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Biomedical subjects

K Markiewicz

Publications and source records attributed to K Markiewicz.

At least 37 records · Page 2Linked to original sources
PubMed1989

[Value of the analysis of left-ventricular systolic time intervals in the diagnosis of ischemic heart disease provoked by intravenous infusion of isoproterenol].

The aim of the study was to evaluate the value of analysis of left ventricular systolic intervals during Isuprel test in diagnosis of ischemic heart disease. 30 patients with ischemic heart disease without myocardial infarction in the past (group I) and after myocardial infarction (group II) as well as 15 healthy persons (group III) underwent the study. Electrocardiograms and polycardiograms were analyzed by means of Weissler's method. In patients with CAD during Isuprel test decrease of QS2I, LVETI, LVETI/S1S2 and increase of Q-1, ICT, PEPI, PEP/LVET were stated in comparison with healthy persons. Sensitivity of Isuprel test estimated by ST segment analysis was 80%, specificity 100%, predictive value for CAD confirmation 100% and for its exclusion 71.4%. Diagnostic value of Q-1, QS2I and LVETI intervals and PEP/LVET index did not statistically significantly differ from ST segment diagnostic value. Sensitivity of Isuprel test estimated by means of these intervals analysis was 63.3%, specificity 93.3-100%, predictive value for CAD confirmation 95-100%, and for its exclusion 56-57.7%. Analysis of left ventricular systolic intervals during Isuprel test is a valuable complement of an ECG examination.

Adult↗
PubMed1989

[Effect of a single dose of captopril on left-ventricular function in patients with chronic congestive cardiomyopathy].

In 15 patients with mild, chronic congestive heart failure the effect of a single dose of captopril (25 mg/m2 b.s.) on heart rate, systolic and diastolic blood pressure as well as on left ventricular function was studied at rest and after a submaximal physical effort. Preejection period (PEP), left ventricular ejection time (LVET) and the contractility index PEP/LVET were polycardiographically determined++. Left ventricular end diastolic volume (DVol), and systolic volume (SVol), ejection fraction (EF), stroke volume index (SVI) and cardiac index (CI) were estimated using two-dimensional echocardiography. Obtained data indicate, that in patients with chronic, congestive heart failure, a single dose of captopril lowers blood pressure at rest without significant changes of hemodynamic parameters, but improves left ventricular function during physical effort.

Adult↗
PubMed1989

[Evaluation of the effect of nifedipine in patients with chronic congestive heart failure].

18 patients with II NYHA class chronic congestive heart failure (CCHF) had been given nifedipine (Cordipin) 54.4 +/- 12.0 mg (day) for 6 weeks (group I). In 25 patients with III--IV NYHA class CCHF after 2-week optimal improvement of a clinical state with digoxine (D) and furosemide (F), nifedipine (N) had been added for 2 weeks/mean daily dose -- 40.8 +/- 12.8 mg (group II). Estimation of a left ventricular function using 2-DE and a submaximal effort tolerance as well as clinical examinations were carried out initially, after 2 and 6 weeks in group I, whereas in group II post D, F 2-week therapy and after next 2 weeks of combined D, F, N treatment. Nifedipine significantly increased ejection fraction from 44.2 +/- 13.0% to 49.0 +/- +/- 12.6% and decreased myocardial oxygen demand factor from 23.36 +/- 9.81 to 21.08 +/- 7.55 X 10(3) (p less than 0.05). Nonsignificant but marked increase of diuresis, cardiac and stroke indices as well as body weight loss were observed. Nifedipine addition to D and F neither improved nor deteriorated examined parameters in patients with III-IV NYHA class CCHF. Nifedipine did not also improve the submaximal exercise tolerance in both groups.

Adult↗
PubMed1988

[Effect of ergonovine and the cold stress test on time intervals of left ventricular systole and their significance for the diagnosis of coronary heart disease].

