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Biomedical subjects

K Schirmer

Publications and source records attributed to K Schirmer.

At least 19 recordsLinked to original sources
PubMed1989

[Idiopathic and diuretic-induced edema].

In female patients with intermitting or permanent inclination to oedemas and intake of diuretics after exclusion of cardiac, renal, venous and lymphogenic causes should be thought of the clinical picture of the idiopathic and diuretic-induced oedema, respectively. Pathophysiologically, the two forms underlie an activation of the renin-angiotensin-aldosterone system with subsequent retention of water and common salt. In these cases the intake of diuretics is not indicated and may lead to the chronification of the oedemas. Therefore the physician is confronted with the responsible task to finish the permanent intake of diuretics by adequate explanation of the pathophysiological and pharmacological connections and to care for the frequently neurotic female patients in this difficult time. For a short time a treatment with aldosterone antagonists can be recommended and first therapeutic experiments with the application of ACE-inhibitors were successful. A special diet poor in common salt is not necessary and in the individual case a psychotherapeutic treatment of the female patients should be carried out.

Adult↗
PubMed1987

[IgA nephropathy].

Among the chronic glomerulonephritides the IgA-nephropathy is one of the most frequent forms. On account of the possibility of the transition into the terminal renal insufficiency new ways for the therapeutic influence on this disease must be found. In the hitherto used therapy methods above all corticosteroids, cytostatic drugs, inhibitors of thrombocyte aggregation and antiphlogistic drugs were applied. According to the recent investigations from the application of eicosapentaenic acid and the use of plasmapheresis possibilities result to favourably influence the course of the disease and thus to prevent a progression of this disease. By the administration of diphenylhydantoin the IgA-level could, indeed, be lowered, but an influence on the course of the disease could not be proved.

Glomerulonephritis, IGA↗
PubMed1981

[Immunologic aspects of glomerular kidney diseases].

The experiment is made to describe the present knowledge of immune pathogenesis of the glomerulonephritis and the therapeutic account resulting from this. On principle it is to be differentiated between basal membrane-antibody-glomerulonephritis, as it is to be found above all in Goodpastures syndrome, and the essentially more frequent immune complex nephritides. However, immune complexes lead to pathological effects only then, when the capacity of phagocytosis has been transgressed or a qualitative or quantitative reduction of the immune response at humoral and/or cellular level is existing. Therapeutic points of influence result from the removal of the antigen, the influence on the production of antibodies (immunosuppression, immunostimulation, induction of the immunotolerance) and the influence on the effector mechanisms by antiphlogistics.

Anti-Glomerular Basement Membrane Disease↗
PubMed1981

[Kidney involvement in "mixed connective tissue disease" (Sharp syndrome)].

The case in question of the Sharp-syndrome is a mixed collagenosis with symptoms of sclerodermia, Erythematodes visceralis, dermatomyositis and rheumatoid arthritis. Apart from the clinical symptomatology the immunological profile is decisive for the ascertainment of the diagnosis. With the help of 3 descriptions of cases is referred to a frequent participation of the kidneys, particularly histologically and immune-histologically. In contrast to the hitherto existing publications also in missing pathological findings of the urine a renal biopsy should be aspired to, since important therapeutic and prognostic considerations are dependent on this.

Adult↗
PubMed1979

[Diagnostic value of the detection of antibody-bound bacteria in the urine].

By means of the immunofluorescence technique 107 patients with chronic pyelonephritis and 43 patients with an infection of the lower urinary tract were examined for the presence of antibody-containing bacteria in the urine. Here in 84 out of 107 patients (78.5%) with a chronic pyelonephritis the positive proof could be made, whereas in 39 out of 43 patients (90.6%) with an infection of the lower urinary tract no antibody-containing bacteria were found. The test may be recommended as a relatively simple, riskless and evident method for the diagnostics of pyelonephritis.

Antibodies, Bacterial↗
PubMed1979

[Vitrectomy under optical observation (author's transl)].

Slit lamp biomicroscopy without contact lens is achieved by upright Gullstrand fundus microscopy. The controlled angulation of the slit beam makes it possible to measure the position of objects in the vitreous cavity by correction of object and image points. This form of stereotaxis is used for guiding the laser beam in the fundus.

Fundus Oculi↗
PubMed1975

[Problems of hepatitis in dialysis patients, technical personnel and their relatives].

In a centre for dialytic treatment of the district Karl-Marx-Stadt during 16 months patients and staff underwent a continuous clinico-epidemiological observation. By means of determinations of serum enzymes and Au-antigen-investigation regularly carried out in these cases the special risk of hepatitis could be confirmed. Hygienic-antiepidemic and organization measures are discussed and recommendations are given concerning the prophylactically more aimed course. Further investigations are necessary in as far as certain basic diseases (i.g., renal insufficiency) have an influence on the Au-antigen-persistence by impairment of the immune system and which epidemiological effects may result from this.

Female↗