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Biomedical subjects

K Riedl

Publications and source records attributed to K Riedl.

11 recordsLinked to original sources
PubMed1976

Antibiotic prophylaxis in allo-arthroplastic hip joint surgery. Concentration assays in the wound exudate after parenteral administration of gentamicin.

The indecation and the efficacy of antibiotic prophylaxis in endoprosthetic operations are discussed with reference to prospective studies. After parenteral administration of 80 mg gentamicin the antibiotic concentrations in the serum and in the wound exudate were studied for 2 to 6 hrs after administration. During this observation period the gentamicin concentrations in the wound exudate were about equal to those in the serum. A comparison of the concentrations after parenteral and after local administration of gentamicin showed much higher concentrations in the wound exudate when gentamicin was administered with the bone cement.

Administration, Topical↗
PubMed1976

Studies on pleuromutilin and some of its derivatives.

A number of derivatives of pleuromutilin (I) and of its degradation product, mutilin (II1, was prepared. The new monotosylation product of pleuromutilin (IIIc) served as the key substance for modification of the glycolic acid side chain. From the pleuromutilin monosuccinate (IIIk) water-soluble salts were obtained, among them the crystallized diethylaminoethanol salt that was investigated more closely. Some of the pleuromutilin derivatives showed antimicrobial activity.

Anti-Bacterial Agents↗