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Biomedical subjects

K S Chertkov

Publications and source records attributed to K S Chertkov.

At least 19 recordsLinked to original sources
PubMed1994

Space radiobiology program in Russia.

The space radiobiology program in Russia is aimed at obtaining fundamental data for developing radiation safety criteria. These criteria are necessary for long-term space missions. This program includes : -substantiation of radiation hazard estimation principles based on the radiation risk conception, -investigation of the radiation affection regularities under the combined influence of the spaceflight factors, -experimental investigation of the HZE-particle delayed effects and acute somatic effects induced by protons and electrons, -individual radiosensitivity investigation, -mathematic modeling of radiobiological effects , -radiobiological basis of control and forecast of radiation influence in space, -development of methods and means of an organism's radioresistance increase.

Aerospace Medicine↗
PubMed1986

Protection of monkeys against prolonged gamma-irradiation.

The radioprotective effect of the Bulgarian drug Adeturone was tested on prolonged irradiated monkeys. The animals were gamma-irradiated (137Cs) in a dose of 8.3 Gy (exposure rate 3.95 X 10(-3) mA.kg-1; (0.92 R.min-1]. Adeturone, given by i.v. injection at a dose of 100 mg.kg-1 body weight according to a pre- and postradiation scheme will afford protection to monkeys by ensuring 50% survival and mitigating the severity of some symptoms of radiation disease. A similar effect was obtained with ATP-administration by two i.m. injections of 37 mg.kg-1 body weight. The survival in control group was only 5% (LD95/45).

Adenosine Triphosphate↗
PubMed1982

[Changes in hemostatic system indices during hemosorption in healthy dogs].

Experiments on normal dogs were made to study the effect of hemosorption on some of the characteristics marking down the hemostatic system: the content of platelets and fibrinogen, the times of plasma recalcification and euglobulin lysis, the prothrombin time, the ethanol and protamine sulfate tests, and fibrinase activity. Hemosorption produces no abrupt shifts on the part of the blood coagulation system. Additional administration of heparin does not prevent "caking" of the sorbent. The reduction in the number of circulating platelets induced by hemosorption is then replaced by pronounced thrombocytosis.

Animals↗
PubMed1977

[Effect of poly-4-vinylpyridine on the quantity of colony-forming cells in the bone marrow and spleen of mice].

Administration of poly-4-vinylpyridine to mice in the maximal tolerance dose doubled the colony-forming units (CFU) and decreased the cell count by 22% in the bone marrow. The increase of CFU number takes place from 2 to 7 days. The cell count in the bone marrow began to decreased 2 hours after the administration of the polymer and remained below the initial level for 5 days; however it began to return to the normal from the second day, reaching the normal figures by the 7th day. In the spleen the CFU rose 9-fold, with a simultaneous development of splenomegaly on account of increased cell count.

Animals↗
PubMedDate not supplied

[Advances and prospects of a combined therapy of acute radiation injury in experiments].

We present the results of a long-standing experimental development of ways and means for acute radiation sickness treatment that have been authorized for application in medicine and are mostly aimed at large-scale accidental injuries. The paper describes means for early treatment (prodigiosan, desoxynate, typhoid vaccine, proteus vaccine), a myeolopoiesis stimulant (estradiol dipropionate), a detoxication procedure (hemosorption), substitution therapy with bone marrow cells and peripheral blood mononuclears, anti-infectious schemes comprising antibiotics and polyvitamins.

Acute Disease↗
PubMedDate not supplied

[Efficiency of polysaccharide translam for early treatment of acute radiation illness].

Antiradiation therapeutic efficiency of translam (1-->3; 1-->6-beta-D-glucan) produced by enzymatic synthesis out of laminarin, polysaccharide of Laminaria cychorioides, has been studied in four animal species (mice, guinea-pigs, dogs, monkeys). A stable curative effect has been observed following its administration within first 24 h after radiation exposure at doses that cause acute radiation sickness (about LD90). The preparation is nontoxic and has a broad therapeutic range which permits its practical application.

Acute Disease↗
PubMedDate not supplied

[An experimental approach to determining the protective properties of drugs against ionizing radiation in low and sublethal doses].

In experiments with mice, the efficiency of radioprotective agents against acute gamma-irradiation with nonlethal and low doses (0.5-4 Gy) was estimated by nine parameters. The treatment with cystamine, cysteamine and riboxine prior to irradiation (< 2 Gy) did not influence the postirradiation values of the parameters under study. With a dose of up to 4 Gy, the effect of riboxine was noted. The determinations of the number of aberrant mitoses, cellularity and mitotic activity of the bone marrow have proved to be most informative. The data obtained are discussed with due regard for the specific effect of low-level radiation and mechanisms of the protective action of the agents under study.

Animals↗
PubMedDate not supplied

[Characteristics of the dynamics of hematopoietic precursor cells cloned in diffusion chambers and recorded in experiments on mice and dogs irradiated in median lethal doses].

In experiments with mice and dogs irradiated with LD50, it was shown the postirradiation depopulation of haemopoietic polypotent (CFUs) cell-precursors in mouse bone marrow was more pronounced than that of granulocytic and macrophagal cells (CFUdc). The rate of repopulation of CFUs during the first week was higher than that of CFUdc (T1/2 was 2.5 and 8.8 days respectively). In dogs, one could notice a partial change in the colony formation, a prolonged plateau period in the postirradiation CFUdc dynamics, and a coincidence in time with cellularity restoration in the bone marrow and peripheral blood leukocytes. It is suggested that in conditions of heterogeneous incubation in diffuse chambers, the haemopoietic cell-precursors are more mature than in the syngeneic system. The method of CFUdc determination has proved to be ineffective in estimating the onset and intensity of the postirradiation haemopoiesis recovery in dogs. The study of the bone marrow CFUdc population may, however, be used in intact animals to predict the probability of their death after irradiation within the median lethal dose range.

Animals↗
PubMedDate not supplied

[Study of the antiradiation properties of contrykal in experiments on mice].

From experiments in mice exposed to gamma-rays (LD95 and LD91) it is shown that single intraperitoneal administration of contrykal (30-50 units per animal) elicits a slight (20-30%) radioprotective and therapeutic effect. An insignificant therapeutic effect is also registered after repeated injections of the drug at the height of radiation sickness (on the 5th-20th days).

Animals↗