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Biomedical subjects

K Nakago

Publications and source records attributed to K Nakago.

17 recordsLinked to original sources
PubMed1999

Simultaneous fracture-dislocations of the distal and proximal interphalangeal joints.

Sixteen cases of simultaneous fracture-dislocations of both the distal interphalangeal (DIP) and proximal interphalangeal (PIP) joints in the same finger that were treated during the past 10 years were classified into three types: the swan-neck injury (dorsal fragment of the base of the distal phalanx at the DIP joint and palmar fragment of the base of the middle phalanx at the PIP joint); the double-hyperextension injury (palmar fragments at the DIP and PIP joints); and the straight-finger injury (with dorsal and palmar bone fragments at the DIP joint). The results of treatment were more satisfactory in PIP joints than in DIP joints.

Adolescent↗
PubMed1999

Influence of exercise on muscle fibers in rats with steroid myopathy.

The influence of mild exercise on skeletal muscle fibers was investigated histochemically to assess the effects of exercise on steroid myopathy and its efficacy for preventing this disease. Twenty male Wistar rats were divided into 4 groups of 5 each: group T, which received exercise alone; group S which received steroid alone; group ST which received both exercise and steroid; and group C, the control group. In groups S and ST, hydrocortisone was administered subcutaneously at a dose of 10 mg/kg/day for 4 weeks. In the exercise groups, the animals were made to run at a speed of 15 m/min for about 1 h/day for 5 days a week on a treadmill. After the completion of treadmill exercise and steroid administration for 4 weeks, the rats were anesthetized with Nembutal, the soleus muscle (SOL) and the extensor digitorum longus muscle (EDL) were removed and prepared for examinations. The area of type I fibers in the SOL was significantly larger in group ST than in group S. The area of type IIa fibers in the EDL was significantly larger in group ST than in group S. In group S, the proportion of type I fibers in the SOL was significantly lower than in the other three groups. There was little difference in fiber type distribution between groups ST and C. These results suggest that steroid myopathy can be prevented by even mild exercise.

Animals↗
PubMed1997

[A case of transient cortical blindness due to reversible ischemic neurological deficit (RIND) after caesarean section under lumbar anesthesia].

We report a case of 31-year-old woman with pregnant toxicosis, who developed transient blindness after caesarean section under lumbar anesthesia. The patient was hypoxic due to atelectasis when she developed blindness, but she had no ophthalmologic abnormalities. MRI depicted abnormal high intensity areas (HIA) with T 2-weighted images (T 2 WI) in the occipital lobes and the basal ganglia. CT could not detect any of these MRI findings. The patient regained her vision four days after the onset. The HIA disappeared in a follow up MRI (T 2 WI) two weeks after the onset. The patient was diagnosed as cortical blindness due to RIND. Although most of the transient cortical blindness are accompanied with pregnant toxicosis with hypertension, there are some cases without pregnant toxicosis. We stress the importance of maintaining the blood pressure within the normal range in patients with hypertension who undergo surgery under spinal anesthesia.

Adult↗
PubMed1996

Muscle fiber changes of the vastus medialis in rheumatoid patients.

To study the pathology of muscle atrophy in rheumatoid arthritis (RA), we examined the vastus medialis in rheumatoid patients histologically. The relationship of the findings to their ambulatory ability and long-term steroid therapy was investigated. The muscles of the RA patients were also compared with those of patients with osteoarthritis (OA). Specimens of the vastus medialis were collected from 29 knees of 23 patients with RA and 16 knees of 13 patients with OA during total knee arthroplasty. Muscle fibers were classified according to their type, and the ratio between the area of single type I and type II fibers as well as the ratio between the total area of these fibers was calculated. The total area of type II fibers in the RA group was significantly greater than in the OA group (P < 0.05). In the RA group, the mean proportion of the type II fibers relative to the total muscle fiber area tended to increase with the decline of ambulatory ability, while there was no such increase in the OA group. The proportion of type II fibers was increased significantly in RA patients on long-term steroid therapy when compared to those without therapy. In the ratio of the area of a single fiber, there was no clear relationship to ambulatory ability and long-term steroid therapy. It is considered that muscle atrophy in RA is not solely disuse atrophy, but also has a close relationship to steroid therapy and the pathology of the disease itself.

