[Effect of "time factor" of irradiation on the processes of radiation injuries and restoration of hematopoiesis in mice].
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Biomedical subjects
Publications and source records attributed to K S Chertkov.
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The radioprotective effect of ATP and adenosine was investigated on CBA and C57Bl mice hybrids F1 irradiated with 9 GeV protons. The prophylactic treatment of the animals with ATP at a dose of 350-700 mg/kg increased their survival to 63-80% for LD78-83/30 (7.5-8.0 Gy) and to 40% for LD96/30 (8.5 Gy). The administration of adenosine at a dose of 340 mg/kg, equimolar to 700 mg/kg ATP, increased their survival to 93-100% and 73%, respectively. It was found that ATP produced a favorable effect on the hemopoiesis of irradiated mice.
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Following radiation damage from LD50-LD97, changes in blood, immune and endocrine parameters were revealed and followed up in dogs at the time of late effects development, 3-18 months after exposure. The changes result from post-radiation immunodeficiency and resemble those observed in residents of radioactive contaminated areas or in men participated in Chernobyl accident amelioration.
In experiments with mice radioprotective effect of N-methylascorbigen was revealed. DRF calculated from survival data was 1.16 when N-methylascorbigen (100 mg/kg) was administered i/p 24 h before irradiation.