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Biomedical subjects

K Maejima

Publications and source records attributed to K Maejima.

At least 91 records · Page 5Linked to original sources
PubMed1978

Provocation of pseudomoniasis with cyclophosphamide in mice.

After treatment with cyclophosphamide, a fatal syndrome was found in mice contaminated with Pseudomonas aeruginosa. The syndrome seems to be caused by P. aeruginosa from the intestine, and the liver is suspected to be the most important target organ.

Animals↗
PubMed1978

[Distribution of Pseudomonas aeruginosa in experimentally infected mice (author's transl)].

The distribution of experimentally administered Pseudomonas aeruginosa was studied in germfree CF no. 1 mice, barrier-sustained DDD mice with or without oral treatment of aminobenzyl-penicillin and conventional DDD mice. On day 1 after oral administration of 8 X 10(7) organisms, more than 10(8) of organisms/g were recovered from the feces of ex-germfree mice and the number was maintained during the experiment. On the other hand, from barrier-sustained mice with antibiotic treatment and those without the treatment, 10(4-7) and 10(3) organisms were recovered, respectively. In all of monoassociated mice and some antibiotic-treated barrier-sustained ones the organisms were recovered also from the lungs, liver, spleen and kidneys. In conventional mice, however, no organisms were recovered from the internal organs throughout the experiment, while some were detectable from the intestinal tracts. The distribution of the organisms in naturally infected mice appears to be similar to that of experimentally infected animals with antibiotics.

Ampicillin↗
PubMed1976

[Efficiency of microbe filtration of air filter for rearing germfree animals (author's transl)].

Filtration efficiency of 3 types of air filter frame and cylinder (Fig. 1) was examined by culture of the air obtained from the operating isolators at intervals of 3 to 21 days. The air of isolator was bubled in 30 ml of nutrient broth for 30 or 120 minutes (4approximately15 l/min.) and each of 1 ml of the broth was inoculated into thioglycollate medium (TGC), cooked meat medium (CMM), heart infustion broth (HIB) and glucose peptone water (GPW). The media were incubated for 7 to 14 days at 30 or 25 degrees C. As seen in Table 1, microbes could be effectively removed through all types of filter for over 10 months, though there were a very few positive cases suggesting technically acidental contamination at sampling.

Air Microbiology↗