Aged↗
PubMed1986

An autoradiographic study of changes in the uptake of tritiated estradiol in the anterior hypothalamus during the estrous cycle of the rat.

In cycling rats exposed to a controlled light schedule of 12 h of light daily from 22.00 to 10.00 h the concentration of estradiol in the anterior hypothalamus at 5.00-6.00 h on the day of proestrus was significantly higher than those at 0.00-1.00 h on day 1 of diestrus and estrus, and was about twofold higher than serum estradiol concentration, which reached a peak at 5.00-6.00 h on the same day. Autoradiographically, the uptake of tritiated estradiol by the nuclei of neurons in the nucleus (n.) preopticus, pars suprachiasmatica (POSC), n. preopticus periventricularis (POP), and anterior part of n. anterior hypothalami (AAH) was significantly higher at 1.00 h on the day of diestrus 1 than at 6.00 h on the day of proestrus and at 1.00 h on the day of estrus. These results suggest that the POSC, POP and AAH may be target sites in the anterior hypothalamus of estradiol for its feedback action.

Animals↗
PubMed1985

Retardation in gonadotropin-secreting function of the pituitary during the early puerperium in women with postpartum hemorrhage but without circulatory collapse.

Recovery of gonadotropin-secreting function of the pituitary during the early puerperium has been studied in women with postpartum hemorrhage of 500 g and more during the first 2 h after expulsion of the placenta but without circulatory collapse. On day 4 postpartum, the concentrations of erythrocytes, hemoglobin, and hematocrit were significantly lower in puerperal women with postpartum hemorrhage than in normal puerperal women. On day 20 postpartum, administration of 100 micrograms synthetic luteinizing hormone-releasing hormone (LHRH) significantly increased serum follicle-stimulating hormone (FSH), but not luteinizing hormone, in puerperal women with severe postpartum hemorrhage of more than 1,000 g, but the FSH response to LHRH was significantly lower in these women than in normal women on the same postpartum day. All puerperal women were lactating and there was no significant difference in serum prolactin levels between normal puerperal women and puerperal women with postpartum hemorrhage. These results indicate that blood loss in the amount of more than 1,000 g during the first 2 h after expulsion of the placenta may cause perturbation to some extent in recovery of gonadotropin-secreting function of the pituitary during the early puerperium, even if there are no complications by circulatory collapse and disabled lactation.

Adult↗
PubMed1984

Hypothalamic function in women during the first month post-partum.

Plasma LRH-immunoreactive substance in puerperal women was very low on days 5 and 10 post-partum and significantly increased between days 10 and 20 post-partum, but remained at a similar level on day 30 post-partum, which was significantly lower than that in eumenorrhoeic women on day 8 or 9 of the normal cycle. Although LRH administration did not significantly increase serum FSH on day 11 post-partum, daily injections of LRH from days 5 through 10 post-partum caused a significantly increased secretion of FSH on day 11 post-partum, both basally and in response to LRH. No significant difference was observed in serum oestradiol and Prl levels on day 11 post-partum between the two groups of women with and without LRH pre-treatment. It is concluded that the amount of hypothalamic LRH secretion may be small during the first month post-partum, and low basal FSH and unresponsiveness of the pituitary to LRH observed in the early puerperium may result from hypothalamic hypofunction.

Estradiol↗
PubMed1984

[Recovery of gonadotropin-secreting function of the pituitary in the puerperal women with eclampsia].

