Effect of albumin on diffusion rates of basic peptides across semipermeable membrane.
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Biomedical subjects
Publications and source records attributed to K Markiewicz.
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In 30 healthy men, aged 20-24 years, the effect of physical exercise on the concentration of Na and K in serum erythrocyte and whole blood, on the serum chloride concentration and on capillary blood acid-base equilibrium was studied (Group A). In another group of 20 men the same studies were performed after smoking of 4 cigarettes (Group B). Taking into consideration blood condensation plasma Na, K and Cl concentrations were found to be decreased significantly (p less than 0.05). Sodium concentration in erythrocytes increased significantly after exericse in group B as compared with group A (p less than 0.01). Similarly, potassium concentration in erythrocyte increased significantly 30 minutes after exercise in group B as compared with group A (p less than 0.005). There were no differences in changes in acid-base equilibrium after exercise between both groups--they indicated the shift towards metabolic acidosis.
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The clinical course of acute poisoning with carbon tetrachloride in 13 patients is presented. The treatment with corticosteroids has been beneficial, particularly in cases with considerable damage of the liver. The extracorporal dialysis allowed to survive the period of heavy uraemia.
Behaviour of basal gastric secretion of electrolytes, lactic acid and pyruvic acid was studied in twenty-minute portions in 14 healthy men in rest, during exercise and restitution. On bicycle ergometer in sitting position all studied men performed the average work 15 120 +/- 1800 kpm during 20 minutes. It was found that basic gastric secretion didn't change significantly during exercise, but its significant decrease occurred during twenty-minute restitution after exercise. During restitution secretion of Cl, Mg and Ca also significantly decreased while their concentrations didn't change in gastric juice. During physical exercise it was found the increase of lactic acid secretion in gastric juice; it was statistically significantly higher during restitution than in rest period (p less than 0.001) and during exercise (p less than 0.02).
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The influence of a single intravenous glucose load on maximal gastric acid secretion in 25 healthy men when stimulated with pentagastrin was studied. Under the influence of hyperglycaemia, a highly significant decrease of maximal acid output was found. Moreover, in the gastric juice an increase of chloride and calcium concentrations was noted. On the other hand, the output of potassium, chloride and magnesium was lowered. The above differences were statistically significant.
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