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Biomedical subjects

K Mees

Publications and source records attributed to K Mees.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Personal catheter technic for intra-arterial chemotherapy in cancers of the head and neck].

Regional intraarterial chemotherapy can display its advantages as augmented concentrations of effective substances within the tumour tissue and lower systemic side effects, only if tumour perfusion can be carried out superselectively. For different reasons, the present techniques have not been accepted for extensive clinical use. A new catheter technique is, therefore, presented that is appropriate for both clinical routine and superselective tumour perfusion.

Antineoplastic Agents↗
PubMed1987

[Diagnostic value of nuclear magnetic resonance tomography in space occupying lesions of the pharynx].

The diagnostic value of CT in tumours of the pharynx is limited due to the reduced soft tissue contrast of this method. In the present study we report on our own experience with MR imaging of this area. We could demonstrate that MR possesses an increasing importance in the diagnosis of tumours of the head and neck. This is mainly due to the better soft tissue contrast which can even be improved by using the paramagnetic contrast medium Gd-DTPA in certain cases.

Gadolinium↗
PubMed1987

[Microsurgical reconstruction of large 3-layer defects of the cheek].

For reconstruction of large penetrating defects of the cheek besides pedicled tissue transfer numerous free flaps are available to the head and neck surgeon. The inferior epigastric abdominal wall flap, in particular, has proved a versatile and reliable flap, just as the cutaneous flaps from the dorsum of the foot and from the forearm. While the abdominal wall flap offers both, a cutaneous and a peritoneal surface, the latter is used for replacement of intra-oral lining, the cutaneous flaps have to be folded to obtain two surfaces for reconstruction of skin and intra-oral lining. The surgical technique of the epigastric abdominal wall flap is presented and its use is discussed.

Carotid Artery, External↗
PubMed1986

[Magnetic resonance tomography in suspected acoustic neurinoma: technic and differential diagnosis].

Sixty-five patients with suspected acoustic neuromas were examined by CT and MR; the optimal diagnostic procedures are discussed. Extrameatal acoustic neuromas (11 cases) were all diagnosed by CT and MR, but only 82% of intrameatal tumours could be diagnosed by CT combined with air cisternography. Using special surface coils and the paramagnetic contrast medium Gd-DTPA, the accuracy of MR was 100%. All tumours greater than 4 mm were demonstrated. Following clinical and neurological examination, MR is the primary diagnostic method in the investigation of acoustic neuromas.

Diagnosis, Differential↗
PubMed1986

[Nuclear magnetic resonance diagnosis of tumors of the internal auditory canal and the cerebellopontile angle].

The diagnosis of acoustic neuromas has been continually improving. By means of gas cisternography used additionally, intracanalicular neuromas can be imaged indirectly. However, these procedures lead to a certain degree to both false positive and false negative results. With MRI, as the latest imaging technique, it is always possible to detect early stages of intracanalicular growth. When using a surface coil spatial resolution will be less than 1 mm. Our experience with this imaging technique in the diagnosis of tumours of the inner ear canal and the cerebellopontine angle is discussed and our indications for the use of MRI are presented.

Cerebellar Neoplasms↗
PubMed1986

[Adverse effects of drugs on the hearing organ].

Many different classes of drugs are known to produce ototoxicity. They include such commonly used agents as salicylates and diuretics but the most important of them are the ototoxic antibiotics, particularly those of the aminoglycoside group. The toxic effects result from an initial selective damaging to the organ of Corti (hair cells) or the secretory cells of the stria vascularis. Both damaging mechanisms are dose-dependent. The ototoxic risk of the different drugs is described.

Aminoglycosides↗
PubMed1985

[Diagnostic value of cervical lymph node biopsy in suspected nasopharyngeal cancer].

More than 90% of nasopharyngeal malignancies are carcinomas. Early symptoms are rare and usually ignored by the patients. The most common symptoms present are enlarged cervical nodes. More than half of all patients with nasopharyngeal carcinoma (58%) treated in the ENT-Clinic of the University of Munich had been admitted for further investigation because of cervical lymph node enlargement. Enlarged cervical lymph nodes can be removed easily. Thus the value of a lymph node biopsy for early diagnosis of nasopharyngeal carcinoma was examined. Forty-five cases of occult nasopharyngeal carcinomas have been reviewed. In all cases a cervical lymph node had been removed as a first diagnostic procedure. The histological findings were compared to nasopharyngeal biopsies taken after different time intervals. Our clinico-pathological review has shown that, especially in undifferentiated carcinoma, the histological features of cervical metastases is always identical to the very characteristic primary lesions in the nasopharynx. Thus, the characteristic feature of this tumour type in a jugulo-digastric lymph node strongly suggests the presence of a primary nasopharyngeal carcinoma.