In 20 healthy test persons and 44 patients with a coronary heart disease without stenocardia at rest the ergonovine and the cold pressure test were performed. During the tests the ECG in 12 standard leads and the mechanocardiogrammes were registered, from which the time intervals of the left-ventricular systole were calculated. From the analysis of the pectanginous complaints and/or from the changes of the ST segment for the diagnosis of the coronary heart disease a sensitiveness of the ergonovine test of 40% was obtained, whereas the sensitiveness of the cold tolerance test was only 10%. In healthy test persons during the ergonovine test a shortening of Q-1, a decrease of the quotient PEP/LVET and a prolongation of LVETI were established. Apart from this, in patients with coronary heart disease also shortenings of ICT and PEP and an increase of the quotient LVET/S1S2 were made evident. During the cold tolerance test in healthy test persons, besides the prolongation of LVETI, no other changes were stated. On the other hand, in the patients a decrease of the quotient PEP/LVET and a shortening of PEP were existing. The diagnostic value of the analysis of the left-ventricular time intervals was insignificantly higher during the ergonovine test than at rest. However, during the cold pressure tests no differences were stated. The application of the analysis of the left-ventricular time intervals does not essentially enlarge the sensitiveness of the two tests in comparison to the analysis of the changes of the ST segment in the ECG.

Angina Pectoris, Variant↗
PubMed1988

[The significance of systolic time intervals in the dipyridamole test for the diagnosis of coronary disease].

The investigations concerning the significance of the systolic time intervals in the dipyridamole test for the diagnosis of the coronary heart disease were carried out in 15 healthy test persons and 40 patients with coronary heart disease. Apart from the systolic time intervals calculated according to Weissler and co-workers also the behaviour of the ST segment, the R wave in lead V5 (RV5) and the sum of the amplitudes of the R waves (sigma R) were estimated concerning sensitivity, specifity and predictive value. At a sensitivity of 65% for the behaviour of the ST segment under influence of the dipyridamole test this was smaller for RV 5, sigma R, ICT and LVET/S1S2, on the other hand greater for PEPI and OS2I (p less than 0.05). The other time intervals did not differ in their sensitivity to the ST segment. The specifity and the predictive confirming value were 100% for the changes of the ST segment. In the analysis of the other parameters no differences were stated (p greater than 0.05). The predictive value, excluding a coronary heart disease, was 51.7% for the ST segment and still higher for PEPI and OS2I (p less than 0.05). By the analysis of the systolic time intervals the diagnosis value of the dipyridamole test continues to increase.

Adult↗
PubMed1988

[The effect of naloxone on basal and maximum gastric secretion in patients with chronic duodenal ulcer].

In 22 men with chronic duodenal ulcer and 15 healthy men effect of a single intravenous injection of 2 mg of naloxone on basis and pentagastrin-stimulated acid output was determined. Naloxone was found to induce a significant decrease in BAO in chronic duodenal ulcer patients; a decrease in BAO in healthy men was insignificant. MAO was not affected by naloxone in both groups. Gastric secretions of potassium, sodium, chloride and mucoprotein were proportional to changes in the volume of the gastric juice. It seems that opioid agonists may play some role in the pathogenesis of duodenal ulcers.

Acid-Base Equilibrium↗
PubMed1988

[Maximal gastric secretion during physical exertion and restitution in patients with chronic duodenal ulcer].

The purpose of this work was determination of the effect of physical exercise on maximal gastric output. The study was carried out in 21 men aged 20-56 years with chronic duodenal ulcer. The control group comprised 17 healthy men aged 20-28 years. During three successive hours the maximal acid output was determined at rest, during one-hour exercise on a cycle ergometer and during one-hour restitution. Gastric secretion was stimulated with pentagastrin administered subcutaneously in a dose of 6 mcg/kg at the beginning of each hour of the study. Besides that the parameters of acid-base equilibrium were determined before the beginning of resting MAO measurement, immediately after its completion, and then after one hour of exercise and one hour of restitution. Physical exercise caused in the group of patients a significant increase of MAO (p less than 0.001), which was due to increased volume of gastric juice (p less than 0.001) and the concentration of acid in it (p less than 0.02). During the restitution the value of MAO was significantly below that obtained at rest. On the other hand, in healthy subjects exercise caused a significant reduction of MAO value (p less than 0.005) as a result of decreased volume of gastric juice (p less than 0.005). During MAO determination at rest a rise was observed in the pH of blood, increased concentration of bicarbonates and base excess (p less than 0.05). During the exercise with further aspiration of gastric juice a further significant increase of pH and pO2 and reduction of pCO2 (p less than 0.05) was observed. Exercise caused in patients an increase of gastric secretion in contrast to healthy subjects. Changes in acid-base balance showed a tendency for metabolic alkalosis with hypocapnia, and were similar in both groups.