Recovery of gonadotropin-secreting function of the pituitary has been studied in 4 puerperal women with episodes of eclampsia during the last pregnancy, delivery and/or the first 24 hours after delivery. On day 20 postpartum, hypertension, edema and proteinuria were improved in all the puerperal women. Serum FSH and LH responses to LH-RH on day 20 postpartum in 3 puerperal women with less than 6 eclamptic attacks during pregnancy or delivery were at a comparable level to those on day 20 postpartum in 4 puerperal women with premature labor between 31 and 33 weeks' gestation and in 9 normal puerperal women. Serum FSH response to LH-RH on day 20 postpartum in a puerperal woman with 10 eclamptic attacks during pregnancy and the first 24 hours after delivery was lower than those in 4 puerperal women with premature labor and in 9 normal puerperal women. In the puerperal woman with 10 eclamptic attacks, the lowered FSH response to LH-RH on day 20 postpartum was apparently improved on day 55 postpartum. However, the FSH response to LH-RH on day 55 postpartum was still lower in the puerperal woman with 10 eclamptic attacks than in 7 normal puerperal women. These results indicate that many eclamptic attacks during pregnancy, delivery and/or the first 24 hours after delivery may cause perturbation to some extent in recovery of FSH-secreting function of the pituitary during the puerperium.

Adult↗
PubMed1984

[Hypothalamic-pituitary function in women after abortion or premature labor].

Hypothalamic function during pregnancy and hypothalamic-pituitary function during the first month after abortion or premature labor have been studied. The plasma LH-RH level in pregnant women was significantly lower between 18 and 23 weeks' gestation than that in eumenorrheic women on day 8 or 9 of the normal cycle, and thereafter decreased until term. Serum FSH showed normal response to LH-RH on day 10 after pregnancy termination between 5 and 23 weeks' gestation, but no FSH response to LH-RH was found on day 10 after premature labor at 33 weeks' gestation. Serum FSH responded normally to LH-RH on day 30 after pregnancy termination at 18 weeks' gestation, but serum FSH responded excessively to LH-RH on day 30 after premature labor at 30 weeks' gestation. The positive feedback effect of estrogen on LH release was not operative on day 30 after pregnancy termination beyond 18 weeks' gestation, though it was operative on day 30 after pregnancy termination between 6 and 11 weeks' gestation. These results indicate that the duration of pregnancy has an influence on the recovery of hypothalamic-pituitary function after pregnancy termination and that the recovery of hypothalamic-pituitary function during the first month after premature labor beyond 30 weeks' gestation is similar to that after normal labor.

Abortion, Induced↗
PubMed1983

Reproductive function following advanced ovulation induced by synthetic luteinizing hormone-releasing hormone in rats.

Reproductive function following advanced ovulation induced by a single injection of 1 microgram synthetic luteinizing hormone-releasing hormone (LH-RH) has been studied in rats. While advanced ovulation induced by an injection of the agent on the day of proestrus was followed by pregnancies occurring as frequently as those in spontaneous ovulation group, incidences of mating behavior, fertilization, and pregnancy were considerably reduced in the advanced ovulation group when induced by an injection of synthetic LH-RH during the early period of diestrus 2. The mean volume of primary oocytes of the three largest follicles at 1.00 h on the day of diestrus 2 was significantly smaller than that at 1.00 h on the day of proestrus. However, shortly before ovulation, the mean volume of secondary oocytes in the preovulatory follicles from rats treated with synthetic LH-RH at 1.00 h on the day of diestrus 2 was approximately the same as that in the preovulatory follicles from rats treated with the agent at 1.00 h on the day of proestrus. Shortly after ovulation the number of mitotic cumulus cells around the oviductal ova was significantly greater in advanced ovulation group induced by synthetic LH-RH injection during the early period of diestrus 2 than in spontaneous ovulation group. Furthermore, when examined 13 h after ovulation, the layers of cumulus cells were thicker, and cumulus cells were more tightly arranged around the ova in the advanced ovulation group induced by injection of synthetic LH-RH during the early period of diestrus 2 than those in the group with with spontaneous ovulation. These results suggest that the cumulus-oocyte complex from advanced ovulation group induced by injection of synthetic LH-RH in the early period of diestrus 2 is less potent in fertilizability than that from spontaneous ovulation group, leading to a reduction in the rate of subsequent pregnancy.

Animals↗
PubMed1983

[Hypothalamic-pituitary-ovarian function in puerperal women].

