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Biomedical subjects

K Jährig

Publications and source records attributed to K Jährig.

At least 19 recordsLinked to original sources
PubMed1992

Transepithelial potential difference in the bronchial system of children with chronic bronchitis and bronchial asthma.

In 45 children with chronic non-specific respiratory diseases (CNSRD), 18 with bronchial asthma and 27 with relapsing or chronic bronchitis, the transepithelial potential difference (tpd) was measured in the tracheobronchial system (bronchoscopy under general anaesthesia). The statistical variation in the tpds was highly significant. In asthmatics with significant eosinophilia in the bronchial secretions of the main bronchus we found a tpd of 26.5 (+/- 8.5) mV and in bronchitics a tpd of 18.2 (+/- 6.3) mV. This suggests that the presence or absence of eosinophils in the secretions, the products of intermediate cell metabolism or different pathogenetic processes, could be responsible for the variety of change in the tpd measured in the respiratory tract.

Adolescent↗
PubMed1991

[Variability of percentile values of body measurements of newborn infants (with special reference to body weight)].

The percentile curves for fetal growth between the 25th and 42nd week of gestation calculated for more than 52,000 newborns in East Germany in 1985 were compared with the rates defined for the same population in 1973-74 and showed a significantly lower mean birth weight. Besides methodological differences (primarily a more precise estimation of gestational age in the new study by using ultrasound fetometry), the differences seem to be mainly the result of changes in the reproductive behaviour of the population over that period (decrease in parity). When comparing different populations independently of ethnic specificities, a number of modifying factors have to be taken into account which significantly influence the birth weight, namely: parity, spacing, age and stature of the mother. These variables have also to be remembered when assessing the maturity of newborns in order to standardize the birth weight in relation to mortality and morbidity. As a basis for calculating percentile curves the cumulative frequency distribution should be preferred, rather than assuming a normal distribution, since fetal diseases or developmental anomalies result in an uneven distribution with an over-representation of small for date fetuses. The selection of data for calculating normal values must be rejected because of the arbitrary decisions which this entails.

Anthropometry↗
PubMed1991

[Gestational age related correction of birth weight by parity. Body height and weight of the mother].

Corrections to the real birthweight of infants are proposed from the 28th to 42nd week of pregnancy. These take account of the influence of parity and maternal height and weight. The effect of these three characteristics on the birthweight is calculated both one and two dimensionally by combining the characteristics with the actual duration of pregnancy. Thus, for example, after 40 full weeks of pregnancy 560g of the birthweight would be considered the weight correction. For newborn infants of relatively short light-weight mothers, this account should be added to the real birthweight ascertained, and for the babies of relatively tall, heavy mothers it would be subtracted. Only after this correction can the two dimensional classification of neonates into hypotrophic, eutrophic or hypertrophic take place according to birthweight and duration of gestation.

Adult↗
PubMed1990

[Recommendations for the diagnosis and therapy of meningitis, Waterhouse-Friderichsen syndrome and encephalitis in childhood].

Representatives of the working group of "Neuropaediatrics" and "Infectology" like to present recommendations on diagnostics and treatment of infectious diseases on the CNS. Individual opinions can not be considered in recommendations always. Therefore we have to understand these recommendations in this way that individual decisions will not be restricted in special situations.

Child↗
PubMed1990

Measuring the impedance of erythrocytes in patients with cystic fibrosis.

A study of the dielectric properties of fresh, washed erythrocytes from three groups of 13 children, one with cystic fibrosis, and one each of healthy children of comparable age and comparable weight, was conducted after resuspension in their own plasma or in sodium phosphate buffer. The erythrocytes of the patients with cystic fibrosis showed significant variations in impedance, especially compared to the control group of comparable age. Further studies are required to ascertain whether these results are of diagnostic significance.

Child↗
PubMed1990

[Birth weight of newborn infants in relation to body height and body weight of parents with special reference to duration of pregnancy].

Using the data of the 1985 GDR somatogram standards (birthweight percentiles calculated from 51,570 liveborn singletons) the impact of parental weight and length on the birthweight were calculated. Peristatic factors in combination with the genetic 'anlage' act first of all via maternal weight. Body height and/or length of mother and father are more representative for the genetic constitution. Their impact on neonatal weight seems to be less significant, however statistically calculable. The paternal 'anlage' is relatively modified by the intrauterine environment (maternal constitution).

Birth Weight↗
PubMed1990

Relevance of socio-economic data for the establishment of solution models based on international statistical material.

Using the official data of WHO statistics, the impact of some social, biological and medical factors on infant mortality rates (IMR) was compared for countries with very high, high, moderate and low IMR: Factors reflecting a low quality of life (illiteracy, low level of women's education, low urbanization, malnutrition etc.) showed a highly significant statistic correlation with increased IMR. The lack of a nationwide family planning program and a low level of medical care (prenatal care, presence of medical personnel during delivery, availability of contraceptives etc.) act in the same direction. In developing countries the GNP per capita did not markedly influence the IMR nor the rate of infants of low birth weight (UGR). One of the main reasons of this phenomenon is probably the wide gap of the income between different social groups in these countries. In contrast to this the GNP in economically developed countries (Europe, Australia, North America) correlates very closely with IMR and UGR. The impact of family planning differs between countries with legally artificial abortion and those with a more restrictive legislation. The nutritional status (i. e. in these countries hyperalimentation) shows a positive correlation with UGR but no impact on IMR. Some countries (in Europe Greece, Spain, Ireland/Yugoslavia, Romania) show a significant deviation (positive/negative) from the mean calculated according to the WHO data. These deviations can be (and should be) analysed for detecting and evaluating factors which could be influenced by strategies of social or/and medical interventions in order of further improvement of IMR.

