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Biomedical subjects

K D Pletsityĭ

Publications and source records attributed to K D Pletsityĭ.

At least 37 records · Page 2Linked to original sources
PubMed1975

[Inhibition of tetanus poisoning by vitamin B-1].

It was shown in experiments on rabbits that preliminary injections of vitamin B-1 with their continuation after the administration of tetanus toxin increased the animal resistance to tetanus. A more distinct protective effect was noted after the administration of tetanus toxin in vitamin B-1 solution. A tendency to increase of resistance was observed after the use of the vitamin 2 hours after the toxin injection.

Animals↗
PubMedDate not supplied

[The effect of 24,25-dihydroxyvitamin D3 (dioxyvit) on Ca metabolism and immune status during chronic kidney failure].

Active metabolite of vitamin D3, 24R,25 (OH)2D3 (dioxyvit) was used at a daily dose of 100 micrograms in treatment of children affected with tubulointerstitial disease of kidney and with chronic glomerulonephritis under conditions of kidney insufficiency. The drug exhibited distinct normalizing effect on patterns of calcium metabolism: increase of total and ionized Ca2+ and of 25-OHD, decrease in concentration of parath hormone and osteocalcine in blood serum as well as on immunological parameters: restoration of decreased content of T- and 0-lymphocytes. Concentration of receptors of hormonal form of 1,25(OH)2D3 was found to be minimal in lymphocytes under conditions of chronic kidney insufficiency, while their expression, after the dioxyvit action, was detected only in patients with glomerulonephritis. Specific calcitropic effect of dioxyvit with simultaneous correction of vitamin D deficiency were apparently responsible for high efficacy of the drug in treatment of calcium metabolism and immunity impairments in children with renal deteriorations at the step of chronic kidney insufficiency.

24,25-Dihydroxyvitamin D 3↗
PubMedDate not supplied

[Development of vitamin D deficiency and immunologic disorders in children with glomerulonephritis].

Biochemical symptoms of vitamin D deficiency and a sharp reduction in the number of T-lymphocytes in the peripheral blood were recorded in children suffering from glomerulonephritis. During the combined therapy using the compound "oksidevit " (1-hydroxyvitamin D3) the parameters characterizing D-vitamin providing became normal, and the number of T-lymphocytes in the peripheral blood was recovered.

Calcitriol↗
PubMedDate not supplied

[1,25-Dihydroxyvitamin D3 receptors in lymphocytes and T- and B-lymphocyte count in patients with glomerulonephritis].

Content of receptors to hormonal form of vitamin D3, 1.25(OH)2D3, constituted 27.3 fmole/mg of protein in lymphocytes of peripheric blood of children with glomerulonephritis. In the patients concentration of total and ionized form of Ca2+ was decreased down to 2.04 mmole/L and 1.09 mmole/L, respectively, while an increase in parathormone (PTH) by 36% and a distinct decrease in 25(OH)D concentration (lower than 1.25 ng/ml) was found in blood; content of cAMP was also decreased in lymphocytes by 33%. At the same time, total content of T lymphocytes was decreased 1.5-fold in peripheric blood. Treatment with I-hydroxyvitamin D3 (1-1.5 mg daily, within 4 weeks) led to normalization of total and ionized form of Ca2+ and of 25(OH)D, but did not affect the PTH content in blood. Concentration of the receptors to 1.25(OH)2D3 was elevated up to 39.7 fmole/mg after I week of the treatment, whereas it was decreased to the initial level 24.8 fmole/mg within 4 weeks; simultaneous alteration in the cAMP content was observed in lymphocytes. Treatment with 1-(OH)D3 normalized also the T lymphocytes content in peripheric blood. The data obtained suggest that under conditions of glomerulonephritis only high content of receptors to 1.25(OH)2D3 in lymphocytes enabled to perform the cell response to the hormone effect.

B-Lymphocytes↗
PubMedDate not supplied

[Activity of lysosomal proteinases in the liver, spleen, thymus and peritoneal macrophages after immunization of mice with thymus-dependent and thymus-independent antigens].

Mice of the CBAxC97B/6 strain were immunized with sheep erythrocytes at a dose of 0.5 ml containing 5% and 25% of the cell suspension and with Vi-antigen at doses of 2 micrograms/ml and 10 micrograms/ml, respectively. Sheep erythrocytes caused dose-dependent stimulation of cathepsin B, C and H in spleen, whereas cathepsin B was activated 3.1-3.6-fold after administration of Vi-antigen. Functional state of the lysosomal proteolytic system did not alter in thymus in response to sheep erythrocytes, while Vi-antigen activated distinctly thiol-dependent proteinases. In peritoneal macrophages administration of sheep erythrocytes led to 2-5-fold decrease in activity of all the lysosomal proteinases studied (cathepsins A, B, C, D, H and L), however Vi-antigen exhibited direct dose-dependent effect on activity of cathepsins A, B, D and L. The data obtained suggest that T-independent reactions of the immune system were realized via thiol-dependent lysosomal proteinases.

Animals↗
PubMedDate not supplied

[Activity of lysosomal hydrolases and renewal of proteins in the rat liver, spleen, and thymus during antigenic stimulation and protein deficiency].

Activity of cathepsins B and C was increased 1.8-2-fold in spleen simultaneously with a decrease 3.8-fold in the rate of protein renewal in the tissue lysosomal fraction within 4 days after antigen stimulation of rats, maintained within 45 days on a diet containing 5% of protein. Activation of these thiol-dependent proteinases appears to occur in response to development of immunodepressive conditions and may be related to alterations in the rate of their biosynthesis.

Animals↗
PubMedDate not supplied

[The use of vitamins A and E for the correction of immunologic disorders in chronic alcoholic intoxication].

In experiments on BALB/c mice it has been shown that in chronic alcoholic intoxication the immune response to sheep red blood cells is drastically suppressed. Oral administration of vitamin A or E oil solution in doses 3000 and 5 IU/day, respectively, during 3 days, led to correction of the immune response to sheep red blood cells disordered as a result of alcoholic intoxication.

Alcoholism↗
PubMedDate not supplied

[Further study of immuno-correcting properties of vitamins A and E in experimental chronic alcoholic intoxication].

The experiments conducted on guinea pigs have shown that chronic alcohol poisoning induced by daily oral intake of 1 ml of 25% ethanol solution during a month has brought to suppression of the T-system immunity. Vitamin A used during 3 days in a dose of 30,000 IU results in partial normalization of the immunological parameters, while vitamin E given during 3 days in a dose of 50 IU provides absolute normalization of the immune status.

Adjuvants, Immunologic↗