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Biomedical subjects

K Ia Gurevich

Publications and source records attributed to K Ia Gurevich.

At least 19 recordsLinked to original sources
PubMed1994

[Cryohemosorption--a method of removal of lipoprotein-antibody immune complexes and other atherogenic substances in patients with atherosclerosis].

The efficacy of extracorporeal cryohemosorption was estimated in the treatment of atherosclerotic patients in terms of the autoimmune theory of the pathogenesis of this disease. There was a slight decrease in the plasma levels of total cholesterol and triglycerides, there was over 2-fold reduction in the plasma levels of fibrinogen and fibronectin. All major components of apo B-containing lipoproteins and immunoglobulin G were found as part of the cryoprecipitate. An extremely high concentration of lipid hydroperoxides in the precipitate suggest that cryoprecipitation removes not only autoimmune complexes, but highly-atherogenic peroxide-modified lipoproteins. The three-fold decrease in the levels of lipoprotein-antibody complexes resulted in lower atherogenicity of apo B-containing lipoproteins. It is suggested that the mechanism responsible for beneficial clinical action of cryohemosorption sessions is largely associated with the removal of autoimmune lipoprotein-antibody complexes and peroxide-modified apo B-containing lipoproteins than correction of lipid metabolism.

Adult↗
PubMed1994

[The clinical trial of a Russian membrane plasma filter in patients under therapy].

35 procedures of plasmofiltration were conducted on the test series of domestic membrane plasmofilter in 25 patients suffering from atopic diseases, systemic affections of connective tissue, advanced atherosclerosis, etc. The filter proved promising in therapeutic patients. The procedure is easier to perform compared to centrifuge plasmapheresis, it can work under thin blood flow. However, centrifuge plasmapheresis has advantages over the above filtration in patients with hyperhydration, hemorrhagic syndrome, contraindications to large-dose anticoagulants.

Combined Modality Therapy↗
PubMed1992

[Intensive plasmapheresis: complications and their prevention].

Upon the analysis of 246 plasmapheresis sessions performed for autoplasma provision, the correction of the blood rheology and the decrease in endogenic intoxication of 216 patients, it was stated that the frequency of various reactivity and complications comprised 12.9%. The causes of these complications and the means of their prevention were analyzed.

Arteriosclerosis Obliterans↗
PubMed1992

[Clinical testing of hemo- and plasmosorption on the Aktilen hemosorbent].

The authors make an analysis of using hemosorption and plasmasorption in 43 patients with the help of fibrous sorbent "Actilen". The developed methods have a pronounced detoxicating immunocorrecting, rheocorrecting effect, exert mild aggressive influence on blood and can be used in treatment of surgical, therapeutic and infectious diseases. The following advantages are noted: high sorption and kinetic characteristics of the sorbent, domestic devices and materials, small volume of the filling of mass transfer devices, low cost.

Hemoperfusion↗
PubMed1991

[The effect of therapeutic plasmapheresis on changes in the rheological properties of the blood in bronchial asthma patients].

Bronchial asthma runs its course in association with marked blood viscosity which lies in a decrease of deformability of red blood cells and suspension stability of red blood cells, an increase of their aggregation capacity and of whole blood viscosity, of platelet proneness to decelerated and little noticeable aggregation, in hyperfibrinogenemia and hyperglobulinemia. Therapeutic plasmapheresis produces a favourable action on changes of the rheological blood properties in bronchial asthma patients. Plasmapheresis entails an improvement of whole blood viscosity and red blood cell aggregation, accompanied, however, by aggravation of the aggregation properties of platelets. Therapeutic plasmapheresis can be used for correction of the syndrome of high blood viscosity in bronchial asthma patients.

Adult↗
PubMed1991

[The prospects for using extracorporeal detoxication methods in disaster medicine].

A lot of specific injuries caused by catastrophes provoke endogenic intoxication. In this situation the application of extracorporal detoxication methods will be conditioned by pathogenetical mechanisms of their action. There are indications for ED management in mechanical injuries, prolonged squeezing effects, thermal injuries, acute poisoning, irradiation injuries, acute infectious diseases, acute reactivity state. The experience of 163 operations on 111 wounded in catastrophes proves the worth-while character of work in this sphere. 10 variants of extracorporal operations including combined methods were applied.

Accidents↗
PubMed1991

[Effect of hemosorption on the elimination of an amphotericin B derivative in experimental studies].

Possible extracorporeal removal of a novel water soluble derivative of amphotericin B (NWSDA) from the host was studied. The bench tests demonstrated that actilen, a fibrous carbon adsorbent, was the optimal carbon sorbent for sorption of NWSDA. It was shown in the acute experiments on animals that during the hemosorption the antibiotic blood concentration on the outlet of the column was significantly lower than that on the inlet. Still, the NWSDA concentration in the blood lowered slowly which was likely due to the return of the antibiotic to the blood from the tissues.

Adsorption↗
PubMed1991

[The basic principles of extracorporeal detoxication in military field surgery].

Extracorporal detoxication (ED) was used in 64 operations of 40 wounded with gunshot injuries, thermal burns and acoubarotraumata. ED was applied with plasmapheresis, plasmosorption, hemoxygenation, ultrafiltration and hemodialysis. Combinations of these methods also were used. Indications and contraindications for extracorporal management of blood were elaborated for each category of wounded. Alterations were made in the methods of operations with reference to the peculiarities of pathogenesis. Positive results were marked at 30 persons. The authors propose a scheme of indications, as well as basic principles and criteria of efficiency for ED management of surgical patients. The article makes a conclusion that these operations must be preferably realised at the stages of secondary care.

Contraindications↗
PubMed1989

[Experimental substantiation of the sorption of reinfused blood].

An analysis of results of experiments on the assessment of morphofunctional properties of the bacterio-contaminated blood has been made. A conclusion is drawn that it is expedient to use hemosorption in order to provide safe reinfusion in patients with massive blood loss and injury of hollow organs of the abdomen.

Abdominal Injuries↗
PubMed1989

[Complications of traumatic disease (their incidence, characteristics and causes].

An examination of 2033 patients has established that the conditions for the development of pyo-septic and pulmonary complications of a severe trauma appear in the period of shock. Each kind of complications of trauma disease is associated with a certain set of risk factors. The localization, character of the injury and kind of early posttraumatic intoxication are responsible for the structure of complication. The blood loss value and volume of the infusion-transfusion therapy are considered to be the most common risk factors of the development of complications.

Humans↗
PubMed1988

[Estimation of blood loss in mechanical injuries].

The examination of 2033 patients with severe mechanical injuries has shown that in most patients with traumas of the head, chest and upper extremities of the same localization (isolated or multiple) the volume of blood loss was not more than 20% of the circulating blood volume. Isolated and multiple injuries of the abdomen, pelvis, spine and lower extremities in 28-54% of the patients were followed by blood loss more than 20% of the circulating blood volume. Associated traumas in most cases were followed by massive blood loss (more than 40% of the CBV).

Abdominal Injuries↗
PubMed1988

[Early toxemia in patients with severe mechanical injuries].

The examination of 2033 patients with severe mechanical injuries has shown that early intoxication takes place in 30.3% of the patients. Patients with blood loss of 35-40% and more, receiving more than 1 l of preserved blood make a group of high risk. Intoxication was more frequent in patients with one localization of injury when it is an injury of extremities or abdomen. In associated injuries the development of intoxication is determined by localization and kind of the main injury and is dependent on association with severe traumas of the extremities and abdomen.

Blood Group Incompatibility↗