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Biomedical subjects

K Patai

Publications and source records attributed to K Patai.

At least 19 recordsLinked to original sources
PubMed1998

[Severe genital mycoplasma infection following cesarean section].

Authors report a serious case of post-caesarean delivery endometritis caused, probably exclusively, by genital mycoplasmas: Ureaplasma urealyticum and Mycoplasma hominis. The initial treatment of the patient with various penicillins, ceftriaxone, gentamicin, metronidazole and nystatine proved ineffective. Subsequently, as microbiological tests turned out positive for genital mycoplasmas, a therapy of doxycyclin was introduced and a full recovery could be attained. Authors' experience is consistent with the observation of American scientists that U. urealyticum is an important pathogen in post-caesarean delivery endometritis. Since the carriage of U. urealyticum in women is frequent in Hungary, it is suggested that microbiological investigations related to sectio caesarea always include tests for genital mycoplasmas.

Adolescent↗
PubMed1998

Characterization of calcified deposits on contraceptive intrauterine devices.

The formation of calcified deposits on > 200 contraceptive intrauterine devices (IUD) was quantitated as a function of time in healthy women, pregnant women, and women with a pathologic lesion. The incrustment formation was significantly enhanced when inflammation occurred, but change could not be observed in cases of pregnancy. The incrustments were analyzed by x-ray diffraction, infrared spectroscopy, x-ray microprobe, and ultramicrochemical stone analysis techniques. Major components and their average w/w percent quantities in the incrustments are as follows: calcium carbonate 75%, apatite 5%, and organic matrix 20%. Earlier hypotheses on the chemical processes of deposit formation are discussed, and a new, ionic mechanism of calcification on IUD surfaces is suggested.

Calcinosis↗
PubMed1991

[Successful pregnancy after surgery for hypophyseal microadenoma].

The authors report on a successful conception, development of pregnancy and lasting symptom-free post-partum state of a young female patient who has been operated previously because of an hypophysis microadenoma. Delivery ended with Cesarean section. A living and mature newborn was born, with a weight of 2900 g.

Adult↗
PubMed1991

Cytochemical study on the local tissue effect of nickel-containing intrauterine device in rabbits.

Authors introduced a nickel-containing device into the uterus of 20 rabbits, then performed the cytochemical study of the endometrium. During calcium cytochemical study in the endometrium intramitochondrial and partly intracytoplasmic localisation while with dimethylglyoxin method intracellular reaction precipitate were found. The nickel-containing device caused local nickel and intracellular or intramitochondrial calcium accumulation.

Animals↗
PubMed1991

Sonographic scan of the normal and pathological endometrium.

The cycle-dependent sonographic signs of the endometrium in healthy women, the morphological picture of the endometrium in the menopause as well as in tumorous changes are reviewed. The importance of sonography is pointed out in screening the pathological changes of the endometrium. The examination of the endometrium may provide useful supplementary data also to treating infertile patients. Transvaginal sonography may essentially enhance the precision of the method.

Adenocarcinoma↗
PubMed1991

Experience with a new combined method in the differential diagnostics of early endometrial changes.

The authors have performed in 30 cases ultrasonic examination of the endometrium followed by vacuum aspiration with TIS-U-TRAP device (Milex Prod. Inc., Chicago) with equipped a transvaginal head, to obtain samples for histological examination. In 8 of the 30 cases endometrial hyperplasia, while in 2 cases endometrial adenocarcinoma was verified. The authors suggest that transvaginal ultrasonic examination together with vacuum aspiration is suitable for oncological screening of the endometrium.

Adenocarcinoma↗
PubMed1989

[Transvaginal ultrasonic studies].

The authors report their results obtained by the use of a new sonographic technique, transvaginal sonography. Transvaginal sonograms were compared with conventional transabdominal scans in 40 patients. In 35 per cent of cases the quality of the transvaginal image was found to be superior compared to that of the transabdominal image. The authors summarize the indications of transvaginal sonography and its advantages in comparison with conventional method. They recommend this new technique for the examination of pelvis in women in any ultrasound laboratories.

Female↗
PubMed1989

Cytochemical detection of nickel in endometrial carcinoma during progestogen treatment.

