Biomedical subjects
Publications and source records attributed to K P Schmidt.
Rubidium (Rb+) has an antidepressive effect and shortens the circadian period in animals, whereas Li+, another alcalic metal, lengthens it. When we treated a depressive Li+ nonresponder with Rb+, we found an improvement of depression as well as a phase advance of the temperature rhythm in relation to the rest-activity rhythm.
Dose distributions of a combination from telecobalt-arc-therapy and afterloading-therapy for radiation therapy of gynecological cancers were calculated, using a computer program developed in our institute. Taking as a basis CT-scans the bone structures were taken into consideration like inhomogeneities. Conclusions about the individual dose on sensitive organs into the irradiated area like bladder and rectum become possible. The influence of changing parameters such like distance of axis of arc-therapy can be shown clearly.
For use in afterloading therapy there was constructed a special combination consisting of X-ray multiplier and a gynaecological table. Because of the constant magnification of radiographs topometric examinations became easier. Examining the displacement of points of interest when the patient is restored from a lithotomic position into a position with stretched legs we concluded that from the point of view of treatment planning it will be necessary to carry out afterloading irradiation with stretched legs like in the teletherapy. Only in such a way it is possible to calculate a common dose distribution of teletherapy and afterloading therapy.
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A method is described for direct analysis of iron in proteins. The organic and inorganic matrices can be removed during the ashing step. The results obtained with simple aqueous standards were confirmed for all determinations by the standard addition method. The interpretation of the results by means of regression analysis showed, in dependence on the biological material (Haemoglobin, suspension of Microsomes, Cytochrome P 450), relative standard deviations between 4 and 20%.
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