Hypothalamic-pituitary-ovarian function in women during the first month postpartum has been studied. The plasma LH-RH level in puerperal women was very low on days 5 and 10 postpartum and thereafter increased, but was still significantly lower on day 30 postpartum than that in eumenorrheic women on day 8 or 9 of the normal cycle. Serum FSH reached a very low level on days 5 and 11 postpartum, then gradually increased to a slightly higher level on day 30 postpartum than that in eumenorrheic women. The serum estradiol level fell immediately after delivery and remained low until day 30 postpartum. No response of serum FSH or LH to LH-RH was found on day 11 postpartum. However, daily injections of LH-RH from days 5 through 10 postpartum caused an increased secretion in FSH on day 11 postpartum, both basally and in response to LH-RH. On day 20 postpartum, serum FSH responded excessively to LH-RH in all women, but the response in serum LH was restored in a half of them. The mean basal level of serum FSH was significantly higher in cases demonstrating the response in serum FSH and LH than that in cases demonstrating the response in only serum FSH. Serum FSH and LH showed excess and normal responses respectively to LH-RH on day 30 postpartum. It is concluded that hypothalamic secretion of LH-RH decreases during the first month postpartum, especially for the first 10 days, and the low basal level of serum FSH and unresponsiveness of the pituitary to LH-RH observed in the early puerperium may result from hypothalamic hypofunction.

Adult↗
PubMed1981

Effects of glycine on serum gonadotropins and estradiol and on concentrations of free amino acids in the middle hypothalamus in female rats.

The effects of glycine on serum gonadotropins and estradiol (E2) and on concentrations of free amino acids in the middle hypothalamus have been studied in diestrus-1 rats. 20 min after intraperitoneal administration, glycine in doses of 50 and 100 mg had no significant effect on serum luteinizing hormone (LH) levels, but 200 mg significantly elevated serum LH levels. Glycine in doses of 50-200 mg had no effect on serum follicle-stimulating hormone levels at 20 min after intraperitoneal injection. 200 mg of glycine significantly elevated serum LH levels at 20 and 50 min and serum E2 levels at 50 and 80 min after intraperitoneal injection. The effects were maximal at 20 min after injection for LH and at 50 min after injection for E2. 20 min after intraperitoneal injection, 200 mg of glycine significantly increased the concentration of glycine in the middle hypothalamus, but had no effect on the concentrations of the other free acidic and neutral amino acids in the middle hypothalamus. These results suggest that glycine may play a role in the neural regulation of LH secretion.

Amino Acids↗
PubMed1981

Dose- and age-dependent effects of clomiphene citrate administered to prepubertal female rats on development of anovulatory sterility and pyosalpinx.

The influences of dose of clomiphene and age at clomiphene treatment in prepubertal female rats on development of anovulatory sterility and pyosalpinx were investigated. By varying the amount of clomiphene administered, it was found that 50 micrograms is the minimal dose of clomiphene which will produce anovulatory sterility and pyosalpinx in a majority of female rats treated at 5 days of age. By varying the age of rats at clomiphene treatment, it was observed that the period of clomiphene sensitivity in female rats is within the first 10 days of life, in which administration of 500 micrograms clomiphene will result in subsequent anovulatory sterility and pyosalpinx. These results demonstrate that the induction of anovulatory sterility and pyosalpinx is dependent upon the dose of clomiphene and the age of rats at clomiphene injection.

Age Factors↗
PubMed1979

Anovulation and oviductal hyperplasia in rats treated with clomiphene citrate 5 days after birth.

Five day old female rats were administered either 500 micrograms clomiphene citrate or propylene glycol. Vaginal opening occurred significantly earlier in the clomiphene treated group as compared with the control group. Clomiphene treated rats showed permanent sterility associated with anovulatory vaginal cycles in which the stage of vaginal cornification predominated. Furthermore, clomiphene treated rats exhibited a high incidence of pyosalpinx (or oviductal abscess). The possible mechanisms responsible for the anovulatory sterility and the pyosalpinx induced by neonatal clomiphene treatment are discussed.

Animals↗