other hand, the MCV and MCH values were significantly elevated after alcohol ingestion. Despite overall leukopenia observed after alcohol ingestion, there was a significant increase in the absolute neutrophil count. The absolute lymphocyte count, however, fell significantly in the alcohol-treated animals. Eosinophils and basophils were not significantly altered by alcohol toxicity.

Alcohol Drinking↗
PubMedDate not supplied

Characterization of specific insulin binding sites in rat testis following induced diabetes and experimental starvation.

The presence of insulin-saturable binding sites in the rat testis have been demonstrated. Employing radioreceptor assay (RRA), the characteristics of insulin binding in both liver and testis of the normal (control) rats have been studied. Crude receptor binding at 37 degrees C after 18-20 hrs of incubation in Tris-HCl buffer at pH-7.5. The binding of 125I-insulin to liver and testis of the experimental rats, rendered diabetic for two months with single parenteral streptozotocin (STZ) administration (65 mg/Kg, BW, ip) was also studied. In the diabetic rats, the insulin binding in liver as compared to the control increased by over 92% (P 0.001); the increase in the binding of 125I-insulin to the testis of the diabetic rats however was not statistically significant. Similarly, insulin binding to the testis did not vary much after 3 days of starvation as against 84% (P 0.001) increase in the insulin binding to the liver of the fasted rats. These results suggest that testicular insulin receptors are similar to those of liver but may have a different physiological control.

Animals↗
PubMedDate not supplied

Enzyme changes in the brain, liver and kidney following repeated administration of mercuric chloride.

Alterations in the levels of selected enzymes have been studied in the liver, kidney and brain of mouse following mercuric chloride (1 mg/Kg body wt./d) administration for 10, 20 and 30 d. The activity of acid phosphatase increased in all the tissues, the highest increase was recorded in the kidneys which showed as much as 4.5 fold elevation following mercuric chloride administration for 30 d. Although the alkaline phosphatase activity in the liver and the brain increased following HgCl2 administration, the kidneys experienced a tremendous decline in this enzyme following the same treatment. Mercury-induced changes in ATPase were complex inasmuch as the nature and magnitude of these changes varied with the tissue as well as the duration of the treatment. Whereas the liver ATPase declined after all the treatment intervals, this enzyme increased in the kidney and brain following administration of HgCl2 for 10 d. However, both the kidneys and brain registered a substantial fall in ATPase activity when HgCl2 administration was continued for 30 d. The levels of both glucose-6-phosphatase and succinic dehydrogenase decreased in all the tissues following HgCl2 administration. Invariably, the magnitude of decrease was the highest after 30 d treatment with HgCl2.

Acid Phosphatase↗