[Dynamic pedo-barography as a diagnostic tool in the determination of degree and localization of metatarsalgia].
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Diagnosis, Computer-Assisted↗
Biomedical subjects
K Tóth
Publications and source records attributed to K Tóth.
[Bilateral traumatic posterior dislocation of the shoulder].
Authors describe an extremely rare case of simultaneous bilateral posterior dislocation of the shoulder. The referring international literature and that of this country is surveyed. In the latter no paper, describing bilateral posterior dislocation of the shoulder was published. They have found this case, because of its rarity, worthy of publication.
Humans↗
[Results of percutaneous wiring, using Kirschner wires, in the management of distal radius fractures susceptible to re-dislocation].
During 6 years (1980-1985) 1876 patients with fractures of the distal end of the radius were treated in the County Hospital-Polyclinic Unit "Kaposi Mór". In this paper 302 cases, reduced and pinned with K-wire are discussed. 247 could be controlled 5-10 years after the injury. On the basis of the results in unstable fractures of the distal radial end, susceptibles for redislocation closed pinning with K-wire, following correct reduction is suggested.
Bone Wires↗
[Results of closed pinning of supracondylar humerus fractures using Kirschner wires].
In the Department of Traumatology of the County Hospital "Kaposi Mór" 150 children with supracondylar fracture of humerus were treated during 10 years (1980-1989). 119 cases reduced and pinned with percutaneous Kirschner wire are dealt with. 98 cases could be controlled 2-10 years after the accident. The importance of urgent treatment is stressed. The urgent reduction and the closed pinning with Kirschner wire are thought to be an efficient prophylaxis against Volkmann's ischaemic contracture and varus deformity, caused by secondary movements.
Age Factors↗
Hippocampal pyramidal cells excite inhibitory neurons through a single release site.
Morphologically a synapse consists of a presynaptic release site containing vesicles, a postsynaptic element with membrane specialization, and a synaptic cleft between them. The number of release sites shapes the properties of synaptic transmission between neurons. Although excitatory interactions between cortical neurons have been examined, the number of release sites remains unknown. We have now recorded excitatory postsynaptic potentials evoked by single pyramidal cells in hippocampal interneurons and visualized both cells using biocytin injections. Light and electron microscopy showed that excitatory postsynaptic potentials were mediated by a single synapse. We also reconstructed the entire axon arborization of single pyramidal cells, filled in vivo, in sections counterstained for parvalbumin, which selectively marks basket and axo-axonic cells. Single synaptic contacts between pyramidal cells and parvalbumin-containing neurons were dominant (> 80%), providing evidence for high convergence and divergence in hippocampal networks.
Animals↗
Postsynaptic targets of GABAergic hippocampal neurons in the medial septum-diagonal band of broca complex.
The termination pattern of hippocamposeptal nonpyramidal cells was investigated by injecting Phaseolus vulgaris leucoagglutinin (PHAL) into stratum oriens of the CA1 region. Electron microscopic analysis showed that the majority of the anterogradely labeled boutons formed symmetric synapses with dendrites and occasionally with cell bodies located in the medial septum-diagonal band of Broca complex. We have demonstrated with postembedding GABA immunocytochemistry that the majority of PHAL-labeled axon terminals were GABAergic. The neurochemical character of the postsynaptic target cells was also investigated using immunocytochemical double staining. Our data showed that the majority of the labeled hippocamposeptal axons innervated parvalbumin-immunoreactive cells representing GABAergic projection neurons, and a smaller number of contacts were found on ChAT-positive neurons. Septohippocampal neurons identified by retrograde HRP transport were also shown to reactive direct hippocamposeptal input. According to recent results, the lateral septum is unlikely to relay the hippocampal feedback to the medial septum; therefore, the direct hippocampal projection to the medial septum, arising from GABAergic nonpyramidal cells, seems to be the only feedback pathway to the area containing septohippocampal neurons. A novel circuit diagram, based on our recent morphological-immunocytochemical findings, is shown for the synaptic organization of the septo-hippocampo-septal loop. We suggest that the GABAergic hippocamposeptal feedback controls the activity of septal (mostly GABAergic) projection neurons as a function of hippocampal synchrony. The newly discovered reciprocal interactions may give a better insight into septohippocampal physiology.
