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Biomedical subjects

K Gibiński

Publications and source records attributed to K Gibiński.

At least 37 records · Page 2Linked to original sources
PubMed1984

Ranitidine in the maintenance therapy of gastro-duodenal ulcer disease: Polish open multicentre study.

Our first stage 3-week trial (6) and second stage up to 6 weeks (7) showed that ranitidine provides the highest healing rate of 97% for duodenal and 95% for gastric ulcer. The study has been now prolonged for one year to assess the efficacy of maintenance therapy. Out of 258 patients who completed the second stage 232 voluntarily entered the open stage 3 in which they were given a single dose R 150 mg nocte, and were endoscopied after 4, 8 and 12 months. There were 153 duodenal and 79 gastric ulcers. 191 patients completed the study; no undesired effects were found and there was no medical reason to withdraw the drug from the long term use. Recurrent ulcer was found in 33.3% out of 126 duodenal ulcer cases, and in 29.2% out of 65 gastric ulcer patients who completed stage three. Sixteen percent of recurrent gastric ulcers and 26% of duodenal ulcers were asymptomatic. Recurrence rate was about twice as high in smokers as in non-smokers. These findings were compared with our long-term endoscopic survey of the natural history of peptic ulcer disease (8) in which yearly recurrence rate of duodenal ulcer was 68.4% and of gastric ulcers 73.5%, 14% of them being painless. This indicates that R is fairly well tolerated in long term use and may be useful to curb the ulcer recurrence rate.

Adult↗
PubMed1984

Evidence of improvement in deficient gastroenterological diagnosis--a regional experience report.

A similar study carried out in 1964-1975 showed that very low diagnostic efficiency in gastroenterology rose at the end of this period, supposedly due to the introduction of modern techniques. The present study was designed to evaluate the effect of new imaging techniques (computerized tomography, ultrasonography, gammagraphy and ERCP) in the routine diagnostic efficiency in the same department of gastroenterology between 1979-1983. The study was carried out in two series. In the first, 217 clinical diagnoses were compared with the autopsy findings, and 488 with the surgical findings in the second series. Diagnostic efficiency proved to be twice as high as 10 years ago (p less than 0.0005); the highest diagnostic level was attained in the upper digestive tract. The threefold improvement in pancreatic disease diagnosis from 22% in the previous study to about 60% now did not attain the same level of accuracy (p less than 0.001). The success was due to a 50% decrease (p less than 0.0005) in the number of false negative diagnoses, while false positives remained at the same level of about 10%. In contrast to earlier findings no great difference was found between younger and older age groups.

Aged↗
PubMed1982

Seasonal occurrence of abdominal pain and endoscopic findings in patients with gastric and duodenal ulcer disease.

Fifty patients with peptic ulcer disease were followed up to 1 to 5 years. Panendoscopy was repeated on the average of 5.6 times a year, also in patients who were actually well. The pattern of changes during on calendar year was a substantial comparative unit. The incidence and intensity of pain, erosions, and ulcers were registered in yearly charts, and the results were calculated per month from 100 yearly cycles. Pain appeared to be the most frequent symptom, being reported in 50% to 100% of visits in particular months. Its decrease in springtime and in August was significant at the level of p less than 0.5, whereas the increase in early autumn was more significant, with p less than 0.01, as was also the next decrease in December. Although pain appeared more often than ulcer niches, and although 4% of patients never felt pain, the only positive correlation found (p less than 0.05) was that between incidence of pain and of ulcer. Erosions occurring in 10% to 30% seemed to be the most constant feature in these cases, whereas the appearance of ulcers ranged from 15% to 60%. The lower ulcer incidence in August and in December was highly significant (in both, p less than 0.001).

Adolescent↗
PubMed1981

Ranitidine in the treatment of acute upper gastrointestinal haemorrhage--a comparative study. Preliminary report.

50 patients with acute gastrointestinal bleeding (GIB) were randomly allocated to treatment with i.v. Ranitidine 50 mg b.d., or to a standard conservative therapy. When possible i.v. administration was replaced by oral ranitidine 150 mg b.d. for a total of up to 10 days. Three subgroups included gastric ulcer, duodenal ulcer and haemorrhagic gastritis. The criteria were: the need for blood replacement, comparison of the endoscopic appearance before and after therapy, and the final outcome of treatment, including the need for surgery. Ranitidine appeared to be superior to the standard treatment, the advantages being due largely to the gastric ulcer cases.

Acute Disease↗