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Biomedical subjects

K Gajkowski

Publications and source records attributed to K Gajkowski.

28 records · Page 2Linked to original sources
PubMedDate not supplied

[Fisher's syndrome].

The authors describe a 43-year-old man with ophthalmoplegia, ataxia and areflexia and with 0.42 g/l of protein in the cerebrospinal fluid. EMG disclosed some slowing down of the conduction velocity in the motor fibres of the extremities. Treatment with synacthen depot, cocarboxylase and vitamins gave a good effect. The described case corresponds closely to Fisher's syndrome and may be a special form of brain-stem encephalitis involving the mesencephalon.

Adult↗
PubMedDate not supplied

[Comparative evaluation of seizure provocation methods with sleep deprivation and Brietal in epileptics].

In 10 patients with suspected epilepsy in whom routine EEG investigations failed to demonstrate changes the sleep deprivation method and intravenous injection of 1% Brietal solution were used as provocation methods. The efficiency of both methods was compared. In cases in which sleep deprivation provoked appearance of pathological changes Brietal gave a similar result but evoked more frequently the manifestation of focal changes. In cases in which sleep deprivation was ineffective Brietal provoked slight changes in some cases only. Both methods may be used for provocation and Brietal may be more suitable in cases with suspected focal lesions.

Adolescent↗
PubMedDate not supplied

[Effect of phenytoin and carbamazepine on evoked potentials in patients with newly diagnosed epilepsy. Part I. Visual evoked potentials].

Pattern-reversal visual evoked potentials (VEPs) were recorded in 64 patients with newly diagnosed epilepsy. Before starting medication the patients with partial and primary generalized epilepsy, had prolonged latencies of the VEPs component P100, as compared with controls. VEPs were repeated after 3 months in 43 patients with focal epilepsy, during carbamazepine (22 cases) or phenytoin (21 cases) treatment. The plasma concentration of the drugs were within therapeutic levels. Carbamazepine but not phenytoin, was associated with prolongation of the P100 peak latency and induced increase of its amplitude, as compared with the baseline condition. The VEPs abnormality was most pronounced in patients whose seizures were poorly controlled. We conclude, that administration of carbamazepine or phenytoin, at therapeutic serum level, have minimal effect on the VEPs.

Adolescent↗
PubMedDate not supplied

[Effect of phenytoin and carbamazepine on evoked potentials in patients with newly diagnosed epilepsy. Part II. Brainstem auditory evoked potentials].

Brainstem auditory evoked potentials (BAEPs) were studied in 64 untreated epileptics with partial (58) and primary generalized seizures (6). Patients were randomized to have either phenytoin (PHT) or carbamazepine (CBZ) monotherapy. Follow-up recordings were made 3 months after PHT (21) or CBZ (22) monotherapy in 43 patients with partial seizures. Before treatment epileptic patients and controls did not differ in BAEPs results. All patients had therapeutic PHT or CBZ levels. PHT prolonged I-III and I-V interpeak latencies (IPL), and central conduction time (I-V) changes were correlated with the patients age. CBZ increased the latency of wave I and the central conduction time. The prolongation of I-III IPL was significant only for the group with partial secondarily generalized seizures and the III-V for the group with partial seizures without generalization. These results suggest similar effects of CBZ and PHT on BAEPs within serum therapeutic range.

Adolescent↗