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K Emori

Publications and source records attributed to K Emori.

29 records · Page 2Linked to original sources
PubMed1982

Epithelioid granuloma formation requiring no T-cell function.

Muramyl dipeptide (MDP), a minimal structure in bacterial cell walls essential for their adjuvant activity, was incorporated in a water-in-oil emulsion and injected into the footpads of nude rats devoid of functional T cells. MDP thus injected evoked massive epithelioid granulomas in the draining lymph nodes, indicating that MDP induced epithelioid granuloma formation requires no T cells. This finding with other data available strongly suggest that epithelioid granulomas can be induced without immunologic reactions.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1981

Epithelioid granuloma induced by muramyl dipeptide in immunologically deficient rats.

When WKA rats were either neonatally thymectomized or injected with anti-rat thymocyte sera, their T-cell functions were effectively suppressed. When neonatally thymectomized plus anti-rat thymocyte serum-treated rats were injected with non-immunogenic muramyl dipeptide in water-in-oil emulsion, they produced massive epithelioid granulomas. Essentially, no morphological difference was noticed between granulomas induced in untreated rats and in thymectomized plus anti-rat thymocyte serum-treated rats. These findings strongly suggest that muramyl dipeptide-induced epithelioid granulomas required no T cells for their formation. In contrast, the induction of adjuvant arthritis appeared to depend on the presence of T cells.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1980

Epithelioid granuloma formation by a synthetic bacterial cell wall component, muramyl dipeptide (MDP).

A synthetic muramyl dipeptide (MDP, N-acetylmuramyl-L-alanyl-D-isoglutamine) is a minimal essential structure that is contained generally in bacterial cell walls and is responsible for their many biologic activities such as adjuvant activity, pyrogenicity, and a capacity to confer resistance against bacterial and viral infections. We found that this MDP evoked dose-dependently massive organized epithelioid granulomas in guinea pigs, when injected in the form of Freund-type water-in-oil emulsion. Granuloma formation reached a peak at 3 weeks. A minimal effective dose of MDP was 0.1 microgram. Essentially, no difference was observed qualitatively among granulomas evoked by MDP, MDP plus antigen, and killed tubercle bacilli incorporated in the emulsion. Quantitatively, however, MDP was stronger in its granulomagenic capacity than tubercle bacilli. Antigenicity of MDP was not detectable. These findings support our proposal that MDP may be a chemical structure in tubercle bacilli essential for epithelioid granuloma formation and that the MDP-induced epithelioid granuloma may be of a nonallergic nature.

Acetylmuramyl-Alanyl-Isoglutamine↗
PubMed1978

Granuloma formation by synthetic bacterial cell wall fragment: muramyl dipeptide.

A synthetic muramyl dipeptide, N-acetylmuramyl-L-alanyl-D-isoglutamine, which possesses the same structure as that of a part of the peptidoglycan monomer of wax D of tubercle bacilli or bacterial cell walls was found to induce, when injected in water-in-oil emulsion, massive granulomas often accompanying abscesses in the site of injection and draining lymph nodes of guinea pigs and rats. The granulomas were composed mainly of epithelioid cells 2 weeks after injection and were indistinguishable from those induced by tubercle bacilli. The granulomas induced in rats were less mature than those induced in guinea pigs. Allergic reaction appeared to play no important role in the development of the muarmyl dipeptide-induced granuloma.

Animals↗
PubMed1978

Clinicopathologic characteristics of pulmonary acinar sarcoidosis.

In 101 patients with histopathologic and clinical features compatible with sarcoidosis, a radiologic acinar pattern occurred in about 20% and was always accompanied by bilateral hilar lymphadenopathy. The radiologically acinar pattern histopathologically revealed noncaseating epithelioid granulomas and accumulations of macrophages in the alveolar spaces. Blood vessels were usually not affected by granulomas. On the other hand, a reticulonodular pattern histopathologically showed granulomas with centrally situated veins. The acinar form seems to represent the early stage of pulmonary sarcoldosis, producing primarily intra-alveolar lesions.

Adult↗