[Clinical evaluation of 67Ga-citrate scintigraphy in malignant lymphoma (author's transl)].
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Publications and source records attributed to K Hasuo.
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The role of radiological imaging in moyamoya disease includes screening of the disease based on clinical findings, evaluation of the changes in vasculature and brain parenchyma, and clinical follow-up. The imaging findings in moyamoya disease are classified as primary and secondary. The primary findings essentially consist of occlusion of the circle of Willis and collateral formation, including moyamoya vessel formation. The secondary findings include cerebral infarction, white matter lesions, atrophy, and hemorrhage. For the visualization of the primary and secondary findings as well as postoperative results, MRI and MR angiography are the most reliable methods and play important roles because of their excellent diagnostic yield and noninvasiveness.
BACKGROUND: The purpose of this study was to assess the angiographic incidence and appearance of the hepatic falciform artery (HFA) and discuss its clinical significance. METHODS: Hepatic angiograms of 53 patients obtained with digital subtraction angiography were prospectively evaluated with regard to incidence, anatomic features, and flow speed of the HFA. We analyzed whether the background of chronic liver disease affected the incidence of the HFA. Transcatheter arterial chemoinfusion or chemoembolization for liver tumors was performed in 33 patients. We noted the occurrence of supraumbilical skin complications. RESULTS: The HFA was observed in 13 (24.5%) of 53 patients on celiac or common hepatic angiograms. The blood flow of the HFA was slower than that of the peripheral hepatic arteries in all patients. No significant difference in the incidence of HFA between the 34 patients with chronic liver disease and the 19 patients with normal livers was found. One treated patient with an HFA and a history of gastrectomy developed a supraumbilical red skin rash. CONCLUSION: The angiographic incidence of the HFA is more common than previously reported. The delayed and persistent opacification of the HFA on hepatic angiograms caused by its slow blood flow is considered the key to its identification.
The prognosis of 27 patients with moyamoya disease was studied. The ages at onset ranged from 11 months to 4-11/12 years. Follow-up study was performed within 4 years from the onset in 13, 5 to 9 years in 5, and 10 to 15 years in 9. Transient ischemic attacks (TIA) occurred most often during the first four years and decreased thereafter. Intellectual deterioration and neurologic deficits increased with time. Outcome included no sequelae in five (19%), occasional TIA or headache alone in nine (33%), mild intellectual and/or motor impairment in seven (26%), requirement for special school or care by parents or institutions after reaching the teen years in three (11%), continuous 24-hour care in two (7%), and death in one (3%). Poor prognosis was correlated with an early age at onset and hypertension.
A boy developed a right hemiparesis at 13 months of age which disappeared spontaneously at 19 months. Computed tomography and magnetic resonance imaging revealed extensive low-density areas with left-sided predominance in the white matter at age 17 months. The flash visual evoked potential revealed abnormal findings of wave V. At 20 months of age, paraplegia developed; as it receded 3 months later, a left hemiparesis developed. At that time, computed tomography demonstrated a new low-density area in the right centrum semiovale which disappeared at 28 months of age concomitant with the recovery of the left hemiparesis. Overall, he had experienced 3 independent episodes, 2 of which corresponded to each of the lesions depicted by computed tomography and magnetic resonance imaging. Multiple sclerosis was diagnosed at 23 months of age which is earlier than in any previously reported patient. Unlike most typical findings of multiple sclerosis on computed tomography and magnetic resonance imaging studies, our patient demonstrated extensive white matter lesions.
We present a case of pituitary hypertrophy due to juvenile primary hypothyroidism with subsequent return to normal size after therapy. This clinical entity is well known, but there are few reports on its magnetic resonance (MR) findings. We stress the usefulness of Gadolinium-DTPA-enhanced (Gd-DTPA-enhanced) MRI in the differential diagnosis of pituitary hypertrophy and pituitary adenoma.
Ten patients with dural carotid-cavernous fistulas (CCFs) who presented with ophthalmic manifestations were studied using postcontrast computed tomography (CT), magnetic resonance imaging (MRI), and selective cerebral arteriography. The lesions of two patients were bilateral. An enlarged cavernous sinus (CS) was diagnosed in 6 of the 12 involved sides using postcontrast CT. An abnormal flow void in the CS was detectable in 11 of the 12 using MRI. A dilated superior ophthalmic vein (SOV) was demonstrated in all of the involved sides by postcontrast CT, and in 9 of the 12 by axial MRI. Thus, both postcontrast CT and MRI are relatively useful and complementary in the diagnosis of dural CCFs. Patients should be followed with selective cerebral arteriography for definitive diagnoses and for therapeutic planning.
