[Erythrocyte isolation from blood with cotton].
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Centrifugation↗
Biomedical subjects
K Pelz
Publications and source records attributed to K Pelz.
Neurotropic and psychotropic agents. 8. 10-(4-Methylpiperazion)-10,11-dihydrodibenzo(b,f)thiepine and analogs; a new group of potent neuroleptics. (Preliminary communication).
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In Vitro Techniques↗
[Clinical studies of the efficacy and tolerance of cefotaxime, ceftizoxime and ceftriaxone in patients with complicated urinary tract infections].
An open randomised clinical study was performed in three groups of 20 patients each with well-defined complicated urinary tract infections to compare the efficacy and tolerance of cefotaxime (1-2 g b.i.d.), ceftizoxime (2 g b.i.d.) and ceftriaxone (2 g u.i.d.). Treatment was administered intravenously over seven days. 63% of the patients were free of infection three to five days after the treatment. There was no significant difference in the efficacy of the three antibiotics with respect to the elimination rate of the sensitive bacteria. There were differences, however, with respect to the development of resistance and the occurrence of superinfections during therapy. No resistance developed during therapy in the ceftizoxime group. Resistance developed twice in the cefotaxime group and three times in the ceftriaxone group. Superinfections with resistant bacteria occurred significantly more frequently in the cefotaxime group (n = 8) than in the ceftriaxone group (n = 2). Six superinfections were observed in the ceftizoxime group. These differences, which could not be explained by the presence of complicating clinical factors, were considered to be due to the pharmacokinetic properties of the substances.
Adult↗
[Clinical study of the effectiveness and tolerance of norfloxacin in the therapy of complicated urinary tract infections and in long-term prevention of recurrent urinary tract infections].
The efficacy and tolerance of norfloxacin in the treatment of complicated urinary tract infections and in low dose long-term prophylaxis over six months for recurrent UTI were investigated in 60 and 27 patients, respectively. In the prophylaxis group, compliance with medication was controlled weekly using Mecur BT. Five to nine days after treatment, the urine was sterile in 50 out of the 60 patients treated (83.3%); relapse occurred in six patients and was associated with development of resistance in two. Four patients suffered re-infection within the study period. Failure of treatment was closely related to persisting complicating factors in the urinary tract. The overall tolerance of norfloxacin was satisfactory. However, there was one severe allergic reaction. During the total 391 weeks of low dose long-term prophylaxis given to 27 patients, only one break-through infection occurred. Yet compliance studies proved that antimicrobial activity was present in the urines of less than 50% of the patients. During prophylaxis, the rate of infection was reduced from three to four to 0.13 to 0.05 infections/patient/year. There was no development of resistance in the isolates from these patients. Only two adverse reactions were observed.
Administration, Oral↗
Gas chromatographic detection of Mycobacterium tuberculosis complex in pure cultures from respiratory specimens.
It is important to identify mycobacteria to the species level in order to establish their clinical significance and to take the appropriate therapeutical decision. Biochemical tests on primary cultures take time (3-6 weeks) until the report of results; that's why more rapid techniques are needed. We have used gas chromatography with flame-ionisation detection (GC-FID) as an alternative identification method for 53 mycobacterial strains isolated from respiratory specimens. We have extracted fatty acids from whole mycobacterial cells, then derivatized them into methylesters, detectable by GC-FID. All the strains were identified as M. tuberculosis complex (MTC), using the Microbial Identification System (MIS) software. The specificity of the identification by GC-FID of MTC is 100%. In conclusion, pulmonary mycobacteriosis are dominated by MTC; GC-FID is a rapid and accurate method for the identification of MTC.
Chromatography, Gas↗