Afferent Pathways↗
[Experience with the surgical management of fractures of the tibial head].
In the Department of Traumatology of the "Kaposi Mór" County Hospital 213 patients with the fracture of the proximal end of the tibia were treated during 10 years (1980 + 89). 165 operated cases are analysed, 120 of them could be controlled 1.5-9 years after the operation. The importance of the reconstruction of the articular surfaces is stressed and attention is called to the increased possibility of infection in these operations.
Adolescent↗
Influence of blood viscosity on circulatory parameters determined by first-pass radionuclide angiocardiography in cor pulmonale.
First-pass radionuclide angiocardiography (FPRNA) with 99mTc-albumin was performed in 19 patients with cor pulmonale. Pulmonary circulation time (PCT), mean transit time (MTT), pulmonary stagnation index (PSI) were calculated from the time-activity curves for the estimation of cardiopulmonary circulation. Whole blood viscosity (WBV), plasma viscosity (PV) and hematocrit (HTC) were also measured on the same day. Significant prolongation of all parameters was observed (WBW: 5.04 +/- 1.19 mPas; PV: 1.36 +/- 0.17 mPas; HTC: 47.6 +/- 2.37%; PCT: 7.10 +/- 2.15 s; MTT: 9.33 +/- 4.11 s; PSI: 1.30 +/- 0.37) in patients with cor pulmonale. Significant positive correlations were found between PCT and WBV (r = 0.552; 0.001 < P < 0.01), MTT and WBV (r = 0.34; P < 0.05), furthermore between PCT and HTC (r = 0.356; P < 0.05). The results suggest that hemorheological parameters may influence the results of FPRNA, therefore, they should be determined in addition to the radionuclide study.
Adult↗
[Duplex ultrasound scanning of the carotid arteries in patients with obliterative diseases of the lower extremities].
The authors practiced carotis duplex scanning examinations on 60 patients having lower limb artery disease. The patients were grouped according to, having cervical bruit or not. In the first group 100% had stenosis while in the second group had only 13.3%. Furthermore the stenosis--plack were analysed according to the severity of the lower limb artery disease. The severity of stenosis can be found in group "A" (bruit exists) and group "B" (no bruit) accordingly to the Fontaine stages. Stenosis higher then 50% was found in group "A" 3 in Fontaine stage II, and 10 in Fontaine stage III. While in group "B" there were no stenosis in Fontaine stage II, and 4 in Fontaine stage III. Out of thet not exceeded 3, 50%, and 1 was subtotal. Likewise, difference can be found of the presence of placks partly in the two groups, partly in the point of view of the stages of Fontaine. There are in group "A" 23 cases with 48 placks, in group "B" 14 cases with 23 placks. Among the patients of group "A" in 10 cases with were in Fontaine II, and 13 in Fontaine III stage. In group "B" 5 were in Fontaine II, and 9 in Fontaine III stage. Authors are calling the attention, that according to their own data, and the sensitivity of duplex scanning this is the most proper examination for recognising the carotid artery sclerosis which is associated with lower limb artery disease.
Carotid Artery Thrombosis↗
Order- alpha radiative corrections for semileptonic decays of polarized baryons.
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Journal Article↗
Growth of human renal cortical tissue on collagen gel.