We detected 23 intracranial lipomas using MRI. Among them were nine pericallosal lipomas, six lipomas at the dorsal surface of the midbrain, and eight in other locations. In this paper, six lipomas at the dorsal surface of the midbrain were analyzed. Five of these lipomas were in the quadrigeminal cistern and one in the left-sided quadrigeminal cistern. Excluding the smallest lipoma, five of the six lipomas had irregular margins and were broadly based on the surface of the midbrain. In these five cases, deformities of the brain parenchyma were observed adjacent to the lipomas. A mildly dilated ventricular system was observed in one of the largest lipomas in a quadrigeminal cistern. Based on their characteristic shapes and locations, we termed them "dorsal mesencephalic lipomas." Thus, the two preferential sites of intracranial lipomas were pericallosal and dorsal mesencephalic.
The magnetic resonance images of 16 patients with intradural-extramedullary spinal tumors, consisting of 11 neurinomas and five meningiomas were reviewed. The neurinomas appeared hypointense compared to the spinal cord on unenhanced T1-weighted images (T1WI) in nine of 11 patients, and hyperintense on T2-weighted images (T2WI) in nine of 11 patients. Neural foraminal extension was present in two cases. All 10 neurinomas were markedly enhanced; six of them exhibited ring-like enhancement on Gadolinium-DTPA (Gd-DTPA)-enhanced T1WI. The meningiomas appeared isointense on unenhanced T1WI in four of five patients and on T2WI in three of four patients. Three meningiomas showed moderate homogeneous contrast enhancement after the intravenous administration of Gd-DTPA. It is concluded that careful scrutiny of magnetic resonance images facilitates the differential diagnosis of spinal neurinomas and meningiomas.
Thirty-two patients with liver cirrhosis underwent cerebral magnetic resonance imaging (MRI) to evaluate clinical and subclinical portal-systemic encephalopathy (PSE). Symmetrically hyperintense globus pallidi were observed on T1-weighted images in all 11 patients with PSE and in 15 of the 21 patients with PSE. This abnormality was classified as grade I (bilateral globus pallidi with mild to moderate hyperintensity relative to white matter), and grade II (marked hyperintensity bilaterally in the globus pallidi with mildly increased signal intensities in the surrounding structures). Portal-systemic collateral vessels were demonstrated in 23 of 24 patients who underwent abdominal angiography. In 18 of the 19 patients with abnormal MRI, collateral vessels were supplied by the superior mesenteric vein with or without the splenic vein, including four patients with collaterals which were less than 10 mm in diameter. We concluded that hyperintense globus pallidi on T1-weighted images are significant manifestations of clinical PSE. When portal-systemic collaterals supplied by the superior mesenteric vein are observed, even if they are of small diameter, cerebral MRI should be performed to evaluate for subclinical PSE.
Using two 1.5-T magnetic resonance (MR) scanners, 82 venous angiomas (VAs) were imaged. There were 13 (16%) VAs associated with hemorrhagic lesions. Ten of the 13 hemorrhagic lesions were considered hematomas in the subacute or chronic stage, caused by VAs or coexisting cavernous hemangiomas. Two of the 13 were subacute intracerebral hematomas; the remaining one was a sequela of a hemorrhagic venous infarct. After analysis of our data, it was concluded that infratentorial VAs and deeply draining supratentorial VAs in relatively young adults, especially females, are relatively frequently associated with intracerebral hemorrhagic lesions. MR imaging proved useful for diagnosing VAs and associated hemorrhagic lesions.
Two cases of primary intracranial malignant lymphoma with high uptake of [18F]fluorodeoxyglucose [( 18F]FDG) are reported. Malignant lymphomas should be considered in the differential diagnosis of brain tumors with high [18F]FDG uptake in positron emission tomography studies.
The CT and clinical features of six patients with congenital renal arteriovenous malformation (RAVM) were reviewed to determine the characteristics of this condition. The most common symptom was hematuria. The CT images were characterized by masses of vascular density located in the renal sinus and surrounding the pelvicaliceal system with or without dilated renal veins. The exact size of the RAVM and the relation to the pelvicaliceal system were well demonstrated by delayed images or drip infusion technique, whereas the bolus injection technique was essential to document the vascular nature. The potential pitfalls in diagnosis that can occur if only an infusion study is performed are discussed.