During progestogen treatment, nickel ions were detected in the human endometrial tissue of patients with endometrial carcinoma by the dimethyloxime cytochemical method. In this paper, the mechanism of action of nickel is dealt with and, because nickel ions have earlier not be detected in human endometrial carcinomatous tissues, the question arises as a result of what kind of cell biological processes, nickel ions appear in the cells of endometrial carcinoma. It is still to be answered whether the progestogen treatment applied can be correlated with the appearance of the trace element in the carcinomatous cell.

Adenocarcinoma↗
PubMed1989

New possibilities of recognizing early endometrial changes.

Ultrasonographic examinations completed by electron microscopic study were made with transvaginal head in 15 cases. According to the authors, the combined use of these two methods can improve the chances of detecting and recognizing early hyperplasia, preblastoses as well as endometrial tumours.

Adult↗
PubMed1989

Clinicopathological problems of the local tissue effect of copper-containing IUDs. II. Electron-microscopic study of the endometrial scraping.

For assessment of the tissue effect of copper-containing IUDs routine electron microscopic study was made of the endometrial scrapings. It was established that there was evidence of severe, degenerative changes not only on the IUD but also in the endometrial cells and, occasionally, also in the muscle layer of the uterus. These were characterized by pyknosis of the endometrial cells and alterations of the intracellular components. In this material of the study of 22 endometrial specimens obtained from beside IUDs, relatively few microtubuli were found in the endometrial cells. The changes seemed to be too severe to be ascribed to a sterile inflammation. The sporadic changes in the endothelial cells were found to be non-specific.

Actin Cytoskeleton↗
PubMed1989

Clinicopathological problems of the local tissue effect of IUDs containing copper. III. Cytochemical study of the endometrial scrapings.

The clinicopathological problems of the tissue effect of copper-containing IUDs are discussed. In the third part of their series, authors present the cytochemical analysis of the endometrial scrapings. For the investigations, dithizone, salicylaldoxime, rubeanic acid as well as dimethylglyoxime were used. The reaction precipitate, the copper dithizone complex, could be visualized partly intracellularly and intramitochondrially and partly interstitially. The technical problems of copper demonstration are also dealt with.

Copper↗
PubMed1988

Cytochemical examinations of Ca, cytochrome oxidase and succinate dehydrogenase enzymes in endometrium carcinomatous tissue after high dose progestogen treatment.

Authors investigated the effect of high dose progestogen in endometrium carcinomatous tissue on the distribution of calcium depots, as well as on the chemically detectable activity of cytochrome oxidase and succinate dehydrogenase. By means of electron microscopy no characteristic destructive effect could unequivocally be demonstrated; cytochemical examinations showed a very significant activity of cytochrome oxidase, and in the activity of succinate dehydrogenase a considerable decrease was observed. They found distributional alterations in plasma membranes, in mitochondria and in the ground cytoplasm. Changes between Ca depots are thought to have an effect on tumour cells also in a protective way, and can be regarded as compensatory phenomena.

Antineoplastic Agents↗
PubMed1988

Nickel- and cadmium-induced fetal myocardial changes in the mouse: the hazards of cigarette smoke in pregnancy.

The prolonged effect of nickel chloride and cadmium chloride on the rat fetal myocardium was studied experimentally administered to the pregnant mother through a gastric tube in doses of 12.5 mg/b. wt. It could be demonstrated that, due to nickel administration, changes simulating cardiomyopathy and severe mitochondrial lesions developed and the number of collagenous fibres and glycogen granules accumulated, while as a result of cadmium chloride administration, changes were apparent mainly in the endothelial cells, but with simultaneous mitochondrial impairments, too. Nickel and cadmium are contained by cigarette smoke. Based on experimental studies, authors propose new arguments on the damaging effect of smoking of pregnant women.

Animals↗
PubMed1988

The morphological study of copper chloride-induced lesions in isolated heart.

Rat hearts isolated according to Langendorff were perfused with Krebs-Henseleit medium containing 10(-7)-10(-4) mol/l CuCl2 solution. Using morphological studies combined with electron microscopic and cytochemical techniques, it was established that, by contrast to other tracer elements, severe lesions initially affect the capillary endothelium then the fibre system, being first characterized by edema of the capillary wall, accumulated pinocytotic vesicles and later by hyperconcentration necrosis. Using a concentration of 10(-4) mol/l, oxygen-paradox- or calcium-paradox-type impairments develop.

Animals↗