Data Interpretation, Statistical↗
PubMed1990

[Neonatal percentile values for the GDR--1985. Correlation of body weight and length in newborn infants (calculation of birth weight/body length in cm. with reference to gestational age)].

Taking account of the gestational age (28th to 42nd completed week of pregnancy) the sex-related ratio of birth weight to length (g/cm) for newborn infants is reported. This shows that observation of the correlation between birth weight and length with reference to gestational age makes a more accurate classification of newborn infants possible, rather than using a two dimensional classification (birth weight week of gestation).

Birth Weight↗
PubMed1989

Neonatal jaundice in infants of diabetic mothers.

357 IDMs and 20 healthy newborns of non-diabetic mothers were examined at term for body measurements, red blood cell count, serum bilirubin, cord blood insulin and blood glucose during the first postnatal week. The stage of maternal diabetes did not influence the course of neonatal bilirubin levels, but the IDMs had prolonged and higher bilirubinaemia compared with the controls. Hyperbilirubinaemia was found to be most prominent in newborns with an increased birthweight/length ratio and was not simply related to macrosomia (LGA). These infants had significantly lower blood glucose concentrations immediately after birth, whereas cord blood insulin was found to be identical between the IDM sub-groups. Bilirubinaemia in heavy for length infants was slightly correlated to haematocrit. For the pathogenesis of hyperbilirubinaemia in IDMs induction of heme oxygenase (due to a lack of energy provision following a phosphorylation disorder) is discussed. Nutritional support (early feeding, glucose infusions) does not affect the course of bilirubinaemia.

Bilirubin↗
PubMed1989

[Day care management].

With the changing structure of pediatrics the emphasis of medical care (also of specialized care) has more and more shifted to the outpatient departments. For complicated diagnostic procedures of intermediate treatment in acute illness day-care on a special ward is a useful compromise with increasing importance. Own experiences in this way of medical care are exemplarily discussed.

Child↗
PubMed1989

[Diagnosis and treatment of acute otitis media in children. An analysis of the status in the Rostock district].

Over a period of 3 months a complete record was kept in 8 large medical institutions (in the Rostock county) of all children with acute otitis media and an analysis was made of the customary medical procedures followed by doctors for the diagnostics and treatment of these cases. Of the 761 patients (407 boys and 354 girls) 90% were babies and infants; more then 50% of these cases were suffering from otitis media serosa; 25% of the total did not receive antibiotics. A systemic antibiotic therapy was usually prescribed "blindly" and preference (83.7%) was given to penicillins and Berlocombin (a trimethoprim sulfonamide compound). In more than 2/3 of the cases the treatment was given by a paediatrician alone, in less than 10% of the cases only by the ENT specialist and the rest were treated by both departments. It would be advisable to start now to rethink the medical procedures related to initial bacteriological diagnostics as well as the local treatment of the auditory channel. In addition, there is an urgent need for a general "Recommendation on the diagnostics and therapy of otitis media acuta in children". This is now being prepared and should be approved by both specialist associations.

Adolescent↗
PubMed1989

[Pathogenesis of bilirubin encephalopathy and subsequent therapeutic consequences].

At present the classic "kernicterus" has nearly disappeared, but toxic effects of bilirubin, nevertheless, play an important role in the etiology of late neurologic sequelae in VLBW infants. Even in very low concentrations of serum bilirubin CNS damages have to be expected when other metabolic disturbances induce the opening of blood-brain-barrier. Since safe criteria for predicting toxic effects of bilirubin do practically not exist, in VLBW infants with perinatal metabolic disorders early preventive phototherapy is indicated to keep the serum bilirubin level as low as possible. Experimental studies in animals showed brain protective effects of barbiturates apart from enzyme induction.

Blood-Brain Barrier↗
PubMed1989

[Multicenter study of obstetrico-perinatologic quality control in the Rostock district. I. Comparative medical statistics].

Report about outcome-quality assessment in obstetrics and perinatology using an uniform check list for data collection in the district of Rostock. Various possibilities of outprint of the results in 1985 are demonstrated. For daily data collection in obstetrics a special book has been developed. The investigation concerns a data pool of more than 55,000 deliveries. Considering a trend of the results the following optimal criteria in obstetrics and perinatology are postulated: (table; see text) The check list of the Society of Perinatal Medicine of the GDR for obstetrical and neonatal data collection should be generally used. The soft ware for the computed data analyses has been developed by the "Rechenzentrum der Ernst-Moritz-Arndt-Universität Greifswald". Analysis and output of obstetrical and perinatological datas by means of a personal computer are prepared.

Birth Rate↗
PubMed1989

[East German percentile values for newborn infants--1985 relation of age, parity, body weight and height of the mother and the birth weight of newborn infants].

Based on an analysis of very comprehensive data material multidimensional investigations on connections between age, parity, weight and height of mothers and birth weight of infants have been made. Maternal height as well as maternal weight have a considerable influence on birth weight of infants. At the same maternal height infant birth weight will rise in connection with the rise of maternal weight. Maternal age, parity and weight are correlated variables. The older a woman, the higher on average is not only her parity but at the same her weight, too. The rise of maternal weight per year in the statistic mean amounts to 401 g. Moreover, at the same age like primiparae second and subsequent parae are of higher weights so that partly maternal weight contains indirectly not only maternal age but also maternal parity. The following range of the influencing factors maternal height, weight, parity and age on birth weight can be given: 1. Height and weight as relatively equivalent factors, 2. parity and 3. age.

Adolescent↗