PURPOSE: Our goal was to evaluate the ability of helical CT to identify and demonstrate the origins and courses of bronchial arteries, using the curved reformation technique, in patients undergoing bronchial arterial interventional procedures. METHODS: Thin section helical CT was performed on seven patients before bronchial arterial interventional procedures. The curved reformation technique was used to demonstrate the origins and continuous vessel tracing of bronchial arteries and compared with bronchial arteriographic findings. RESULTS: In all, 16 bronchial arteries were evaluated, 8 on the right and 8 on the left. The origins of 12 bronchial arteries were identified. In the demonstration of tracing vessels, seven right bronchial arteries and three left were classified as excellent or fair. CONCLUSION: Helical CT imaging with the curved reformation technique is helpful in identifying bronchial arteries, especially on the right, in patients with indications for bronchial arterial interventional procedures.
BACKGROUND/AIMS: Many authors have reported that Helicobacter pylori (H. pylori) is one of the major causes of gastritis and peptic ulcer. This study was conducted to evaluate the incidence of H. pylori infection and the curative effects of amoxicillin and omeprazole on H. pylori in the remnant stomach. METHODOLOGY: Biopsy specimens were obtained from 70 patients who underwent gastrectomy for gastric cancer. H. pylori was subsequently diagnosed by CLO test and culture of H. pylori. Gastritis was assessed by the scoring of four characteristic pathological parameters. Patients with positive H. pylori were eligible for the eradication study. Amoxicillin, 750 mg per day for 2 weeks, and omeprazole, 20 mg per day for 8 weeks, were administered to them. Endoscopic reexamination was performed 12 weeks after the initiation of treatment. RESULTS: The overall positive rate of H. pylori was 37.1%; 39.6% in Billroth I reconstruction, 0% in Billroth II reconstruction, and 55.6% in pylorus preserving gastrectomy, respectively. The positive H. pylori rate of Billroth II reconstruction was significantly low. However, there was no association of positive rate of H. pylori with time. There was no significant difference of gastritis scores between H. pylori infected patients and non-infected patients. The eradication rate was 70.0%. CONCLUSIONS: H. pylori was present in 37.1% of patients who underwent gastrectomy. Gastritis was not significantly severe in H. pylori infected patients. The treatment with amoxicillin and omeprazole was effective for these patients.
We report an unusual case of Kimura's disease. An 81-year-old Japanese woman was shown to have bilateral auricular masses that had begun to enlarge 6 years before. On CT scans, slightly high-density masses with faint contrast enhancement were seen. The masses were heterogeneous and hypointense on T1-weighted MR images, were slightly hyperintense on T2-weighted MR images, and showed heterogeneous enhancement after the administration of contrast material. Kimura's disease should be included in the differential diagnosis of bilateral auricular tumors.
Earlier reports on the angiographic features of MOC concluded that there may be hypervascularity and tumor stain but no A-V shunting, pooling, or vessel amputation as a result of the lesion. However, our cases demonstrated A-V shunting in MOC, and showed that the vascularity of this lesion can closely mimic that of malignant neoplasms. Therefore, the possibility of MOC should not be excluded because of the presence of A-V shunts or "tumor vessels" in suspected MOC lesion on plain radiography. These points are underscored by the findings in two MOC patients, whose cases are described.
Pulmonary sequestration is often found in children with recurrent pneumonia, but is not rare in adults. During the last 6 years (1985-1990), 6 patients with pulmonary sequestration were surgically treated. One 40-year-old patient had an extralobar sequestration, and 5 patients ranging in age from 14 to 26 years had an intralobar sequestration. The patient with extralobar sequestration was asymptomatic. In cases of intralobar sequestration, 4 patients were symptomatic. All 6 patients had an abnormal chest roentgenogram. Preoperative arteriography revealed anomalous blood supply came from a systemic artery in 4 patients. All cases with intralobar sequestration had a lower lobectomy, and one case with extralobar sequestration had an extirpation. Even in cases without any symptoms, there was the possibility of a microscopic infection in the sequestrated lesion with the occurrence of later symptoms. Therefore, patients diagnosed with pulmonary sequestration should be considered for surgical resection.