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Biomedical subjects

K Markiewicz

Publications and source records attributed to K Markiewicz.

At least 55 records · Page 3Linked to original sources
PubMed1985

[Clinical characteristics of forms of chronic hepatitis].

Chronic hepatitis is now the general problem in hepatology. The diagnosis of this disease remains difficult in spite of continuous development of diagnostic methods. 57 patients (25 female and 32 male) with chronic hepatitis were studied. They were divided in three groups (I - chronic active hepatitis, II - chronic persisting hepatitis, III - chronic reactive hepatitis) according to the result of the liver biopsy. The clinical data (from medical examination and laboratory analysis) in the respective forms of chronic hepatitis were compared. The analysis of 14 subjective and objective symptoms in this three groups of patients has shown the certain differences between them. It may play a role in the diagnosis of the form of chronic hepatitis.

Adolescent↗
PubMed1985

[Effect of cimetidine on maximal stomach secretion in physical stress and at rest in patients with chronic duodenal ulcer].

In 21 males suffering from chronic duodenal ulcers the effect of cimetidine on the maximum acid output (MAO) both in rest and under physical load was examined. Patients were loaded two times (60 min) with the Monark bicycle ergometer at an interval of 5-7 days. Immediately before second examination cimetidine was injected intravenously (6 mg/kg body weight). The sampling of gastric juice was done 3 times for 60 min before, during and after the physical work. In the stimulated gastric fluid the concentrations of sodium, potassium, chlorid ions, total protein and mucoproteins were checked. In the peripheral venous blood sodium, potassium, chlorid, magnesium and calcium were measured as well as glucose and the parameters of acid base state. Cimetidine significantly reduced ionic concentration, protein and mucoproteid concentrations of the gastric fluid. Cimetidine did not provoke any changes of the parameters determined in the peripheral blood.

Adult↗
PubMed1985

Phagocytic and bactericidal activities of neutrophils in duodenal ulcer patients during cimetidine treatment.

Phagocytic and bactericidal activities of neutrophils relative to Staphylococcus aureus 209 P strain were studied in 16 duodenal ulcer patients who were intravenously administered cimetidine in doses of 4 X 200 mg for 8 days and in a group of untreated healthy subjects. The investigations were made before the treatment on the last day of cimetidine administration, and one week after drug withdrawal. The bactericidal activity of neutrophils was found to be higher in duodenal ulcer patients than in the healthy controls. Cimetidine does not have a significant effect on the phagocytic activity of neutrophils and it has a moderately inhibitory effect (p less than 0.05) on the bactericidal activity relative to the ingested intracellular bacteria. This shows that cimetidine may modify some of the neutrophil functions in duodenal ulcer patients.

Adult↗
PubMed1985

Post-exertion changes in left ventricular systolic time intervals in patients with primary hypertension treated with hydrochlorothiazide, binazine, and propranolol.

The study involved 13 patients with primary hypertension who exercised on a bicycle ergometer with intensity increasing up to submaximum level. The exercise was carried out in four stages: before treatment (1st study), following one week treatment with 50 mg hydrochlorothiazide daily (2nd study), after one week treatment with the same dose of hydrochlorothiazide and 120 mg binazine daily (3rd study), and after one week treatment with hydrochlorothiazide and binazine, and 60 mg of propranolol daily (4th study). Using the approach of Weissler et al., left ventricular systolic time intervals were analysed at rest, after exercise and up to the 90th minute of restitution. Hydrochlorothiazide and binazine treatment decreased systolic and diastolic blood pressure, the total electromechanical systolic time index (QS2I) and the left ventricular ejection time index (LVETI), and increased the PEP/LVET index at rest and after exercise. Addition of propranolol did not augment the hypotensive effect, while the left ventricular systolic time intervals returned to the values observed before treatment.

Adult↗
PubMed1984

The effect of cimetidine treatment on suppressor T cells in duodenal ulcer patients.

Changes in the suppressor T-lymphocyte activity were studied in 11 patients with duodenal ulcer during treatment with cimetidine. The drug was administered intravenously in a dose of 200 mg four times a day for a fortnight. Suppressor T-cell activity was determined by the Shou et al. method using two-stage culture before treatment, after 4 days of the treatment, just before drug withdrawal, and 2 days and 2 wk after the treatment. Suppressor T-cell activity significantly decreased soon after starting the treatment, remained low throughout the treatment, and rapidly and significantly increased following drug withdrawal.

Adult↗
PubMed1983

Effect of blood loss on the plasma level of whole peptides and their fractions at rest and during exertion and restitution.

The plasma level of peptides and their fractions was investigated in 12 male voluntary blood donors aged 19-23 years at rest, during exercise and restitution before and 1 and 24 h after blood withdrawal. In each test the subjects exercised on Monark's cycle ergometer under loads producing a heart rate acceleration up to 170/min (Physical Working Capacity -- PWC 170). Blood loss produced a non-significant decrease in the plasma peptide level. During exercise the levels increased significantly both before (P less than 0.001) as well as 1 h and 24 h after blood loss (P less than 0.025). About one half of the increase was due to haemoconcentration. During restitution the levels were not significantly different from the initial values. Blood loss gave rise to a significant increase in the level of fractions of a molecular weight exceeding 3500 while the concentration of fractions of 1500-3500 molecular weight decreased. The changes in the peptide fractions were slightly different in the case of exercise performed after blood loss from those observed before blood loss. This applies first of all to fractions with a molecular weight below 750 whose concentration decreased during exercise performed after, and increased before, blood loss.

Adult↗
PubMed1983

Effect of blood withdrawal on the left ventricular systolic time intervals at rest and during prolonged recovery following submaximal exercise.

0.40 1 of full blood were withdrawn from 18 males aged 19-23. One day before withdrawal, one hour and 24 h after withdrawal the subjects performed a 10-min exercise on a Monark bicycle ergometer with a load producing heart rate acceleration up to 170/min. At rest and in the course of 120-min post-exercise recovery ventricular systolic time intervals were investigated using the method of Weissler. Immediately after blood withdrawal and one hour later the authors observed a decreased left ventricular ejection time index (LVETI), increased pre-ejection period (PEP), and increased isovolumetric contraction time (ICT), as well as increased PEP/LVET ratio. In the course of recovery following exercise performed one hour after withdrawal the LVET value was lower, and the values of PEP, ICT and PEP/LVET ratio higher than those obtained after identical exercise performed before withdrawal.

Adult↗