A model system for 3-dimensional "native-state" culture of tissues on collagen gels (Proc. Natl. Acad. Sci. USA 86:2013-2017; 1989) has been applied in this study to histologically normal human renal cortical tissue from 11 patients undergoing nephrectomy for renal cell carcinoma elsewhere in the kidney. Microbial contamination occurred in 12/90 cultures, the rest (78) were studied by visual inspection, histology, immunohistochemical analysis for pankeratin (epithelial cell origin), vimentin (mesenchymal cell origin), and p-glycoprotein (associated with proximal tubules), transmission electron microscopy (EM), incorporation of tritiated thymidine (3HTdR). In the first 10 days, explants showed 3HTdR-labeled cells in tubule structures. The surrounding gel was invaded by cells forming tubule structures, sometimes with basement membrane. Some of these cells showed labeling by 3HTdR and immunostaining positive for pankeratin and p-glycoprotein. EM showed well-polarized epithelial cells in tubule structures with tight junctions, interdigitating lateral processes, and microvilli characteristic of proximal and distal convoluted tubules. 3HTdR-labeled cells in tubule structures were observed even 2 mo. after Passage 1, 6 mo. after the initial explantation. Tubule growth was most active and fibroblast proliferation was negligible from 2 to 4 wk postexplantation. The proliferation of tubulelike cells and formation of tubulelike structures in this system represents an opportunity to study human renal cortical tissue in vitro, under conditions more closely resembling in vivo circumstances than are present in other in vitro systems suitable for long-term study. This model has potential use for in vitro toxicology studies and studies of renal physiology.
ATP Binding Cassette Transporter, Subfamily B, Mem↗
Calbindin D28k-containing nonpyramidal cells in the rat hippocampus: their immunoreactivity for GABA and projection to the medial septum.
Calbindin D28k-containing non-pyramidal cells were found in all layers and subfields of the hippocampus, with the highest frequency in stratum radiatum of the CA1-CA3 subfields. A large number of these neurons had a vertically oriented dendritic tree, often restricted to to stratum radiatum. In stratum oriens and near to the border of strata radiatum and lacunosum moleculare cells with horizontally running dendrites were also found. Multipolar cells were most common in stratum radiatum of the CA3 region. The GABAergic nature of the calbindin D28k-containing non-pyramidal cells was studied using the "mirror" technique. Adjacent thick sections were immunostained for calbindin D28k and GABA, and halved neurons were identified on the common surfaces. The majority of calbindin D28k-containing non-pyramidal cells were shown to be GABAergic. The GABA-negative calbindin cells were found in relatively large numbers in stratum oriens of the CA1-CA3 region, and occasionally in strata radiatum and pyramidale of CA2, and in stratum radiatum of the CA3c region near to the border of the dentate hilus. However, even in these cells a weak immunostaining, only slightly but consistently above background level, was always observed. Earlier studies have demonstrated that the somata of GABAergic neurons with distant projections may contain a level of GABA that is below the detection threshold of immunocytochemistry. Here we provide direct evidence that the calbindin-containing non-pyramidal cells were among those projecting to the medial septum. Following horseradish peroxidase injections into the medial septum 80% of the retrogradely labelled non-pyramidal cells were found to be immunoreactive for calbindin D28k, and 20% contained neuropeptide Y. These results suggest that the calbindin D28k-containing and apparently GABA-immunonegative non-pyramidal cells in stratum oriens of the CA1-CA3 regions may also be GABAergic, but have a distant projection, that is, to the medial septum.
Animals↗
Phage nucleoprotein-psoralen interaction: quantitative characterization of dark and photoreactions.
The irradiation of the phage T7 system containing psoralen as photosensitizer causes many processes, each of them leading to phage inactivation. These processes include the UV-induced photoreactions in the phage nucleic acid, and photoreactions in the nucleic acid sensitized by either psoralen or psoralen photobreakdown products. In addition the intercalation of the psoralen molecule itself in the phage nucleic acid as well as the psoralen photobreakdown products cause phage inactivation. Under appropriate experimental conditions these reactions can be studied and characterized separately. The quantitative characteristics (e.g. inactivation cross-section, action spectra and index for dark genotoxicity) are demonstrated for different linear and angular psoralens. Some theoretical and practical consequences of the results obtained are discussed.
