PubMed Health⌕ Search

Biomedical subjects

K I Panchenko

Publications and source records attributed to K I Panchenko.

36 records · Page 2Linked to original sources
PubMed1983

[Degree of lymphocytic infiltration of the epithelium in bladder tumors].

Lymphocytic infiltration of parenchyma and stroma of transitional cell tumors of human urinary bladder was assessed separately by quantitative morphometric procedures. The study established an increased level of lymphocytic infiltration of urothelium in areas adjacent to tumor matched by a relevant decrease in simple papillomas. Infiltration level remained unchanged in proliferating papillomas and papillomas with multiple carcinomas in situ. This parameter was raised in papillomas with local cell atypia, local invasion and single carcinomas in situ as well as in transitional cell cancers. These data are in collision with the hypothesis of progressive failure of cell-mediated immunity in tumorigenesis. The results suggest tumor growth stimulation by lymphocytes.

Carcinoma in Situ↗
PubMed1981

[Utilization of mononuclear DNA by regeneration epidermis].

In four series of experiments on random-bred mice, ten animals received 3H-thymidine in a dose of 1 micro Ci/g. An hour later 10 intact mice were subjected to cross allotransplantation of dorsal skin. The animals of both groups were sacrificed after 4 days. Twenty mice were injected with thymidine in the same way and sacrificed after one hour or after four days. The skin was subjected to histological examination using autoradiography. It has been found that proliferation of the epidermis around the allotransplant is not followed by substantial dilution of the label over the nuclei of its cells, so that in fact the total content of labeled thymidine in the allotransplant nuclei increases. At the same time the regenerating epidermis is infiltrated with mononuclears a quarter of which contain the label. It is suggested that mononuclears might be the source of additional thymidine for the regenerating epithelium.

Animals↗
PubMed1981

[Mononuclear epithelial infiltration in squamous cell skin cancer, allergic contact dermatitis and skin allograft].

Histological and electron microscopic examinations of cellular infiltration were carried out in squamous cell carcinoma of the skin in humans, in the zone of dinitrochlorobenzene allergic contact dermatitis in guinea pigs, and in allotransplant and the surrounding skin in mice. In all the processes studied, the epithelial part of the cell infiltration area was found to differ from the connective tissue area by cell composition. The epithelial sheets were shown to be infiltrated mostly with heterogenous lymphocytes as well as occasional macrophages forming simple and slit-like contacts with epithelial cells. It is doubtful whether lymphocyte-macrophage infiltration of the epithelium causes necrobiotic changes in its cells in the processes studied.

Animals↗
PubMed1978

[Relationship between mononuclear infiltration of the epidermis and its hyperplasia after auto- and allotransplantation of the full-thickness skin of mice].

Histological and histochemical studies of the back skin were carried out with morphometry on the 1st, 2nd, 3rd, 6th, and 9th days after auto- or allotransplantation of its full thickness graft in 60 lineal (C3H) and random-bred mice. In both kinds of transplantation, mononuclear infiltration of the epidermis of the graft and the surrounding skin was established. A correlation between the intensity of this infiltration and the thickness of the epidermis in the skin surrounding the grafts and in the autograft was established. In allotransplantation, there was no such correlation in the graft. No mononuclear cells were found in regeneration layers of the epidermis. It is suggested that epidermis regeneration is stimulated by autogenous lymphocytes.

Animals↗
PubMedDate not supplied

[The clinico-morphological characteristics of the regional blood circulation of the parotid glands in patients with chronic parenchymatous parotitis].

Regional circulation in the parotid glands was studied in 34 patients with chronic parenchymatous parotitis (CPP) with the use of clinical (rheography and coagulography) and morphologic methods. A relationship has been revealed between regional circulation changes and the inflammation severity, CPP stage, type of concomitant diseases.

Adolescent↗
PubMedDate not supplied

[The regional blood circulation of the parotid gland and the correction of its disorders in chronic interstitial parotitis].

Elevated vascular tone, lengthened time of intraglandular arterial bed filling, fibrinogenemia, elevated plasma tolerance to heparin were detected in 32 patients with chronic interstitial parotitis (CIP) during exacerbation and in a number of CIP patients with the remission of the disease. Correction of microcirculation disturbances is advisable during CIP exacerbation; in remission it may be effective in patients with the late stage of parotitis, in those with parotitis coursing along with diabetes mellitus, essential hypertension, or against the background of prolonged oral drug therapy (e. g. clofelin). Drugs correcting the microcirculatory disorders are conducive to a sooner alleviation of the inflammation and better and longer preservation of the function of the parotid glands.

Adult↗
PubMedDate not supplied

[The diagnostic significance of biopsy of the labial salivary glands in Sjögren's disease and chronic parenchymatous and interstitial sialoadenitis].

Histologic methods were used to examine biopsy specimens of minor (labial) salivary glands obtained to verify Sjogren's disease in 14 patients with this condition, 12 ones with chronic parenchymatous parotitis, and in 4 subjects with chronic interstitial parotitis. Sjogren's disease, chronic parenchymatous parotitis, and, to a lesser degree, chronic interstitial parotitis were found to be associated with development in the minor salivary glands of an immune inflammation with the predominance of features characterizing delayed-type hypersensitivity reaction presenting as mainly lymphoid macrophagal infiltration of tissue first near the ducts and then near the end portions. This or that degree of glandular lymphoid macrophagal infiltration is present during all periods of disease and it therefore cannot be considered as a process secondary in relation to extension of the secretory portion of the gland. These data may be useful in interpretation of morphologic changes in the minor salivary glands in various forms of chronic sialadenitis.

Adult↗