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Biomedical subjects

K Roth

Publications and source records attributed to K Roth.

At least 37 records · Page 2Linked to original sources
PubMed1978

Adrenergic control of motor activity: effects of PNMT inhibition upon open field behavior in the rat.

Two inhibitors of brain PNMT were given to rats in doses which caused equivalent reductions in enzyme activity. Each drug produced similar and dose-related decreases in ambulation, rearing and defecation during open field behavioral testing. Central adrenergic (epinephrine containing) system may be necessary for normal open field behavior. This may reflect an interaction with other monoamines, particularly dopamine.

Animals↗
PubMed1976

Beta-methylcrotonic aciduria associated with lactic acidosis.

A patient is described in whom lactic acidosis of very severe degree was found to coincide with the presence of beta-methylcrotonic acid and rho-hydroxyphenyllactic acid in urine in large amounts, while beta-hydroxyisovaleric acid was found to be a relatively minor excretion product. Beta-methylcrotonic acid is demonstrated, for the first time, to be present in blood and CSF. These findings are discussed in relation to the patients previously reported to have beta-methylcrotonylglycinuria and raise the possibility that our patient's organic aciduria may be secondary to acquired disease rather than to an inborn error of metabolism.

Amino Acids↗
PubMedDate not supplied

Metabolism of nafronyl in man.

The metabolism of nafronyl (I) has been studied in man. In addition to small amounts of the parent compound, three acidic metabolites were extracted from urine. The chemical structures of all metabolites were determined by using mass spectrometry and [1H]-NMR spectroscopy as tetrahydro-beta-(1-nephthalenylmethyl)-2-furanpropionic acid (II) and two stereoisomers of 3-(1-naphthalenylmethyl)-tetrahydrofuran-2-one-5-propionic acid (III, IV). The biodegradation products III and IV are formed after oxidation of the tetrahydrofuran system in II, hydrolytic ring opening of the gamma-butyrolacton and a subsequent formation of a gamma-butyrolacton ring with the second carboxyl group. The three metabolites represent the major fraction of unconjugated products in the urine of man after administration of nafronyl.

Adult↗