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Biomedical subjects

K Kumar

Publications and source records attributed to K Kumar.

At least 217 records · Page 12Linked to original sources
PubMed1985

Pharmacokinetic evaluation of cefoperazone in infants.

The pharmacokinetics of cefoperazone were evaluated in 25 infants (mean age, 26 days) after intramuscular and intravenous routes of administration. The levels in blood that were achieved were severalfold higher than those required to inhibit common pathogens. The mean half-life of 240 min was one-half of that observed in 1- to 2-day-old infants but about twice that seen in adults. Further evaluation is needed to study the efficacy of the drug in infants and children.

Cefoperazone↗
PubMed1985

Air weapon injuries in children: a case for education.

The results of the first 6 months of a 2-year prospective study on the frequency, severity and methods of prevention of air weapon injuries to children are reported. Twenty-eight cases presenting to an urban paediatric accident and emergency department have been analysed. Nineteen of these were males between the ages of 10 and 16 years. At least 18 incidents occurred in public places. The five most serious injuries were of the orbit, face and abdomen. Another nine injuries were near vital structures. Education is needed on the existing guidelines for the safe use of air weapons.

Adolescent↗
PubMed1985

Cast syndrome.

Explore the source record for details and available documents.

Casts, Surgical↗
PubMed1985

Deep brain stimulation for alleviating chronic intractable pain.

The authors present their 4-year experience with 18 patients who had deep brain stimulation. Most were referred because of chronic pain of varied etiology. All conventional modalities of management had failed. Both the paraventricular gray matter and the sensory thalamus were target sites. The 18 patients underwent a total of 21 implants. Follow-up ranged from 6 months to 4 years with moderate relief of prestimulation pain in 14 patients (77%). Patients with failed back syndrome secondary to multiple disc operations fared well. Patients with pain secondary to progressive neurologic disorders or cancer had only short-lived benefits, while those with pain from cauda equina injury or vascular disease had a poor result. Deep brain stimulation appears to be an effective means of controlling chronic pain in selected cases.

Adult↗
PubMed1984

Effect of the chemosterilant bisazir on the eggs of Earias fabia stoll.

Bisazir-induced inhibition of nucleic acids and protein, and enhancement of free amino acids in the eggs of treated Earias fabia (Lepidoptera; Noctuidae) is reported. The degree of alterations in various crosses followed: T male X T female greater than UT male X T female greater than T male X UT female, which was also reflected in the weight loss of eggs. The alterations have been attributed to the abnormalities in the developing embryos due to genic imbalance in the spermatozoa, nurse cells and oocytes, ultimately leading to embryonic death.

Amino Acids↗
PubMed1984

Malathion toxicity: in vivo inhibition of acetylcholinesterase in the fish Brachydanio rerio (Cyprinidae).

Acetylcholinesterase (AChE) activity in the nervous tissue (brain) of the fish Brachydanio rerio was significantly inhibited by exposure to the organophosphorus (OP) pesticide, malathion. The inhibition was dose- as well as time-dependent. The fish survived even when the activity of the enzyme was inhibited by 90%. There was a significant recovery in the activity of AChE when malathion stress was lifted.

Animals↗
PubMed1984

Mild analgesics and the accident and emergency department--cost and safety more important than potency?

A prospective controlled trial involving over 1000 patients did not reveal any difference between four drugs commonly used in accident and emergency departments for the relief of mild to moderate pain. There were no significant variations in therapeutic effect, side-effects or patient compliance. When considering the supply of analgesics which may be no more potent than those available without prescription from retail chemists, cost and safety are more important than analgesic effect. By restricting the choice of analgesics available, the accident and emergency department should be able to increase awareness among its staff of the actions and side-effects of a small number of prescribed drugs and to contain costs.

Acetaminophen↗
PubMed1984

Evaluation of cefotaxime in bacterial infections.

Cefotaxime, a third generation cephalosporin antibiotic, was evaluated in 26 infants and children for the treatment of documented or suspected bacterial infections, including pneumonia (10 cases), soft tissue skin infection (13 cases), and urinary tract infection (3 cases). An average daily dose of 60 mg/kg in 3 to 4 divided doses was administered parenterally for an average of 7 days. In 14 of the cases, primary pathogens, including Haemophilus influenzae b (resistant to ampicillin), Staphylococcus aureus, Staphylococcus pyogenes, Streptococcus pneumoniae and Escherichia coli, were eradicated. Clinical recovery occurred in each case. Blood levels at different time intervals and biological half-life were similar to those reported for adults. Mild and transient side effects observed were elevation of SGOT in two cases, alkaline phosphatase in one, and eosinophilia in one case.

Alkaline Phosphatase↗
PubMed1984

Poly-syndactyly of hands and feet with talipes equino-varus. An unusual combination.

A case of a fifteen year old male with unusual congenital anomalies of hands and feet (Poly-syndactyly) is presented. There was associated talipes equino-varus deformity of the left foot with bilateral duplication of great toes. Both hands appeared like a cup but the patient was able to carry out his routine activities. The purpose of this report is to document a unique 'isolated' congenital anomaly.

Abnormalities, Multiple↗