Biopsy↗
PubMed1985

[Computer or conventional tomography? Comparative studies in craniofacial fractures].

Both conventional tomography and computed tomography are usefully employed in examinations of facial and frontal skull base fractures. Whereas computed tomography offers an excellent high-resolution image, conventional tomography yields a better spatial representation. The advantages and limitations of these techniques in the diagnosis of facial and frontal skull base fractures are presented and discussed.

Facial Bones↗
PubMed1985

[Invasive aspergillosis of the head and neck].

Aspergillosis of the paranasal sinuses after invasion of the neighbouring orbit and/or the sella turcica may simulate a malignant tumour. Exploratory excisions usually lead to the diagnosis of a chronic sinusitis. With the aid of special staining methods as well as cultural and serological tests the diagnosis of an aspergilloma can be established.

Adult↗
PubMed1984

Glycerol effects on the transport of macromolecules in the lateral cochlear wall. An HRP study in the guinea pig.

The effect has been studied of intravenously administered glycerol on paracellular and cellular transport of macromolecular HRP tracer in the lateral cochlear wall. The findings indicate osmotically induced diffusion phenomena by the opening of shunt pathways through junctional complexes in the stria vascularis. Vesicular transport is accelerated, direction of transport however is not affected by the changed osmolality.

Animals↗
PubMed1984

Cytochemical localization of adenylcyclase in the lateral wall of the inner ear.

The cytochemical localization of adenylcyclase in the lateral cochlear wall was studied using a modification of the Reik -Howell method. All the cell membranes of the stria vascularis and spiral prominence cells, except the vascular endothelium, showed a low enzyme activity. In the marginal cell and spiral prominence epithelium facing the endolymph, this activity was limited to the perilymphatic membrane sections. The results are discussed.

Adenylyl Cyclases↗
PubMed1984

[Nuclear magnetic tomography in cervical lymph node swellings].

Magnetic Resonance Imaging (MRI) and CT were performed in a patient suffering from carcinoma of the larynx with swollen cervical lymph nodes. MRI images in coronal planes give new diagnostic information about the spatial extension of pathologic findings and about the question of compression or infiltration of vessels. Exact topographic knowledge will be necessary. A subject of research is the differentiation between scar formation and tumour relapses.

Aged↗
PubMed1984

[Nuclear magnetic tomography in otorhinolaryngology. Case reports].

Magnetic resonance imaging (MRI) promises the achievement of considerable improvements in diagnostic procedures in otorhinolaryngology. In this article, the advantages of the technique are presented and their significance in diagnosis of head and neck disorders is discussed. An important advantage is the fine and detailed representation of tumours particularly in the soft tissue of the neck and the base of the tongue, which is made possible by an enhancement of contrast and by the improved spatial imaging based on the frontal and sagittal projection plane. MRI also seems to provide a new approach to the diagnosis of tumours of the glomus jugulare and the carotid body and of acoustic neurinomas. Besides, it will be possible to obtain more detailed information on the depth of infiltration of laryngeal carcinomas with the aid of surface coils.

Diagnosis, Differential↗
PubMed1984

[Hormonal control of the inner ear. Fiction or reality?].

The aetiology of numerous functional disorders of the inner ear is still unknown. In particular, it is unclear whether these hearing disorders are a result of a primary damage to the sensory or secretory epithelium, or perhaps a result of a disturbed cochlear control mechanism. In the kidney, ion transport is controlled by hormonal influence mediated by an adenylate cyclase mechanism. Adenylate cyclase has been localized biochemically and cytochemically in the inner ear. Its activity can be increased with vasopressin and parathormone. Thus the question has been raised whether cellular metabolism and transport in the inner ear is indeed controlled by hormonal influence. The results of the electronmicroscopic-cytochemical localization studies of adenylate cyclase in the lateral wall of the cochlea and in the endolymphatic sac are presented, and their possible physiological significance is discussed.

Adenylyl Cyclases↗