Adult↗
PubMed1987

Effect of exercise on left-ventricular systolic time intervals in patients with coronary heart disease.

Left-ventricular systolic time intervals measured at rest and after submaximal exercise were analysed in 156 patients with positive exercise test results and in 219 healthy volunteers with negative exercise test results. The patients were suffering with high probability, from coronary heart disease. The healthy subjects as well as the patients were divided into five groups on the basis of the submaximal exercise loads tolerated by them. Load of 30 W was taken as starting point. At rest, the patients had shorter ejection times (LVET) and total electromechanical systolic times (QS2), and longer preejection periods (PEP) and isovolumetric contraction times (ICT), than the healthy subjects. The PEP/LVET ratio for the patients was higher than that for the healthy subjects. In groups of the same tolerance to work, exercise induced less pronounced decreases in PEP and PEP/LVET values and more pronounced decreases in QS2 and LVET values in the patients than in the healthy subjects.

Adult↗
PubMed1986

[Dynamics of left ventricular systole in primary arterial hypertension with a positive submaximal stress test].

There was made an exercise test until appearing exercise limiting symptoms in 50 patients with the second period of primary arterial hypertension (PAH) and in 73 healthy subjects. Exercise test was positive in 26 PHA patients (group I), and was negative in 24 (group II). Negative exercise tests were stated also in a group of 73 healthy subjects (control group-III). Tolerance of physical exercise, probability of coronary heart disease, rest and exercise arterial blood pressure values and left-ventricular systolic time intervals (LVSTI) were analysed in these groups. The preejection period (PEP) and PEP/LVET ratio increased and left-ventricular ejection time index (LVETI) decreased at rest in patients with the second period of PAH as compared in healthy subjects. It proved that left-ventricular mechanical function had been damaged. Submaximal physical exercise proceeded however with similar changes of LVSTI as healthy subjects. There were found high pretest probability of coronary heart disease, decreased tolerance of submaximal physical effort and decreased left-ventricular mechanical function in patients with positive exercise test. Rest values of PEPI and PEP/LVET ratio were significantly higher and LVETI were lower in I than in II (p less than 0.05) an in III group (p less than 0.001). Increased values of PEPI, LVETI and PEP/LVET ratio in relation to the second group and much more as compared in the control group were observed during physical effort.

Blood Pressure↗
PubMed1985

Changes in the interleukin-1 and interleukin-2 generation in duodenal ulcer patients during cimetidine treatment.

The effect of cimetidine treatment on the generation of interleukin-1 (IL-1) and interleukin-2 (IL-2) was studied in 11 duodenal ulcer patients. The results obtained were compared with those for untreated healthy subjects. The drug was administered intravenously in a dose of 200 mg four times a day for 8 days. The investigations were performed before, during and 1 wk after cimetidine therapy. IL-1 generation was determined by the ability of supernatants from 2-day cultured adherent cells stimulated by lipopolysaccharide to enhance proliferation of PHA-stimulated mice thymocytes. IL-2 generation was determined by the ability of supernatants from 2-day cultured, PHA-stimulated mononuclear cells to proliferate autologous 17-day cultured T cells. In all ulcer patients IL-1 generation diminished during cimetidine treatment (P less than 0.005). It continued to decrease in 4 subjects and increased in the other 7 ones following drug withdrawal. All the values were higher than those in healthy controls. IL-2 activity in ulcer patients was similar to that in healthy subjects and it increased significantly in all ulcer patients following the onset of the treatment (P less than 0.005) and decreased nearly to the initial values 1 wk after termination of the treatment (P less than 0.005). The present studies indicate that cimetidine, a selective histamine H2-receptor antagonist, deeply changes mechanisms of immunoregulation in patients with duodenal peptic ulcer.

Adult↗