Darkness↗
Oxygen free radicals, lipid metabolism, and whole blood and plasma viscosity in the prevention and treatment of human cardiovascular diseases.
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Animals↗
[On the article "Dental status of young recruits in the light of a 15-year experience", by Vass and Harsányi].
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Adolescent↗
[Surgical treatment of hallux valgus by peg osteotomy].
Authors describe a method of therapy of hallux valgus not yet published in this country. Its advantage is that as a consequence of the shortening of the proximal phalanx the tension of the soft tissues is decreased and as a final result the movement occurs between the original cartilaginous surfaces.
Bone Nails↗
Comparison of an immunoperoxidase "sandwich" staining method and western blot detection of P-glycoprotein in human cell lines and sarcomas.
The applicability of a multilayer immunoperoxidase "sandwich" method (IpS) developed by Chan14 for the amplified detection of P-glycoprotein (Pgp) was investigated. The authors examined 15 formalin-fixed cell lines, as well as formalin-fixed, paraffin-embedded sections from single biopsies of 46 sarcomas. The cell lines included sensitive and multidrug resistant sublines (KB, A2780, MCF-7, HeLa) with various relative degrees of resistance to doxorubicin (Dox). The sarcoma biopsy specimens were selected on the basis of the results obtained in Western blot (WB) detection of Pgp (22 positive and 24 negative by WB) using C219 and C494 monoclonal antibodies to Pgp. The IpS method employed C219. The least resistant cell line in which Pgp could be detected by IpS was fivefold resistant to doxorubicin, whereas Pgp was detected by WB in cells greater than twofold resistant. Cell lines having greater than fivefold resistance to Dox were positive by both IpS and WB analyses. The less resistant cell lines contained more nonreactive cells whereas the highly resistant cell lines showed more homogeneous strong membrane reactions. Among the six cell lines determined to be Pgp negative by WB analysis, no false positive immunostaining by IpS existed. One of 22 WB positive and 7 of 24 WB-negative sarcoma biopsy specimens were positive by IpS methods. Reaction varied and was always focal (a minimum of 3-5 cells, ranging up to 3-4 high power fields) indicating pronounced heterogeneous distribution of Pgp. Thus, WB can detect low average (overall) levels of Pgp in tumor samples but such low concentrations of PgP at the single cell are not detectable by IpS methods. However, IpS can discern among many Pgp-negative cells small subpopulations of immunoreactive cells, which are not detected by WB analysis due to Pgp dilution by the membrane protein of numerous Pgp negative cells. IpS and WB used together as complementary methods can provide more complete information about Pgp distribution and content, particularly in the case of heterogeneous human tumors. The IpS method is more suitable for less drastically treated (not embedded) cell line specimens than for paraffin-embedded (routine) sections. Some modification of the present IpS protocol seems necessary to increase its sensitivity and reduce the disparity with WB results.
ATP Binding Cassette Transporter, Subfamily B, Mem↗
[Pharmacokinetics and metabolism of selegiline].
As it has been shown is animal experiments, selegiline administered orally is absorbed rapidly. The compound penetrates the blood-brain barrier and the concentration of selegiline and/or its metabolites is high in the brain. Selegiline is eliminated primarily by renal excretion (73%) and 14% of the dose is eliminated with faeces. The main metabolic pathway is N-dealkylation. N-demethyl-selegiline, amphetamine and methamphetamine are the main metabolites. p-Hydroxylated derivatives of amphetamine and methamphetamine could also be identified in rat urine. (-)-Selegiline gives rise to (-) metabolites and does not undergo racemization. Selegiline is bound to macromolecules extensively. The metabolites have lower affinity to plasma proteins than the parent drug do. Selegiline and its metabolites do not accumulate in the organism not even during prolonged administration.
Animals↗