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Biomedical subjects

K Henning

Publications and source records attributed to K Henning.

At least 55 records · Page 3Linked to original sources
PubMed1985

The protective effect of 1-tert.butyl-4,4-diphenylpiperidine against the nigrostriatal neurodegeneration caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinson syndrome in humans and in monkeys. In the rat, treatment with MPTP for a month resulted in permanently reduced dopamine and serotonin levels in the caudate nucleus. However, if the rats were pretreated with budipine, no MPTP-induced reduction in the dopamine and serotonin levels in the caudate nucleus was observed although one month recovery and observation time had elapsed between the last budipine injection and decapitation. It is surmised that budipine antagonises the neurotoxic effect of MPTP.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed1985

[Space-occupying rectal cancer. Concept of the operation and early results in 15 patients].

In 1982 and 1983, 15 patients (14 women, 1 man) suffering from large tumors of the rectum and of the rectosigmoidal junction totally filling the small pelvis, underwent operation. Depending on the extent of the tumor, 8 patients underwent a hysterectomy (53.3%), 7 a resection of the small intestine (46.6%), five a resection of part of the bladder (33.3%), three a resection of the vagina (20%), two an extirpation of the bladder (13.3%), and one each a nephrectomy, a resection of the ureter, a resection of the pelvic vein, and a resection of the abdominal wall. In two cases an ileal conduit was applied, in three an ureter splint. Hospital lethality rate was 20% (3 patients) with an average hospital stay of 53 days. After an average observation period of 18.3 months, 8 patients were still alive. The probability of surviving 12 months was 63%. - The surgical concept applied is presented.

Aged↗
PubMed1985

The influence of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the levels of dopamine, serotonin and their metabolites in the caudate nucleus of the rat.

Until now it has been generally believed that N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) could induce a Parkinson-like syndrome only in man and in the rhesus monkey, a syndrome which begins with degeneration of the nigrostriatal system and is accompanied by a marked reduction in dopamine levels in the caudate nucleus. Rats, guinea pigs and cats subjected to comparable doses of NMPTP showed neither motor nor biochemical disturbances. In the present study it could be demonstrated, however, that long-term treatment of rats with a total dose of 116.9 mg NMPTP/kg brings about changes in the metabolism of the biogenic amines dopamine and serotonin in the caudate nucleus. The treatment reduced the dopamine and homovanillic acid levels to about 50% of their normal values, 3.4-dihydroxyphenylacetic acid also to 60% of the control levels. These experiments demonstrate that NMPTP, given in appropriate doses for a sufficient time, is capable of producing neurodegenerative changes in rats as well. This implies that the rat is a suitable experimental animal for studies with NMPTP.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗
PubMed1984

[Adjustment of synchronized intermittent ventilation with the Drager Company's SIMV Pulmolog].

When choosing an IMV frequency in a respirator, the aim should be to guarantee a minimum of ventilation. With most respirators the "time-window" for the synchronisation of the mandatory stroke volume is within the ventilatory cycle. Thus, the IMV frequency corresponds to the adjusted minimum mechanical ventilation frequency and can be increased only by the patient's spontaneous breathing activity. With the Dräger "Pulmolog", however, the spontaneous breathing phase--not the ventilatory cycle--is already determined by choosing the IMV frequency. This difference is most important for daily clinical practice, as the minimum IMV frequency may be below the adjusted one. The manufacturer has reacted by changing the data on the manufacturer's label.

Humans↗
PubMed1982

[Comparative examinations of different types of soda lime (author's transl)].

Three different types of soda lime (Dräger-Sorb 800, Sodasorb and Tricomed) were analysed both experimentally and in patients for their capability of eliminating CO2 from the anaesthetic circle system. In the experiment Sodasorb was exhausted already after 24 minutes (transmission of 0.6 vol-% CO2) while with Tricomed these data were reached only after 35 minutes and with Dräger-Sorb 800 after 40 minutes. Regarding measurements in patients the soda limes tested showed no significant difference in this field, but again Dräger-Sorb 800 was the best in eliminating CO2 (after a 2 hours application - 1.05 vol-% CO2 after the absorber, that is in the inspiratory gas flow), followed by Tricomed (1.38 vol-% CO2) nd Sodasorb (1.49 vol-% CO2). Considering its prolonged functional performance as well as its lower dust production Dräger-Sorb 800 can be regarded as the best soda lime being available especially with respect to almost equal expensiveness.

Anesthesia, General↗
PubMed1978

[Intractable renal and enteral loss of potassium in a case of Turner's syndrome (author's transl)].

A case of Turner's syndrome is presented; many congenital defects were detected. Predominant clinical findings were cheilognatoschisis, respiratory distress, caused by congenital bronchiektasis and chronic hypokalemia with paroxysmal attacks of paralysis and tetania. Hypokalemia was mainly due to gastrointestinal losses as a consequence of permanent vomiting in the presence of stomach atonia and hiatus insufficiency or because of "third space losses", while a subileus persisted chronically. Furthermore also a renal loss of serum potassium was evident in the patient's predialytic time. Basic renal diseases were pyelonephritis, renal damage from phenacetine abuse, or probably even a nephropathy due to potassium depletion. Uraemia was controlled by dialysis treatment and by a dialysate consisting of 7 and 6 mmol/l potassium respectively. The result of this intense therapy was physical rehabilitation and the patient finally could resume her professional work again.

Adult↗
PubMed1978

[Use of a human fibrin adhesive in nephrotomies].

Report on the use of a physiologic adhesive, a human fibrin product, in surgery of nephrotomies; the new technique allows the performance of nephrotomies for the removal of complicated and extensive lithiasis with minimal trauma to the renal parenchyma.

Fibrin↗
PubMed1977

[Experiences with a biological adhesive system (fibrin) in the dressing of kidney parenchymal wounds (animal experiment and 1st clinical experiences)].

We report on investigations describing the use of a biological adhesive system for tissue adhesion and local haemostasis. This system consists of highly concentrated native fibrinogen and thrombin. Clotting factor XIII is admitted for reinforcement of the fibrin network. In experimental partial kidney resection this system was used with excellent results. This experience led to successful application of this method in 15 patients who underwent partial nephrectomy for various diseases.

Animals↗